{"id":"https://openalex.org/W2304844648","doi":"https://doi.org/10.1109/icsenst.2015.7438361","title":"Graphene-based lectin biosensor for ultrasensitive detection of glycan structures applicable in early diagnostics","display_name":"Graphene-based lectin biosensor for ultrasensitive detection of glycan structures applicable in early diagnostics","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2304844648","doi":"https://doi.org/10.1109/icsenst.2015.7438361","mag":"2304844648"},"language":"en","primary_location":{"id":"doi:10.1109/icsenst.2015.7438361","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsenst.2015.7438361","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 9th International Conference on Sensing Technology (ICST)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034208796","display_name":"\u013dudmila Klukov\u00e1","orcid":null},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"funder","lineage":["https://openalex.org/I207624831"]}],"countries":["SK"],"is_corresponding":true,"raw_author_name":"L'udmila Klukova","raw_affiliation_strings":["Department of Glycobiotechnology, Slovak Academy of Sciences, Bratislava, slovakia"],"affiliations":[{"raw_affiliation_string":"Department of Glycobiotechnology, Slovak Academy of Sciences, Bratislava, slovakia","institution_ids":["https://openalex.org/I207624831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031925003","display_name":"Jaroslav Filip","orcid":"https://orcid.org/0000-0001-8838-2258"},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"funder","lineage":["https://openalex.org/I207624831"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Jaroslav Filip","raw_affiliation_strings":["Department of Glycobiotechnology, Slovak Academy of Sciences, Bratislava, slovakia"],"affiliations":[{"raw_affiliation_string":"Department of Glycobiotechnology, Slovak Academy of Sciences, Bratislava, slovakia","institution_ids":["https://openalex.org/I207624831"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069848572","display_name":"Jan Tk\u00e1\u010d","orcid":"https://orcid.org/0000-0002-0765-7262"},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"funder","lineage":["https://openalex.org/I207624831"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Jan Tkac","raw_affiliation_strings":["Department of Glycobiotechnology, Slovak Academy of Sciences, Bratislava, slovakia"],"affiliations":[{"raw_affiliation_string":"Department of Glycobiotechnology, Slovak Academy of Sciences, Bratislava, slovakia","institution_ids":["https://openalex.org/I207624831"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034208796"],"corresponding_institution_ids":["https://openalex.org/I207624831"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.1044142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"40","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10913","display_name":"Molecular Junctions and Nanostructures","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.9245909452438354},{"id":"https://openalex.org/keywords/glycan","display_name":"Glycan","score":0.8445667028427124},{"id":"https://openalex.org/keywords/lectin","display_name":"Lectin","score":0.7209798693656921},{"id":"https://openalex.org/keywords/analyte","display_name":"Analyte","score":0.6064294576644897},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.5386144518852234},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"Concanavalin A","score":0.4497617483139038},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.44761592149734497},{"id":"https://openalex.org/keywords/glycoprotein","display_name":"Glycoprotein","score":0.377416729927063},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3753419518470764},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.29248103499412537},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.259514182806015},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22764018177986145},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.16303402185440063}],"concepts":[{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.9245909452438354},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.8445667028427124},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.7209798693656921},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.6064294576644897},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5386144518852234},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.4497617483139038},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44761592149734497},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.377416729927063},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3753419518470764},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.29248103499412537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.259514182806015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22764018177986145},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.16303402185440063},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icsenst.2015.7438361","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsenst.2015.7438361","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 