{"id":"https://openalex.org/W2736923812","doi":"https://doi.org/10.1109/icra.2017.7989635","title":"A high-precision robot-aided single-cell biopsy system","display_name":"A high-precision robot-aided single-cell biopsy system","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W2736923812","doi":"https://doi.org/10.1109/icra.2017.7989635","mag":"2736923812"},"language":"en","primary_location":{"id":"doi:10.1109/icra.2017.7989635","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icra.2017.7989635","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Robotics and Automation (ICRA)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032242387","display_name":"Adnan Shakoor","orcid":"https://orcid.org/0000-0003-0646-5231"},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Adnan Shakoor","raw_affiliation_strings":["Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101631595","display_name":"Tao Luo","orcid":"https://orcid.org/0000-0002-4861-3397"},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Tao Luo","raw_affiliation_strings":["Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023373913","display_name":"Shuxun Chen","orcid":"https://orcid.org/0000-0003-1113-2693"},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Shuxun Chen","raw_affiliation_strings":["Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030244622","display_name":"Mingyang Xie","orcid":"https://orcid.org/0000-0002-7636-480X"},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Mingyang Xie","raw_affiliation_strings":["Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001918826","display_name":"James K. Mills","orcid":"https://orcid.org/0000-0001-7651-9552"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James K. Mills","raw_affiliation_strings":["Department of Mechanical and Industrial Eng., University of Toronto5, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Eng., University of Toronto5, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100382905","display_name":"Dong Sun","orcid":"https://orcid.org/0000-0003-3945-4037"},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Dong Sun","raw_affiliation_strings":["Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"5397","last_page":"5402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micromanipulator","display_name":"Micromanipulator","score":0.8501006364822388},{"id":"https://openalex.org/keywords/pipette","display_name":"Pipette","score":0.6054962873458862},{"id":"https://openalex.org/keywords/foreskin","display_name":"Foreskin","score":0.5980701446533203},{"id":"https://openalex.org/keywords/biopsy","display_name":"Biopsy","score":0.5296993851661682},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.49566853046417236},{"id":"https://openalex.org/keywords/organelle","display_name":"Organelle","score":0.4848983883857727},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.46654486656188965},{"id":"https://openalex.org/keywords/fibroblast","display_name":"Fibroblast","score":0.43792325258255005},{"id":"https://openalex.org/keywords/robot","display_name":"Robot","score":0.4346058964729309},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.43059319257736206},{"id":"https://openalex.org/keywords/nucleus","display_name":"Nucleus","score":0.4183260500431061},{"id":"https://openalex.org/keywords/microfluidic-chip","display_name":"Microfluidic chip","score":0.41659823060035706},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39094534516334534},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.32324323058128357},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.23522350192070007},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2225407063961029},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.18833738565444946},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.18487170338630676},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.17631840705871582},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.17605388164520264},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15185025334358215},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.15075436234474182},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07351630926132202}],"concepts":[{"id":"https://openalex.org/C2776470464","wikidata":"https://www.wikidata.org/wiki/Q1933900","display_name":"Micromanipulator","level":2,"score":0.8501006364822388},{"id":"https://openalex.org/C151552171","wikidata":"https://www.wikidata.org/wiki/Q163373","display_name":"Pipette","level":2,"score":0.6054962873458862},{"id":"https://openalex.org/C2781140480","wikidata":"https://www.wikidata.org/wiki/Q673203","display_name":"Foreskin","level":3,"score":0.5980701446533203},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5296993851661682},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.49566853046417236},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.4848983883857727},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.46654486656188965},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.43792325258255005},{"id":"https://openalex.org/C90509273","wikidata":"https://www.wikidata.org/wiki/Q11012","display_name":"Robot","level":2,"score":0.4346058964729309},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.43059319257736206},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.4183260500431061},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.41659823060035706},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39094534516334534},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.32324323058128357},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23522350192070007},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2225407063961029},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.18833738565444946},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18487170338630676},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17631840705871582},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.17605388164520264},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15185025334358215},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15075436234474182},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07351630926132202},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icra.2017.7989635","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icra.2017.7989635","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Conference on Robotics and Automation (ICRA)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W636722593","https://openalex.org/W1487014009","https://openalex.org/W1537543043","https://openalex.org/W1966709725","https://openalex.org/W1970894097","https://openalex.org/W2001373220","https://openalex.org/W2024580346","https://openalex.org/W2036640181","https://openalex.org/W2059722429","https://openalex.org/W2066451902","https://openalex.org/W2067744732","https://openalex.org/W2109538121","https://openalex.org/W2136101105","https://openalex.org/W2155724270","https://openalex.org/W2288384663","https://openalex.org/W2315721109","https://openalex.org/W2337970408"],"related_works":["https://openalex.org/W2982566957","https://openalex.org/W2316748260","https://openalex.org/W2609000799","https://openalex.org/W2331733109","https://openalex.org/W2007063717","https://openalex.org/W4245822815","https://openalex.org/W1992169485","https://openalex.org/W2164407091","https://openalex.org/W1970453635","https://openalex.org/W2067546527"],"abstract_inverted_index":{"In":[0],"this":[1],"paper,":[2],"we":[3],"present":[4],"a":[5,39,43,72],"precise":[6],"robot-aided":[7],"single-cell":[8,13,56],"surgery":[9],"system":[10,59],"to":[11,26,51,87],"perform":[12,52],"biopsy":[14,101],"for":[15,106],"cells":[16,31,69,84],"<25":[17],"\u03bcm":[18],"in":[19,32,71],"diameter.":[20],"A":[21,35],"microfluidic":[22,73],"chip":[23],"is":[24,49,60,102],"designed":[25],"arrange":[27],"upto":[28],"100":[29],"individual":[30],"an":[33],"array.":[34],"micropipette":[36],"mounted":[37],"onto":[38],"3-DOF":[40],"micromanipulator":[41],"and":[42,54,78,104,108],"computer":[44],"mouse-operated":[45],"high-precision":[46,53],"XY":[47],"stage":[48],"developed":[50],"high-throughput":[55],"biopsy.":[57],"The":[58,75,95],"evaluated":[61],"experimentally":[62],"by":[63],"extracting":[64],"two":[65],"organelles":[66],"from":[67],"adherent":[68],"patterned":[70],"chip.":[74],"fluorescent-labeled":[76],"nucleus":[77,109],"mitochondria":[79],"of":[80,91,98],"human":[81],"foreskin":[82],"fibroblast":[83],"are":[85],"biopsied":[86],"demonstrate":[88],"the":[89,92,99],"capability":[90],"proposed":[93],"system.":[94],"survival":[96],"rate":[97],"semi-automated":[100],"73%":[103],"45%":[105],"mitochondrial":[107],"biopsies,":[110],"respectively.":[111]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}