{"id":"https://openalex.org/W2012286992","doi":"https://doi.org/10.1109/icnc.2010.5583621","title":"ICA-based feature extraction and automatic classification of AD-related MRI data","display_name":"ICA-based feature extraction and automatic classification of AD-related MRI data","publication_year":2010,"publication_date":"2010-08-01","ids":{"openalex":"https://openalex.org/W2012286992","doi":"https://doi.org/10.1109/icnc.2010.5583621","mag":"2012286992"},"language":"en","primary_location":{"id":"doi:10.1109/icnc.2010.5583621","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icnc.2010.5583621","pdf_url":null,"source":{"id":"https://openalex.org/S4363608012","display_name":"2010 Sixth International Conference on Natural Computation","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 Sixth International Conference on Natural Computation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101938499","display_name":"Wenlu Yang","orcid":"https://orcid.org/0000-0003-1800-5670"},"institutions":[{"id":"https://openalex.org/I96733725","display_name":"Shanghai Maritime University","ror":"https://ror.org/04z7qrj66","country_code":"CN","type":"education","lineage":["https://openalex.org/I96733725"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenlu Yang","raw_affiliation_strings":["Information Engineering College, Shanghai Maritime University, Shanghai, China","Information Engineering College, Shanghai Maritime University, 200135, China"],"affiliations":[{"raw_affiliation_string":"Information Engineering College, Shanghai Maritime University, Shanghai, China","institution_ids":["https://openalex.org/I96733725"]},{"raw_affiliation_string":"Information Engineering College, Shanghai Maritime University, 200135, China","institution_ids":["https://openalex.org/I96733725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109814296","display_name":"Xia Hong-qing","orcid":null},"institutions":[{"id":"https://openalex.org/I96733725","display_name":"Shanghai Maritime University","ror":"https://ror.org/04z7qrj66","country_code":"CN","type":"education","lineage":["https://openalex.org/I96733725"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Halei Xia","raw_affiliation_strings":["Information Engineering College, Shanghai Maritime University, Shanghai, China","Information Engineering College, Shanghai Maritime University, 200135, China"],"affiliations":[{"raw_affiliation_string":"Information Engineering College, Shanghai Maritime University, Shanghai, China","institution_ids":["https://openalex.org/I96733725"]},{"raw_affiliation_string":"Information Engineering College, Shanghai Maritime University, 200135, China","institution_ids":["https://openalex.org/I96733725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033321482","display_name":"Bin Xia","orcid":"https://orcid.org/0000-0002-9843-715X"},"institutions":[{"id":"https://openalex.org/I96733725","display_name":"Shanghai Maritime University","ror":"https://ror.org/04z7qrj66","country_code":"CN","type":"education","lineage":["https://openalex.org/I96733725"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Xia","raw_affiliation_strings":["Information Engineering College, Shanghai Maritime University, Shanghai, China","Information Engineering College, Shanghai Maritime University, 200135, China"],"affiliations":[{"raw_affiliation_string":"Information Engineering College, Shanghai Maritime University, Shanghai, China","institution_ids":["https://openalex.org/I96733725"]},{"raw_affiliation_string":"Information Engineering College, Shanghai Maritime University, 200135, China","institution_ids":["https://openalex.org/I96733725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046845149","display_name":"Lok Ming Lui","orcid":"https://orcid.org/0000-0002-9152-0743"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lok Ming Lui","raw_affiliation_strings":["Department of Mathematics, Harvard University, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Harvard University, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080825168","display_name":"Xudong Huang","orcid":"https://orcid.org/0000-0002-4811-1901"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xudong Huang","raw_affiliation_strings":["Department of Radiology, Brigham\uc2a0and\uc2a0Women''s Hospital and Harvard Medical School, Boston, MA, USA","Department of Radiology, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA,"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Brigham\uc2a0and\uc2a0Women''s Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Radiology, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA,","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101938499"],"corresponding_institution_ids":["https://openalex.org/I96733725"],"apc_list":null,"apc_paid":null,"fwci":3.7581,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.96891192,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1261","last_page":"1265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11447","display_name":"Blind Source Separation Techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1711","display_name":"Signal Processing"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11447","display_name":"Blind Source Separation Techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1711","display_name":"Signal Processing"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9646000266075134,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.7979031801223755},{"id":"https://openalex.org/keywords/independent-component-analysis","display_name":"Independent component