9th International Conference on Sensing Technology (ICST)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1967126372","https://openalex.org/W1977432663","https://openalex.org/W1979615826","https://openalex.org/W1982800374","https://openalex.org/W1992598822","https://openalex.org/W1999768858","https://openalex.org/W2014800504","https://openalex.org/W2014935324","https://openalex.org/W2020678155","https://openalex.org/W2030068202","https://openalex.org/W2032579136","https://openalex.org/W2042245003","https://openalex.org/W2051785799","https://openalex.org/W2053231021","https://openalex.org/W2060486468","https://openalex.org/W2064935054","https://openalex.org/W2077500248","https://openalex.org/W2078119700","https://openalex.org/W2097163573","https://openalex.org/W2100689542","https://openalex.org/W2130712482","https://openalex.org/W2150391637","https://openalex.org/W2163980958","https://openalex.org/W2312355907","https://openalex.org/W2313161765","https://openalex.org/W2318925422","https://openalex.org/W2414433378","https://openalex.org/W2414501786","https://openalex.org/W2963721992","https://openalex.org/W3022437245","https://openalex.org/W4210253570","https://openalex.org/W4232362978","https://openalex.org/W4293105400","https://openalex.org/W6766043127"],"related_works":["https://openalex.org/W2048091868","https://openalex.org/W2048150163","https://openalex.org/W1984286173","https://openalex.org/W2067069447","https://openalex.org/W2075907977","https://openalex.org/W2352827408","https://openalex.org/W2037741753","https://openalex.org/W2162603453","https://openalex.org/W4233442397","https://openalex.org/W1990616227"],"abstract_inverted_index":{"It":[0],"is":[1,72,170,177,226,236,262],"a":[2,36,126],"well-known":[3],"fact":[4],"that":[5,47,207,239],"various":[6],"pathological":[7],"conditions":[8],"result":[9],"in":[10,18,58,115,165,191,257],"an":[11],"increased":[12],"concentration":[13,231],"of":[14,65,69,83,91,112,121,175,183,194,214,220,232,246,251],"specific":[15,244],"substances":[16],"(biomarkers)":[17],"blood":[19],"or":[20,89,145],"urine.":[21],"Some":[22],"biomarkers":[23],"may":[24,34],"carry":[25],"on":[26],"their":[27],"surfaces":[28],"characteristic":[29],"saccharide":[30],"structures":[31],"(glycans),":[32],"which":[33,94,123,242],"have":[35,205],"different":[37,218],"structure":[38],"comparing":[39],"to":[40,101,139,197,228],"normal":[41],"(healthy)":[42],"physiological":[43],"condition.":[44],"This":[45],"means,":[46],"glycan":[48,157],"profiling":[49],"can":[50,95,161],"distinguish":[51],"between":[52],"healthy":[53],"and":[54,75,109,132,143,159,248],"sick":[55],"individuals":[56],"and,":[57],"some":[59],"cases,":[60],"even":[61,146,164],"determine":[62],"the":[63,66,119,168,173,181,192],"stage":[64],"disease.":[67],"Glycoprofiling":[68],"biological":[70],"samples":[71],"relatively":[73],"demanding":[74],"often":[76],"requires":[77],"complex":[78],"instrumentation.":[79],"In":[80,201],"addition,":[81],"many":[82],"currently":[84],"used":[85,163],"methods":[86,104],"involve":[87],"labelling":[88],"fragmentation":[90],"target":[92,169],"molecules,":[93],"eventually":[96],"influence":[97],"whole":[98,147],"analysis.":[99],"Contrary":[100],"this,":[102],"electrochemical":[103,240],"provide":[105],"very":[106,153],"sensitive,":[107],"rapid":[108],"simple":[110],"analysis":[111],"intact":[113],"glycoproteins":[114],"real":[116],"samples,":[117],"without":[118],"need":[120],"labelling,":[122],"makes":[124],"them":[125],"strong":[127],"tool":[128,211],"for":[129,156,212],"biosensor":[130,216,225],"construction":[131],"optimization.":[133],"Lectins":[134],"are":[135,152,209,254],"carbohydrate-binding":[136],"proteins":[137],"able":[138,227],"recognize":[140,229],"free,":[141],"mono-":[142],"oligosaccharides":[144],"cells.":[148],"Therefore,":[149],"lectin":[150,221],"biosensors":[151,176],"promising":[154],"candidates":[155],"analyses":[158],"they":[160],"be":[162],"case":[166],"when":[167],"unknown.":[171],"Nowadays,":[172],"term":[174],"inextricably":[178],"linked":[179],"with":[180],"concept":[182,261],"nanotechnology.":[184],"Since":[185],"2004,":[186],"graphene":[187,252],"attracts":[188],"worldwide":[189],"attention":[190],"field":[193],"(electro)biosensing":[195],"thanks":[196],"its":[198],"impressive":[199],"properties.":[200],"our":[202],"work":[203],"we":[204],"demonstrated":[206],"graphene-materials":[208],"prospective":[210],"fabrication":[213],"lectin-based":[215],"allowing":[217],"way":[219],"immobilization.":[222],"Moreover,":[223],"prepared":[224],"femtomolar":[230],"analyte.":[233],"Therefore":[234],"there":[235],"no":[237],"doubt,":[238],"biosensors,":[241],"combine":[243],"qualities":[245],"lectins":[247],"unique":[249],"features":[250],"materials,":[253],"innovative":[255],"approach":[256],"glycoprofiling,":[258],"yet":[259],"this":[260],"still":[263],"rare.":[264]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}