{"id":"https://openalex.org/W2123204745","doi":"https://doi.org/10.1109/icmens.2004.1509010","title":"Anti-Retroviral Vaccine Using Polymeric Nanoparticles","display_name":"Anti-Retroviral Vaccine Using Polymeric Nanoparticles","publication_year":2006,"publication_date":"2006-10-11","ids":{"openalex":"https://openalex.org/W2123204745","doi":"https://doi.org/10.1109/icmens.2004.1509010","mag":"2123204745"},"language":"en","primary_location":{"id":"doi:10.1109/icmens.2004.1509010","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icmens.2004.1509010","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101545974","display_name":"Mitsuru Akashi","orcid":"https://orcid.org/0000-0002-7835-8198"},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Akashi","raw_affiliation_strings":["Department of Molecular Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan","Japan Science and Technology Agency (JST), Core Research of Evolutional Science and Technology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Japan Science and Technology Agency (JST), Core Research of Evolutional Science and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I4210086780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082580301","display_name":"Takami Akagi","orcid":"https://orcid.org/0000-0003-0268-1922"},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Akagi","raw_affiliation_strings":["Department of Molecular Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan","Japan Science and Technology Agency (JST), Core Research of Evolutional Science and Technology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Japan Science and Technology Agency (JST), Core Research of Evolutional Science and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I4210086780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054769661","display_name":"Tatsuo Kaneko","orcid":"https://orcid.org/0000-0001-9794-083X"},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Kaneko","raw_affiliation_strings":["Department of Molecular Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan","Japan Science and Technology Agency (JST), Core Research of Evolutional Science and Technology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Japan Science and Technology Agency (JST), Core Research of Evolutional Science and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I4210086780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080592581","display_name":"Masanori Baba","orcid":"https://orcid.org/0000-0002-6109-5248"},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210086780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Baba","raw_affiliation_strings":["Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan","Japan Science and Technology Agency (JST), Core Research of Evolutional Science and Technology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan","institution_ids":["https://openalex.org/I107139324"]},{"raw_affiliation_string":"Japan Science and Technology Agency (JST), Core Research of Evolutional Science and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I4210086780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111977440","display_name":"Masanori Hayami","orcid":null},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Hayami","raw_affiliation_strings":["Laboratory of Primates Model, Experimental Research Center for Infectious Disease, Institute for Virus Research, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Primates Model, Experimental Research Center for Infectious Disease, Institute for Virus Research, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11903637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"161","issue":null,"first_page":"556","last_page":"562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunization","display_name":"Immunization","score":0.722490668296814},{"id":"https://openalex.org/keywords/macaque","display_name":"Macaque","score":0.7159459590911865},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"Simian immunodeficiency virus","score":0.696707010269165},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.678870677947998},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.5708925724029541},{"id":"https://openalex.org/keywords/rhesus-macaque","display_name":"Rhesus macaque","score":0.5390599966049194},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.4775717556476593},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.4736819565296173},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.46829476952552795},{"id":"https://openalex.org/keywords/virus-like-particle","display_name":"Virus-like particle","score":0.4456421434879303},{"id":"https://openalex.org/keywords/nasal-administration","display_name":"Nasal