{"id":"https://openalex.org/W4389077792","doi":"https://doi.org/10.1109/icmlc58545.2023.10327966","title":"Impairment of LTP, LTD and Metaplasticity During the Early Stages of Alzheimer'S Disease: a Computational Study","display_name":"Impairment of LTP, LTD and Metaplasticity During the Early Stages of Alzheimer'S Disease: a Computational Study","publication_year":2023,"publication_date":"2023-07-09","ids":{"openalex":"https://openalex.org/W4389077792","doi":"https://doi.org/10.1109/icmlc58545.2023.10327966"},"language":"en","primary_location":{"id":"doi:10.1109/icmlc58545.2023.10327966","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icmlc58545.2023.10327966","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 International Conference on Machine Learning and Cybernetics (ICMLC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070937245","display_name":"Azam Shirrafiardekani","orcid":"https://orcid.org/0000-0003-2172-4422"},"institutions":[{"id":"https://openalex.org/I4210142395","display_name":"Torrens University Australia","ror":"https://ror.org/0351xae06","country_code":"AU","type":"education","lineage":["https://openalex.org/I4210142395"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Azam Shirrafiardekani","raw_affiliation_strings":["Torrens University,Faculty of Information Technology,Melbourne,Australia","Faculty of Information Technology, Torrens University, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torrens University,Faculty of Information Technology,Melbourne,Australia","institution_ids":["https://openalex.org/I4210142395"]},{"raw_affiliation_string":"Faculty of Information Technology, Torrens University, Melbourne, Australia","institution_ids":["https://openalex.org/I4210142395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016064500","display_name":"Hany Alashwal","orcid":"https://orcid.org/0000-0002-5721-5104"},"institutions":[{"id":"https://openalex.org/I201726411","display_name":"United Arab Emirates University","ror":"https://ror.org/01km6p862","country_code":"AE","type":"education","lineage":["https://openalex.org/I201726411"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Hany Alashwal","raw_affiliation_strings":["College of Information Technology, United Arab Emirates University,Al-Ain,UAE,15551"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Technology, United Arab Emirates University,Al-Ain,UAE,15551","institution_ids":["https://openalex.org/I201726411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026110190","display_name":"Ahmed A. Moustafa","orcid":"https://orcid.org/0000-0001-5971-273X"},"institutions":[{"id":"https://openalex.org/I120125038","display_name":"Bond University","ror":"https://ror.org/006jxzx88","country_code":"AU","type":"education","lineage":["https://openalex.org/I120125038"]},{"id":"https://openalex.org/I24027795","display_name":"University of Johannesburg","ror":"https://ror.org/04z6c2n17","country_code":"ZA","type":"education","lineage":["https://openalex.org/I24027795"]}],"countries":["AU","ZA"],"is_corresponding":false,"raw_author_name":"Ahmed A. Moustafa","raw_affiliation_strings":["University of Johannesburg,The Faculty of Health Sciences,Department of Human Anatomy and Physiology,South Africa","Department of Human Anatomy and Physiology, The Faculty of Health Sciences, University of Johannesburg, South Africa","Faculty of Society and Design, School of Psychology, Bond University, Gold Coast, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Johannesburg,The Faculty of Health Sciences,Department of Human Anatomy and Physiology,South Africa","institution_ids":["https://openalex.org/I24027795"]},{"raw_affiliation_string":"Department of Human Anatomy and Physiology, The Faculty of Health Sciences, University of Johannesburg, South Africa","institution_ids":["https://openalex.org/I24027795"]},{"raw_affiliation_string":"Faculty of Society and Design, School of Psychology, Bond University, Gold Coast, Queensland, Australia","institution_ids":["https://openalex.org/I120125038"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29302103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"165","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"Long-term potentiation","score":0.8860242366790771},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6715362071990967},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5803775787353516},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.5680152177810669},{"id":"https://openalex.org/keywords/ltp-induction","display_name":"LTP