{"id":"https://openalex.org/W2124619546","doi":"https://doi.org/10.1109/icsmc.2007.4413849","title":"Statistical and non linear mapping analysis of patient response to anti platelet therapy","display_name":"Statistical and non linear mapping analysis of patient response to anti platelet therapy","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W2124619546","doi":"https://doi.org/10.1109/icsmc.2007.4413849","mag":"2124619546"},"language":"en","primary_location":{"id":"doi:10.1109/icsmc.2007.4413849","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsmc.2007.4413849","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE International Conference on Systems, Man and Cybernetics","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016260778","display_name":"Cathy M. Helgason","orcid":null},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cathy M. Helgason","raw_affiliation_strings":["Department of Neurology and Rehabilitation, University of Illinois, Chicago, IL, USA","Univ of Illinois, Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Rehabilitation, University of Illinois, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Univ of Illinois, Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048150723","display_name":"Enzo Grossi","orcid":"https://orcid.org/0000-0003-0346-2684"},"institutions":[{"id":"https://openalex.org/I4210132761","display_name":"Bracco (Italy)","ror":"https://ror.org/03wjptj96","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210132761"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enzo Grossi","raw_affiliation_strings":["Pharma Division of Medical Affairs, Bracco SpA, Milan, Italy","Medical Director in the Pharma Division of Medical Affairs, Bracco SpA, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Division of Medical Affairs, Bracco SpA, Milan, Italy","institution_ids":["https://openalex.org/I4210132761"]},{"raw_affiliation_string":"Medical Director in the Pharma Division of Medical Affairs, Bracco SpA, Milano, Italy","institution_ids":["https://openalex.org/I4210132761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044785780","display_name":"Dilip K. Pandey","orcid":"https://orcid.org/0000-0001-7242-3182"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dilip Pandey","raw_affiliation_strings":["Department of Neurology, University of Illinois, Chicago, IL, USA","Department of Neurology, Univeristy of Illinois, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Illinois, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Neurology, Univeristy of Illinois, Chicago, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076130750","display_name":"Aziz Valika","orcid":null},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I16820183","display_name":"Illinois College","ror":"https://ror.org/02ys5x139","country_code":"US","type":"education","lineage":["https://openalex.org/I16820183"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aziz Valika","raw_affiliation_strings":["College of Medicine, University of Illinois, Chicago, IL, USA","University of Illinois, College of Medicine Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, University of Illinois, Chicago, IL, USA","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I16820183","https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois, College of Medicine Chicago, USA","institution_ids":["https://openalex.org/I16820183","https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035758045","display_name":"John Cursio","orcid":"https://orcid.org/0000-0003-2131-1767"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Cursio","raw_affiliation_strings":["Department of Neurology, University of Illinois, Chicago, IL, USA","Department of Neurology, Univeristy of Illinois, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Illinois, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Neurology, Univeristy of Illinois, Chicago, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111804929","display_name":"Larry D. Brace","orcid":null},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry D. Brace","raw_affiliation_strings":["Department of Pathology, University of Illinois, Chicago, IL, USA","Department of Pathology, Univeristy of Illinois, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Illinois, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Pathology, Univeristy of Illinois, Chicago, USA","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22253129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":null,"first_page":"3443","last_page":"3456"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspirin","display_name":"Aspirin","score":0.9101977944374084},{"id":"https://openalex.org/keywords/platelet","display_name":"Platelet","score":0.7888554334640503},{"id":"https://openalex.org/keywords/clopidogrel","display_name":"Clopidogrel","score":0.7295933365821838},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.5207638740539551},{"id":"https://openalex.org/keywords/ex-vivo","display_name":"Ex