{"id":"https://openalex.org/W4412742534","doi":"https://doi.org/10.1109/icps65515.2025.11087847","title":"Sepsis Detection Exploiting Biomarker Analysis with Deep Neural Networks","display_name":"Sepsis Detection Exploiting Biomarker Analysis with Deep Neural Networks","publication_year":2025,"publication_date":"2025-05-12","ids":{"openalex":"https://openalex.org/W4412742534","doi":"https://doi.org/10.1109/icps65515.2025.11087847"},"language":"en","primary_location":{"id":"doi:10.1109/icps65515.2025.11087847","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icps65515.2025.11087847","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 8th International Conference on Industrial Cyber-Physical Systems (ICPS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119010916","display_name":"Dimitrios Spanos","orcid":"https://orcid.org/0009-0005-4490-5332"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Dimitrios Spanos","raw_affiliation_strings":["Aristotle University of Thessaloniki,Computational Intelligence and Deep Learning Group, AIIA Lab,Dept. of Informatics,Thessaloniki,Greece"],"affiliations":[{"raw_affiliation_string":"Aristotle University of Thessaloniki,Computational Intelligence and Deep Learning Group, AIIA Lab,Dept. of Informatics,Thessaloniki,Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061050264","display_name":"Nikolaos Passalis","orcid":"https://orcid.org/0000-0003-1177-9139"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Passalis","raw_affiliation_strings":["Aristotle University of Thessaloniki,Dept. of Chemical Engineering,Thessaloniki,Greece"],"affiliations":[{"raw_affiliation_string":"Aristotle University of Thessaloniki,Dept. of Chemical Engineering,Thessaloniki,Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061175851","display_name":"Dimosthenis Spasopoulos","orcid":null},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimosthenis Spasopoulos","raw_affiliation_strings":["Aristotle University of Thessaloniki,Wireless and Photonic Systems and Networks Group,Dept. of Informatics,Thessaloniki,Greece"],"affiliations":[{"raw_affiliation_string":"Aristotle University of Thessaloniki,Wireless and Photonic Systems and Networks Group,Dept. of Informatics,Thessaloniki,Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051767233","display_name":"E. Chatzianagnostou","orcid":"https://orcid.org/0000-0002-9622-1208"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evangelia Chatzianagnostou","raw_affiliation_strings":["Aristotle University of Thessaloniki,Wireless and Photonic Systems and Networks Group,Dept. of Informatics,Thessaloniki,Greece"],"affiliations":[{"raw_affiliation_string":"Aristotle University of Thessaloniki,Wireless and Photonic Systems and Networks Group,Dept. of Informatics,Thessaloniki,Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077547848","display_name":"Juan Carlos Ruiz\u2010Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-7392-8617"},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127641"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Carlos Ruiz Rodr\u00edguez","raw_affiliation_strings":["Hospital Universitari Vall d'Hebron,Barcelona,Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Universitari Vall d'Hebron,Barcelona,Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Juan Jose Gonzalez Lopez","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127641"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Jose Gonzalez Lopez","raw_affiliation_strings":["Hospital Universitari Vall d'Hebron,Barcelona,Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Universitari Vall d'Hebron,Barcelona,Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057714878","display_name":"Laura M. Lechuga","orcid":"https://orcid.org/0000-0001-5187-5358"},"institutions":[{"id":"https://openalex.org/I4210093216","display_name":"Institut Catal\u00e0 de Nanoci\u00e8ncia i Nanotecnologia","ror":"https://ror.org/00k1qja49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I123044942","https://openalex.org/I134820265","https://openalex.org/I4210093216","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura M. Lechuga","raw_affiliation_strings":["Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, CIBER-BBN and BIST,Nanobiosensors and Bioanalytical Applications Group (NanoB2A),Bellaterra,Barcelona,Spain,08193"],"affiliations":[{"raw_affiliation_string":"Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, CIBER-BBN and BIST,Nanobiosensors and Bioanalytical Applications Group (NanoB2A),Bellaterra,Barcelona,Spain,08193","institution_ids":["https://openalex.org/I4210093216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073505057","display_name":"M.\u2010Carmen Est\u00e9vez","orcid":"https://orcid.org/0000-0003-3694-7186"},"institutions":[{"id":"https://openalex.org/I4210093216","display_name":"Institut Catal\u00e0 de Nanoci\u00e8ncia i Nanotecnologia","ror":"https://ror.org/00k1qja49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I123044942","https://openalex.org/I134820265","https://openalex.org/I4210093216","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M.-Carmen Est\u00e9vez","raw_affiliation_strings":["Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, CIBER-BBN and BIST,Nanobiosensors and Bioanalytical Applications Group (NanoB2A),Bellaterra,Barcelona,Spain,08193"],"affiliations":[{"raw_affiliation_string":"Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, CIBER-BBN and BIST,Nanobiosensors and Bioanalytical Applications Group (NanoB2A),Bellaterra,Barcelona,Spain,08193","institution_ids":["https://openalex.org/I4210093216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063280455","display_name":"Nikos Pleros","orcid":"https://orcid.org/0000-0003-2931-4540"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikos Pleros","raw_affiliation_strings":["Aristotle University of Thessaloniki,Wireless and Photonic Systems and Networks Group,Dept. of Informatics,Thessaloniki,Greece"],"affiliations":[{"raw_affiliation_string":"Aristotle University of Thessaloniki,Wireless