induction","score":0.5598353147506714},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.5454907417297363},{"id":"https://openalex.org/keywords/metaplasticity","display_name":"Metaplasticity","score":0.46595650911331177},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.42344266176223755},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3353957235813141},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18937405943870544},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.10515615344047546}],"concepts":[{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.8860242366790771},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6715362071990967},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5803775787353516},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5680152177810669},{"id":"https://openalex.org/C2776328245","wikidata":"https://www.wikidata.org/wiki/Q6460191","display_name":"LTP induction","level":4,"score":0.5598353147506714},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5454907417297363},{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.46595650911331177},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.42344266176223755},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3353957235813141},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18937405943870544},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10515615344047546}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/icmlc58545.2023.10327966","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icmlc58545.2023.10327966","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 International Conference on Machine Learning and Cybernetics (ICMLC)","raw_type":"proceedings-article"},{"id":"pmh:oai:https://pure.bond.edu.au/:publications/edd9d3f6-7330-43a2-bde5-b43c2db9e378","is_oa":false,"landing_page_url":"https://research.bond.edu.au/en/publications/edd9d3f6-7330-43a2-bde5-b43c2db9e378","pdf_url":null,"source":{"id":"https://openalex.org/S4306402608","display_name":"Bond University Research Portal (Bond University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I120125038","host_organization_name":"Bond University","host_organization_lineage":["https://openalex.org/I120125038"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1915192275","https://openalex.org/W1978476811","https://openalex.org/W1980872345","https://openalex.org/W2006905953","https://openalex.org/W2006941707","https://openalex.org/W2008546071","https://openalex.org/W2021051417","https://openalex.org/W2050066016","https://openalex.org/W2050496541","https://openalex.org/W2052742260","https://openalex.org/W2136901555","https://openalex.org/W2140899588","https://openalex.org/W2165658101","https://openalex.org/W2277356999","https://openalex.org/W2580439276","https://openalex.org/W2612757330","https://openalex.org/W2733677077","https://openalex.org/W2736586270","https://openalex.org/W2755642617","https://openalex.org/W2770626086","https://openalex.org/W2792275641","https://openalex.org/W3002611824","https://openalex.org/W3010695687","https://openalex.org/W3119354786","https://openalex.org/W3128420673","https://openalex.org/W3129663130","https://openalex.org/W3167086193","https://openalex.org/W3213455732","https://openalex.org/W6682940159"],"related_works":["https://openalex.org/W1533021419","https://openalex.org/W2012865678","https://openalex.org/W1908141284","https://openalex.org/W1869756662","https://openalex.org/W2354919283","https://openalex.org/W2498336718","https://openalex.org/W1606601164","https://openalex.org/W2138310310","https://openalex.org/W2069591992","https://openalex.org/W2117410733"],"abstract_inverted_index":{"Alzheimer's":[0,93,110,144],"disease":[1,111],"is":[2,9,60,70],"a":[3,15,45,67,115],"common":[4],"form":[5],"of":[6,14,28,51,76,84,92,101,109,133,143],"dementia":[7],"that":[8,98],"caused":[10],"by":[11],"the":[12,21,32,49,52,74,82,89,99,106,131,134,141],"accumulation":[13],"protein":[16,24],"called":[17],"amyloid":[18],"beta":[19],"in":[20,31,48,117,122,125],"brain.":[22],"This":[23],"impairs":[25],"certain":[26],"mechanisms":[27],"information":[29],"processing":[30],"brain,":[33],"such":[34],"as":[35],"long-term":[36,40],"potentiation":[37],"(LTP)":[38],"and":[39,86,119],"depression":[41],"(LTD),":[42],"which":[43,129],"play":[44],"critical":[46],"role":[47],"development":[50,132],"disease.":[53,94,135,145],"The":[54,95],"exact":[55],"mechanism":[56],"underlying":[57],"this":[58,65],"effect":[59,75],"not":[61],"yet":[62],"known.":[63],"In":[64],"study,":[66],"computational":[68],"model":[69],"used":[71],"to":[72,114],"investigate":[73],"blocking":[77],"various":[78],"potassium":[79,103],"channels":[80,104],"on":[81],"impairment":[83],"LTP":[85,118],"LTD":[87,123],"during":[88,105],"early":[90,107],"stages":[91,108],"results":[96],"suggest":[97],"blockage":[100],"specific":[102],"can":[112],"lead":[113],"reduction":[116],"an":[120],"increase":[121],"induction":[124],"dentate":[126],"granule":[127],"cells,":[128],"accelerates":[130],"These":[136],"findings":[137],"have":[138],"implications":[139],"for":[140],"treatment":[142]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
