{"id":"https://openalex.org/W2104282850","doi":"https://doi.org/10.1109/icsmc.2009.5345970","title":"Progress away from evidence based medicine to discovery of dynamic principles of disease and its treatment","display_name":"Progress away from evidence based medicine to discovery of dynamic principles of disease and its treatment","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2104282850","doi":"https://doi.org/10.1109/icsmc.2009.5345970","mag":"2104282850"},"language":"en","primary_location":{"id":"doi:10.1109/icsmc.2009.5345970","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsmc.2009.5345970","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Conference on Systems, Man and Cybernetics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016260778","display_name":"Cathy M. Helgason","orcid":null},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cathy M Helgason","raw_affiliation_strings":["Department of Neurology, University of Illinois, Chicago, Chicago, IL, USA","Department of Neurology University of Illinois at Chicago Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Illinois, Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Neurology University of Illinois at Chicago Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112132660","display_name":"Thomas H. Jobe","orcid":null},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas H Jobe","raw_affiliation_strings":["Department of Psychiatry, University of Illinois, Chicago, Chicago, IL, USA","Department of Psychiatry University of Illinois at Chicago Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Illinois, Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Psychiatry University of Illinois at Chicago Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11814469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"1113","last_page":"1115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12805","display_name":"Cognitive Science and Mapping","score":0.4869999885559082,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12805","display_name":"Cognitive Science and Mapping","score":0.4869999885559082,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10820","display_name":"Fuzzy Logic and Control Systems","score":0.4722000062465668,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statistic","display_name":"Statistic","score":0.6633152365684509},{"id":"https://openalex.org/keywords/observer","display_name":"Observer (physics)","score":0.6497424840927124},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6272852420806885},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.571598470211029},{"id":"https://openalex.org/keywords/fuzzy-logic","display_name":"Fuzzy logic","score":0.5661581754684448},{"id":"https://openalex.org/keywords/object","display_name":"Object (grammar)","score":0.46989890933036804},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.46411946415901184},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.45130643248558044},{"id":"https://openalex.org/keywords/isolation","display_name":"Isolation (microbiology)","score":0.43698006868362427},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3969780504703522},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35737478733062744},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35360804200172424},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.3264186382293701},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.270618200302124},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2381976842880249}],"concepts":[{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.6633152365684509},{"id":"https://openalex.org/C2780704645","wikidata":"https://www.wikidata.org/wiki/Q9251458","display_name":"Observer (physics)","level":2,"score":0.6497424840927124},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6272852420806885},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.571598470211029},{"id":"https://openalex.org/C58166","wikidata":"https://www.wikidata.org/wiki/Q224821","display_name":"Fuzzy logic","level":2,"score":0.5661581754684448},{"id":"https://openalex.org/C2781238097","wikidata":"https://www.wikidata.org/wiki/Q175026","display_name":"Object (grammar)","level":2,"score":0.46989890933036804},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.46411946415901184},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.45130643248558044},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.43698006868362427},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3969780504703522},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35737478733062744},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35360804200172424},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.3264186382293701},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.270618200302124},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2381976842880249},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icsmc.2009.5345970","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsmc.2009.5345970","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Conference on Systems, Man and Cybernetics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2033682401","https://openalex.org/W2051220667","https://openalex.org/W2326811983","https://openalex.org/W2802275444"],"related_works":["https://openalex.org/W2359776416","https://openalex.org/W2353788488","https://openalex.org/W2394779770","https://openalex.org/W3192036299","https://openalex.org/W2361916204","https://openalex.org/W2372011046","https://openalex.org/W2415102733","https://openalex.org/W2387495973","https://openalex.org/W2072346427","https://openalex.org/W2487222174"],"abstract_inverted_index":{"Background:":[0],"Medical":[1],"science":[2],"in":[3,70,121,132],"the":[4,24,30,51,71,77,90,114,126,129],"form":[5],"of":[6,26,62,79,89,92,103,116,140,150],"\u00bfevidence":[7],"based":[8,44],"medicine\u00bf":[9],"demands":[10],"when":[11],"measuring":[12],"any":[13],"object":[14,16],"that":[15,60,101,125],"be":[17,68,145],"isolated":[18],"from":[19,21,23,29,50],"others,":[20,110],"context,":[22,112],"method":[25],"measurement":[27,142],"and":[28,47,55,76,94,113,128],"observer.":[31],"Linear":[32],"non":[33,64],"changing":[34],"relations":[35],"amongst":[36],"variables":[37,102],"are":[38,105],"thus":[39],"defined":[40],"which":[41],"allow":[42],"prediction":[43],"on":[45],"probabilities":[46],"define":[48],"information":[49,61],"resulting":[52],"statistic.":[53],"Method":[54],"Result:":[56],"It":[57],"was":[58],"hypothesized":[59],"a":[63,123,138,146],"statistical":[65],"nature":[66],"could":[67],"sought":[69],"individual":[72],"patient.":[73],"Fuzzy":[74],"logic":[75],"geometry":[78],"fuzzy":[80],"theory":[81],"were":[82],"considered":[83],"as":[84,137],"viable":[85],"methods":[86],"for":[87,148],"discovery":[88],"process":[91],"disease":[93],"response":[95],"to":[96,107],"treatment.":[97],"The":[98],"result":[99],"is":[100,119],"interest":[104],"allowed":[106],"intermingle":[108],"with":[109],"their":[111],"dynamic":[115],"these":[117],"interactions":[118],"measured":[120,130],"such":[122],"way":[124],"measurer":[127],"coexist":[131],"each":[133],"instant.":[134],"Conclusion:":[135],"Isolation":[136],"principle":[139],"scientific":[141],"need":[143],"not":[144],"requirement":[147],"attainment":[149],"medical":[151],"knowledge.":[152]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}