{"id":"https://openalex.org/W4402836100","doi":"https://doi.org/10.1109/icpm63005.2024.10680661","title":"Discovering Changes in Cell Stability Using Process Mining: A Case Study","display_name":"Discovering Changes in Cell Stability Using Process Mining: A Case Study","publication_year":2024,"publication_date":"2024-09-25","ids":{"openalex":"https://openalex.org/W4402836100","doi":"https://doi.org/10.1109/icpm63005.2024.10680661"},"language":"en","primary_location":{"id":"doi:10.1109/icpm63005.2024.10680661","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/icpm63005.2024.10680661","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 6th International Conference on Process Mining (ICPM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113401275","display_name":"Johnson Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Johnson Zhou","raw_affiliation_strings":["The University of Melbourne,Australia"],"affiliations":[{"raw_affiliation_string":"The University of Melbourne,Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050881323","display_name":"Abel Armas-Cervantes","orcid":"https://orcid.org/0000-0003-0628-2451"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Abel Armas-Cervantes","raw_affiliation_strings":["The University of Melbourne,Australia"],"affiliations":[{"raw_affiliation_string":"The University of Melbourne,Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019445580","display_name":"Zahra Dasht Bozorgi","orcid":"https://orcid.org/0000-0002-1595-3934"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Zahra Dasht Bozorgi","raw_affiliation_strings":["The University of Melbourne,Australia"],"affiliations":[{"raw_affiliation_string":"The University of Melbourne,Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025478640","display_name":"Ellen Otte","orcid":"https://orcid.org/0000-0002-3597-736X"},"institutions":[{"id":"https://openalex.org/I4210153402","display_name":"CSL (Australia)","ror":"https://ror.org/044tc0x05","country_code":"AU","type":"company","lineage":["https://openalex.org/I4210153402"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ellen Otte","raw_affiliation_strings":["CSL Limited,Australia"],"affiliations":[{"raw_affiliation_string":"CSL Limited,Australia","institution_ids":["https://openalex.org/I4210153402"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024929895","display_name":"Artem Polyvyanyy","orcid":"https://orcid.org/0000-0002-7672-1643"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Artem Polyvyanyy","raw_affiliation_strings":["The University of Melbourne,Australia"],"affiliations":[{"raw_affiliation_string":"The University of Melbourne,Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5113401275"],"corresponding_institution_ids":["https://openalex.org/I165779595"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24856406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"65","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10703","display_name":"Business Process Modeling and Analysis","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1404","display_name":"Management Information Systems"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10703","display_name":"Business Process Modeling and Analysis","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1404","display_name":"Management Information Systems"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.600782036781311},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5620893836021423},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.4345329999923706},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.18818539381027222}],"concepts":[{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.600782036781311},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5620893836021423},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4345329999923706},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.18818539381027222},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icpm63005.2024.10680661","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/icpm63005.2024.10680661","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 6th International Conference on Process Mining (ICPM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1843425376","https://openalex.org/W1996109622","https://openalex.org/W2026737836","https://openalex.org/W2102863299","https://openalex.org/W2158891129","https://openalex.org/W2995445261","https://openalex.org/W3049641726","https://openalex.org/W3114383424","https://openalex.org/W4221101188","https://openalex.org/W4225278948","https://openalex.org/W4243932450","https://openalex.org/W4387470101","https://openalex.org/W6637131181","https://openalex.org/W6731115184","https://openalex.org/W6772516087","https://openalex.org/W6796189547","https://openalex.org/W6853782413","https://openalex.org/W6921015902"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W2382290278","https://openalex.org/W4395014643"],"abstract_inverted_index":{"A":[0],"bioprocess":[1,40,74],"is":[2,41,67,82,122],"a":[3,14,44,47,116,137],"series":[4],"of":[5,29,36,50,62,88,128,181,189,220],"biological,":[6],"chemical,":[7],"and":[8,55,91,105,170],"physical":[9],"operations":[10],"used":[11,25,123,214],"to":[12,42,84,95,124,145,152,215],"produce":[13],"product":[15],"using":[16],"living":[17],"cells":[18,58,90],"or":[19],"their":[20,92],"components.":[21],"Bioprocesses":[22],"are":[23,61],"often":[24],"for":[26,168],"the":[27,37,51,70,77,86,89,126,132,154,179,182,209,217],"production":[28,39],"monoclonal":[30],"antibodies":[31],"(mAbs).":[32],"The":[33],"first":[34,148],"step":[35,66],"mAb":[38],"take":[43],"vial":[45],"containing":[46],"small":[48],"amount":[49],"selected":[52],"cell":[53,101,129,190],"line":[54],"grow":[56],"those":[57],"until":[59],"they":[60],"sufficient":[63],"quantity.":[64],"This":[65],"known":[68],"as":[69,98],"seed":[71,78,133,156,172,183,222],"train":[72,79,134,157,184],"in":[73,100,108,141,192,202],"development.":[75],"During":[76],"phase,":[80],"it":[81,149],"essential":[83],"monitor":[85],"stability":[87,127],"growth":[93,185,199,218],"due":[94],"challenges":[96],"such":[97],"variations":[99],"behaviour,":[102],"batch-to-batch":[103],"differences,":[104],"potential":[106],"changes":[107],"cultivation":[109],"conditions.":[110],"In":[111,143],"this":[112],"paper,":[113],"we":[114,206],"present":[115],"case":[117],"study":[118],"where":[119],"process":[120,164],"mining":[121],"analyse":[125],"lines":[130],"during":[131],"phase":[135],"at":[136],"large":[138],"pharmaceutical":[139],"company":[140],"Australia.":[142],"order":[144],"do":[146],"so,":[147],"was":[150],"necessary":[151],"transform":[153],"collected":[155],"data":[158],"into":[159,178],"an":[160],"event":[161],"log.":[162],"Next,":[163],"models":[165,211],"were":[166],"discovered":[167,210],"high-":[169],"low-growth":[171],"trains.":[173,223],"We":[174],"then":[175],"derived":[176],"insights":[177],"performance":[180,201,219],"rate":[186,200],"whereby":[187],"characteristics":[188],"cultures":[191],"early":[193],"stages":[194],"can":[195,212],"be":[196,213],"associated":[197],"with":[198],"later":[203],"stages.":[204],"Finally,":[205],"showed":[207],"how":[208],"predict":[216],"new":[221]},"counts_by_year":[],"updated_date":"2025-12-27T23:08:20.325037","created_date":"2025-10-10T00:00:00"}