vivo","score":0.46717390418052673},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.46298137307167053},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3787056803703308},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3088759183883667},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.18948400020599365},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14582592248916626}],"concepts":[{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.9101977944374084},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7888554334640503},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.7295933365821838},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5207638740539551},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.46717390418052673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46298137307167053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3787056803703308},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3088759183883667},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18948400020599365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14582592248916626}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icsmc.2007.4413849","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsmc.2007.4413849","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE International Conference on Systems, Man and Cybernetics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1965680834","https://openalex.org/W1974662349","https://openalex.org/W1985927027","https://openalex.org/W1991655882","https://openalex.org/W2004174739","https://openalex.org/W2017453532","https://openalex.org/W2023692142","https://openalex.org/W2027363545","https://openalex.org/W2033356785","https://openalex.org/W2035619942","https://openalex.org/W2051297375","https://openalex.org/W2055005867","https://openalex.org/W2059064084","https://openalex.org/W2071128523","https://openalex.org/W2077772721","https://openalex.org/W2085890327","https://openalex.org/W2099741732","https://openalex.org/W2100209149","https://openalex.org/W2105649992","https://openalex.org/W2111694200","https://openalex.org/W2112205428","https://openalex.org/W2128630796","https://openalex.org/W2152913912","https://openalex.org/W2414532113","https://openalex.org/W2472572692","https://openalex.org/W4238805501","https://openalex.org/W4255306344"],"related_works":["https://openalex.org/W2279508388","https://openalex.org/W2129507256","https://openalex.org/W2018700837","https://openalex.org/W2370813820","https://openalex.org/W1983076760","https://openalex.org/W2410339737","https://openalex.org/W2086674965","https://openalex.org/W2359827248","https://openalex.org/W2336413601","https://openalex.org/W2883947381"],"abstract_inverted_index":{"Aspirin":[0],"and":[1,7,70,96,103,106,125,155,159,169,189,222],"clopidogrel":[2],"combined":[3,15],"irreversibly":[4],"inhibits":[5,9],"cyclooxygenase":[6],"reversibly":[8],"ADP":[10,154],"-dependent":[11],"platelet":[12,18,36,52,58,94,118,157,163,174,195,233],"aggregation.":[13,196],"The":[14],"effect":[16],"on":[17,100],"recruitment":[19,60,97,164,175],"is":[20,28],"not":[21,217],"described.":[22],"Individual":[23],"patient":[24,137],"response":[25],"to":[26,88,114],"therapy":[27,105,150],"measurable.":[29],"Thirty":[30],"chronic":[31],"ischemic":[32],"stroke":[33,134],"patients":[34,192,225],"had":[35],"reactivity":[37,234],"tests":[38],"performed":[39],"while":[40],"taking":[41],"aspirin":[42,101,187,220],"alone":[43,102],"followed":[44],"by":[45,61,65,73,194,227],"combination":[46,104,149,206],"aspirin-clopidogrel":[47,207],"over":[48,176,209],"3":[49],"months:":[50],"ex-vivo":[51],"aggregation":[53,95,158],"using":[54],"a":[55],"PAP":[56],"4":[57],"aggregometer,":[59],"the":[62],"method":[63],"described":[64],"Valles":[66],"et":[67],"al.,":[68],"[2002]":[69],"urinary":[71,184],"11-dhTxB2excretion":[72,185],"competitive":[74],"enzyme":[75],"linked":[76],"immunosorbent":[77],"assay.":[78],"Compliance":[79],"was":[80,138,143,181],"monitored.":[81],"Statistical":[82],"methods":[83,167],"included":[84],"analysis":[85,109],"of":[86,91,93,117,148,153,162,173,230,232],"variance":[87],"compare":[89],"variables":[90],"inhibition":[92,116,152,161,172,204,231],"between":[98,186,219],"those":[99],"longitudinal":[107],"regression":[108],"with":[110,205],"time":[111,210],"as":[112],"covariate":[113],"estimate":[115],"recruitment.":[119],"Non-linear":[120,197],"mapping":[121,198],"defined":[122,193,226],"variable":[123,201],"associations":[124],"interconnections":[126],"in":[127,146,183,211,238],"each":[128,239],"patient.":[129,240],"No":[130,178],"bleeding":[131],"or":[132],"recurrent":[133],"occurred.":[135],"One":[136],"non-compliant.":[139],"Statistically":[140],"significant":[141],"difference":[142,180],"found":[144,182],"(1)":[145],"favor":[147],"for":[151,165],"collagen-induced":[156],"maximum":[160],"all":[166],"tested,":[168],"(2)":[170],"increasing":[171],"time.":[177],"statistical":[179],"resistant":[188,191,221,224],"non":[190,223],"showed":[199],"patient-unique":[200],"interconnections.":[202],"Platelet":[203],"increases":[208],"most":[212],"patients.":[213],"Urinary":[214],"TxB2excretion":[215],"may":[216],"differentiate":[218],"other":[228],"measures":[229],"which":[235],"uniquely":[236],"connect":[237]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