and Photonic Systems and Networks Group,Dept. of Informatics,Thessaloniki,Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041054091","display_name":"Anastasios Tefas","orcid":"https://orcid.org/0000-0003-1288-3667"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasios Tefas","raw_affiliation_strings":["Aristotle University of Thessaloniki,Computational Intelligence and Deep Learning Group, AIIA Lab,Dept. of Informatics,Thessaloniki,Greece"],"affiliations":[{"raw_affiliation_string":"Aristotle University of Thessaloniki,Computational Intelligence and Deep Learning Group, AIIA Lab,Dept. of Informatics,Thessaloniki,Greece","institution_ids":["https://openalex.org/I21370196"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5119010916"],"corresponding_institution_ids":["https://openalex.org/I21370196"],"apc_list":null,"apc_paid":null,"fwci":1.1366,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.80444283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9294999837875366,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9294999837875366,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.6344964504241943},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6092642545700073},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5324512720108032},{"id":"https://openalex.org/keywords/sepsis","display_name":"Sepsis","score":0.5045379400253296},{"id":"https://openalex.org/keywords/deep-neural-networks","display_name":"Deep neural networks","score":0.45254963636398315},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4373813271522522},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.34577351808547974},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24994125962257385},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.14037200808525085},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07383498549461365}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6344964504241943},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6092642545700073},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5324512720108032},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5045379400253296},{"id":"https://openalex.org/C2984842247","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep neural networks","level":3,"score":0.45254963636398315},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4373813271522522},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34577351808547974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24994125962257385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14037200808525085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07383498549461365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icps65515.2025.11087847","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icps65515.2025.11087847","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 8th International Conference on Industrial Cyber-Physical Systems (ICPS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1933428198","https://openalex.org/W1967278969","https://openalex.org/W2055744632","https://openalex.org/W2079819154","https://openalex.org/W2101234009","https://openalex.org/W2161069658","https://openalex.org/W2280404143","https://openalex.org/W2610332124","https://openalex.org/W2744780151","https://openalex.org/W2888836219","https://openalex.org/W3181476437","https://openalex.org/W4399499402","https://openalex.org/W6631190155","https://openalex.org/W6775900539"],"related_works":["https://openalex.org/W3215560449","https://openalex.org/W3030236844","https://openalex.org/W2832459556","https://openalex.org/W2794721326","https://openalex.org/W4237737355","https://openalex.org/W1520457732","https://openalex.org/W4385384888","https://openalex.org/W2979695286","https://openalex.org/W1998617258","https://openalex.org/W2891360831"],"abstract_inverted_index":{"Machine":[0],"learning":[1,83],"has":[2],"found":[3],"widespread":[4],"application":[5],"in":[6,33],"many":[7],"domains,":[8],"including":[9],"medical":[10],"sciences,":[11],"offering":[12],"promising":[13],"solutions":[14],"to":[15,48,120],"complex":[16],"healthcare":[17],"challenges":[18],"using":[19],"cyber-physical":[20],"systems":[21],"(CPSs).":[22],"Although":[23],"mortality":[24],"rates":[25],"for":[26,57,66,86,160],"sepsis":[27,62,88,161],"and":[28,40,51,59,125,145,166],"septic":[29],"shock":[30],"have":[31],"declined":[32],"recent":[34],"years,":[35],"these":[36],"conditions":[37],"remain":[38],"critical":[39,65],"are":[41,64],"often":[42],"overlooked,":[43],"necessitating":[44],"advanced":[45],"predictive":[46],"modeling":[47],"enable":[49],"prompt":[50],"accurate":[52],"diagnosis.":[53],"Providing":[54],"informative":[55],"indicators":[56],"physicians":[58],"enabling":[60,163],"early":[61,87],"diagnosis":[63],"improving":[67],"patient":[68,168],"outcomes,":[69],"even":[70],"when":[71,90],"minimal":[72],"information":[73],"is":[74,97],"accessible.":[75],"In":[76],"this":[77],"paper,":[78],"we":[79,100],"present":[80],"a":[81,92,103,117,140,157],"deep":[82,153],"(DL)":[84],"pipeline":[85,107],"detection":[89],"only":[91],"limited":[93],"number":[94],"of":[95,116,132,143,152],"biomarkers":[96],"available.":[98],"Furthermore,":[99],"also":[101],"introduce":[102],"domain-guided":[104],"data":[105,123],"refinement":[106,126],"that":[108],"combines":[109],"prior":[110],"domain":[111],"knowledge":[112],"with":[113],"the":[114,122,130,133,150],"predictions":[115],"DL":[118],"model":[119],"guide":[121],"gathering":[124],"process.":[127],"We":[128],"demonstrate":[129],"effectiveness":[131],"proposed":[134],"approach":[135],"through":[136],"extensive":[137],"experiments":[138],"across":[139],"wide":[141],"range":[142],"settings":[144],"tasks.":[146],"Our":[147],"findings":[148],"show":[149],"potential":[151],"neural":[154],"networks":[155],"as":[156],"helpful":[158],"tool":[159],"diagnosis,":[162],"timely":[164],"interventions":[165],"better":[167],"care.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-04-23T09:07:50.710637","created_date":"2025-10-10T00:00:00"}