administration","score":0.43699929118156433},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.412672758102417},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32662373781204224}],"concepts":[{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.722490668296814},{"id":"https://openalex.org/C2778950215","wikidata":"https://www.wikidata.org/wiki/Q177601","display_name":"Macaque","level":2,"score":0.7159459590911865},{"id":"https://openalex.org/C2777995582","wikidata":"https://www.wikidata.org/wiki/Q1890246","display_name":"Simian immunodeficiency virus","level":3,"score":0.696707010269165},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.678870677947998},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5708925724029541},{"id":"https://openalex.org/C2779175743","wikidata":"https://www.wikidata.org/wiki/Q156606","display_name":"Rhesus macaque","level":2,"score":0.5390599966049194},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4775717556476593},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.4736819565296173},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46829476952552795},{"id":"https://openalex.org/C2776387124","wikidata":"https://www.wikidata.org/wiki/Q1475781","display_name":"Virus-like particle","level":4,"score":0.4456421434879303},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.43699929118156433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.412672758102417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32662373781204224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icmens.2004.1509010","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icmens.2004.1509010","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1549087352","https://openalex.org/W1577158615","https://openalex.org/W1605208680","https://openalex.org/W1952668055","https://openalex.org/W1977796860","https://openalex.org/W1978271591","https://openalex.org/W1988835951","https://openalex.org/W2027387554","https://openalex.org/W2049795920","https://openalex.org/W2050354809","https://openalex.org/W2054827263","https://openalex.org/W2064250642","https://openalex.org/W2069080281","https://openalex.org/W2070868926","https://openalex.org/W2075848378","https://openalex.org/W2076423932","https://openalex.org/W2082672496","https://openalex.org/W2088569914","https://openalex.org/W2120697664","https://openalex.org/W2127436087","https://openalex.org/W2135953287","https://openalex.org/W2149791183","https://openalex.org/W2158511077","https://openalex.org/W2301522255","https://openalex.org/W2325597058","https://openalex.org/W2330902358","https://openalex.org/W2407214482","https://openalex.org/W2418159708","https://openalex.org/W6714123322"],"related_works":["https://openalex.org/W2357501381","https://openalex.org/W2412402955","https://openalex.org/W2070813973","https://openalex.org/W2159552369","https://openalex.org/W2007287624","https://openalex.org/W1755520082","https://openalex.org/W2747845282","https://openalex.org/W2105944190","https://openalex.org/W31547710","https://openalex.org/W2076700278"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"reported":[3],"that":[4,17,124],"concanavalin":[5],"A-immobilized":[6],"polystyrene":[7],"nanospheres":[8,24,60],"(Con":[9],"A-NS)":[10],"could":[11],"efficiently":[12],"capture":[13],"HIV-1":[14],"particles":[15],"and":[16,62,82,105,129],"intranasal":[18],"immunization":[19],"with":[20,50,66,144],"inactivated":[21,54],"HIV-1-":[22],"capturing":[23,59],"(HIV-NS)":[25],"induced":[26],"vaginal":[27,78,142],"anti-HIV-1":[28,79],"IgA":[29,81],"antibody":[30],"response":[31],"in":[32,87,99,117,125],"mice.":[33],"In":[34],"this":[35],"study,":[36],"to":[37,141],"evaluate":[38],"the":[39,96,102,132],"protective":[40],"effect":[41],"of":[42,75,95,101,114],"immunization,":[43],"each":[44,100],"three":[45,97],"macaques":[46,98,119,137],"was":[47,108,120],"intranasally":[48],"immunized":[49],"Con":[51,103],"A-NS":[52],"or":[53],"simian/human":[55],"immunodeficiency":[56],"virus":[57],"KU-2-":[58],"(SHIV-NS)":[61],"then":[63],"intravaginally":[64],"challenged":[65],"a":[67,73],"pathogenic":[68],"virus,":[69],"SHIV":[70,145],"KU-2.":[71,146],"After":[72,91],"series":[74],"six":[76],"immunizations,":[77],"gp120":[80],"IgG":[83],"antibodies":[84],"were":[85],"detected":[86],"all":[88],"SHIV-NS-immunized":[89,106,118,136],"macaques.":[90],"intravaginal":[92],"challenge,":[93],"one":[94],"A-NS-":[104],"groups":[107],"infected.":[109],"Plasma":[110],"viral":[111],"RNA":[112],"load":[113],"infected":[115],"macaque":[116,128],"substantially":[121],"less":[122],"than":[123],"unimmunized":[126],"control":[127],"reached":[130],"below":[131],"detectable":[133],"level.":[134],"Thus,":[135],"exhibited":[138],"partial":[139],"protection":[140],"challenges":[143]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