analysis","score":0.7829959392547607},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.630180299282074},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.5211548805236816},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4958113133907318},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.48337191343307495},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.4520842134952545},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.431964635848999},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.41017472743988037},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.33738577365875244},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.336492657661438},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.22231295704841614},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.22039076685905457},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.20291787385940552},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.18024277687072754}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.7979031801223755},{"id":"https://openalex.org/C51432778","wikidata":"https://www.wikidata.org/wiki/Q1259145","display_name":"Independent component analysis","level":2,"score":0.7829959392547607},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.630180299282074},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5211548805236816},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4958113133907318},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.48337191343307495},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4520842134952545},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.431964635848999},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.41017472743988037},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33738577365875244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.336492657661438},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.22231295704841614},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22039076685905457},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20291787385940552},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18024277687072754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icnc.2010.5583621","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icnc.2010.5583621","pdf_url":null,"source":{"id":"https://openalex.org/S4363608012","display_name":"2010 Sixth International Conference on Natural Computation","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 Sixth International Conference on Natural Computation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7200000286102295}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320326300","display_name":"Shanghai Maritime University","ror":"https://ror.org/04z7qrj66"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W118779735","https://openalex.org/W1973637437","https://openalex.org/W2036162736","https://openalex.org/W2046121601","https://openalex.org/W2062930198","https://openalex.org/W2068066990","https://openalex.org/W2078563723","https://openalex.org/W2103402739","https://openalex.org/W2105687940","https://openalex.org/W2111913931","https://openalex.org/W2119720840","https://openalex.org/W2119821739","https://openalex.org/W2119848633","https://openalex.org/W2123720427","https://openalex.org/W2141224535","https://openalex.org/W2143826137","https://openalex.org/W2150534249","https://openalex.org/W2155710233","https://openalex.org/W2171831801","https://openalex.org/W4239510810"],"related_works":["https://openalex.org/W4252230435","https://openalex.org/W2121429698","https://openalex.org/W2182042810","https://openalex.org/W55679925","https://openalex.org/W3080404860","https://openalex.org/W2046761971","https://openalex.org/W3144722888","https://openalex.org/W2089650474","https://openalex.org/W2364896863","https://openalex.org/W2389189059"],"abstract_inverted_index":{"There":[0],"is":[1,99,184],"an":[2,118],"unmet":[3],"medical":[4],"need":[5],"for":[6,10,25,136,165],"identifying":[7,137],"neuroimaging":[8,92,140,169],"biomarkers":[9,22,93],"Alzheimer's":[11],"disease":[12],"(AD),":[13],"the":[14,45,163,172,198,202],"most":[15],"common":[16],"form":[17],"of":[18,30,33,38,44,128,206],"senile":[19],"dementia.":[20],"These":[21],"are":[23,152],"essential":[24],"early":[26],"and":[27,36,49,66,77,154,189,218],"accurate":[28],"diagnosis":[29],"AD,":[31],"monitoring":[32],"AD":[34,76,91,139,188,217],"progression,":[35],"assessment":[37],"AD-modifying":[39],"therapies.":[40],"In":[41],"volumetric":[42],"studies":[43],"medial":[46],"temporal":[47],"lobe":[48],"hippocampus,":[50],"magnetic":[51,95],"resonance":[52,96],"imaging":[53],"(MRI),":[54],"as":[55],"a":[56,101,109,167,180],"technique":[57,124],"that":[58,125,183,210,211],"can":[59,215],"detect":[60],"changes":[61],"in":[62],"cerebral":[63],"blood":[64,67],"flow":[65],"oxygenation,":[68],"has":[69,145],"shown":[70],"its":[71],"powerful":[72],"ability":[73],"to":[74,88,162,186],"distinguish":[75],"mild":[78],"cognitive":[79],"impairment":[80],"(MCI)":[81],"subjects":[82],"from":[83,94,191,201,221],"normal":[84],"controls.":[85,223],"However,":[86],"how":[87],"identify":[89],"potential":[90,138,168],"(MR)":[97],"images":[98,164],"still":[100],"very":[102],"challenging":[103],"task.":[104],"We":[105],"have":[106],"thus":[107],"proposed":[108],"novel":[110],"method":[111,144,214],"based":[112],"on":[113,197],"independent":[114,134,174],"component":[115,175],"analysis":[116],"(ICA),":[117],"increasingly":[119],"important":[120],"biomedical":[121],"signal":[122],"processing":[123],"enables":[126],"separation":[127],"blindly":[129],"observed":[130],"signals":[131,135],"into":[132,179],"original":[133],"biomarker(s).":[141],"The":[142,194],"ICA-based":[143,213],"three":[146],"steps.":[147],"First,":[148],"all":[149],"MRI":[150,199],"scans":[151],"aligned":[153],"normalized":[155],"by":[156],"SPM.":[157],"Then,":[158],"ICA":[159],"was":[160],"applied":[161],"extracting":[166],"biomarker.":[170],"Finally,":[171],"separated":[173],"coefficients":[176],"were":[177],"fed":[178],"classifying":[181],"machine":[182],"able":[185],"discrinate":[187],"MCI":[190,219],"control":[192],"subjects.":[193],"experimental":[195],"results":[196],"data":[200],"Open":[203],"Access":[204],"Series":[205],"Imaging":[207],"Studies":[208],"showed":[209],"our":[212],"discern":[216],"cases":[220],"agematched":[222]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}