{"id":"https://openalex.org/W7129607457","doi":"https://doi.org/10.1109/icipw68931.2025.11385907","title":"Toward Real-Time Tcspc-Flim: Unconstrained Pile-Up Correction Method for Distortion-Free Measurements at Extreme Count Rates","display_name":"Toward Real-Time Tcspc-Flim: Unconstrained Pile-Up Correction Method for Distortion-Free Measurements at Extreme Count Rates","publication_year":2025,"publication_date":"2025-09-14","ids":{"openalex":"https://openalex.org/W7129607457","doi":"https://doi.org/10.1109/icipw68931.2025.11385907"},"language":"en","primary_location":{"id":"doi:10.1109/icipw68931.2025.11385907","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icipw68931.2025.11385907","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Image Processing Workshops (ICIPW)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062000513","display_name":"Ivan Rech","orcid":"https://orcid.org/0000-0002-1430-1010"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Ivan Rech","raw_affiliation_strings":["Politecnico di Milano, via Golgi 40,Dipartimento di Elettronica, Informazione e Bioingegneria,Milan,Italy,20133"],"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, via Golgi 40,Dipartimento di Elettronica, Informazione e Bioingegneria,Milan,Italy,20133","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113337462","display_name":"Piergiorgio Daniele","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piergiorgio Daniele","raw_affiliation_strings":["Politecnico di Milano, via Golgi 40,Dipartimento di Elettronica, Informazione e Bioingegneria,Milan,Italy,20133"],"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, via Golgi 40,Dipartimento di Elettronica, Informazione e Bioingegneria,Milan,Italy,20133","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099044231","display_name":"Gennaro Fratta","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gennaro Fratta","raw_affiliation_strings":["Politecnico di Milano, via Golgi 40,Dipartimento di Elettronica, Informazione e Bioingegneria,Milan,Italy,20133"],"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, via Golgi 40,Dipartimento di Elettronica, Informazione e Bioingegneria,Milan,Italy,20133","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076399608","display_name":"Ivan Labanca","orcid":"https://orcid.org/0000-0001-7011-3527"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ivan Labanca","raw_affiliation_strings":["Politecnico di Milano, via Golgi 40,Dipartimento di Elettronica, Informazione e Bioingegneria,Milan,Italy,20133"],"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, via Golgi 40,Dipartimento di Elettronica, Informazione e Bioingegneria,Milan,Italy,20133","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126233530","display_name":"Valerio Gandolf","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valerio Gandolf","raw_affiliation_strings":["Politecnico di Milano, Piazza Leonardo da Vinci 32,Dipartimento di Fisica,Milan,Italy,20133"],"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, Piazza Leonardo da Vinci 32,Dipartimento di Fisica,Milan,Italy,20133","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029963728","display_name":"Federico Simoni","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federico Simoni","raw_affiliation_strings":["Politecnico di Milano, Piazza Leonardo da Vinci 32,Dipartimento di Fisica,Milan,Italy,20133"],"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, Piazza Leonardo da Vinci 32,Dipartimento di Fisica,Milan,Italy,20133","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070716251","display_name":"Andrea Farina","orcid":"https://orcid.org/0000-0002-3180-6328"},"institutions":[{"id":"https://openalex.org/I4210134310","display_name":"Istituto di Fotonica e Nanotecnologie","ror":"https://ror.org/049ebw417","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210134310","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Farina","raw_affiliation_strings":["Istituto di Fotonica e Nanotecnologie,Consiglio Nazionale delle Ricerche, Piazza Leonardo da Vinci 32,Milan,Italy,20133"],"affiliations":[{"raw_affiliation_string":"Istituto di Fotonica e Nanotecnologie,Consiglio Nazionale delle Ricerche, Piazza Leonardo da Vinci 32,Milan,Italy,20133","institution_ids":["https://openalex.org/I4210134310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123021417","display_name":"Cosimo D\u2019Andrea","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cosimo D\u2019Andrea","raw_affiliation_strings":["Politecnico di Milano, Piazza Leonardo da Vinci 32,Dipartimento di Fisica,Milan,Italy,20133"],"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, Piazza Leonardo da Vinci 32,Dipartimento di Fisica,Milan,Italy,20133","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040933634","display_name":"Giulia Acconcia","orcid":"https://orcid.org/0000-0003-3190-4953"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Acconcia","raw_affiliation_strings":["Politecnico di Milano, via Golgi 40,Dipartimento di Elettronica, Informazione e Bioingegneria,Milan,Italy,20133"],"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, via Golgi 40,Dipartimento di Elettronica, Informazione e Bioingegneria,Milan,Italy,20133","institution_ids":["https://openalex.org/I93860229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5062000513"],"corresponding_institution_ids":["https://openalex.org/I93860229"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71519638,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"452","last_page":"457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12153","display_name":"Advanced Optical Sensing Technologies","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/3105","display_name":"Instrumentation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12153","display_name":"Advanced Optical Sensing Technologies","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/3105","display_name":"Instrumentation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.17430000007152557,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11992","display_name":"CCD and CMOS Imaging Sensors","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/detector","display_name":"Detector","score":0.6837999820709229},{"id":"https://openalex.org/keywords/photon-counting","display_name":"Photon counting","score":0.6766999959945679},{"id":"https://openalex.org/keywords/data-acquisition","display_name":"Data acquisition","score":0.5849000215530396},{"id":"https://openalex.org/keywords/dead-time","display_name":"Dead time","score":0.48890000581741333},{"id":"https://openalex.org/keywords/temporal-resolution","display_name":"Temporal resolution","score":0.47760000824928284},{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"Fluorescence-lifetime imaging microscopy","score":0.4323999881744385},{"id":"https://openalex.org/keywords/compressed-sensing","display_name":"Compressed sensing","score":0.41019999980926514},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.397599995136261}],"concepts":[{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.6837999820709229},{"id":"https://openalex.org/C2781402376","wikidata":"https://www.wikidata.org/wiki/Q17126172","display_name":"Photon counting","level":3,"score":0.6766999959945679},{"id":"https://openalex.org/C163985040","wikidata":"https://www.wikidata.org/wiki/Q1172399","display_name":"Data acquisition","level":2,"score":0.5849000215530396},{"id":"https://openalex.org/C159484563","wikidata":"https://www.wikidata.org/wiki/Q628723","display_name":"Dead time","level":2,"score":0.48890000581741333},{"id":"https://openalex.org/C119666444","wikidata":"https://www.wikidata.org/wiki/Q5977280","display_name":"Temporal resolution","level":2,"score":0.47760000824928284},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45260000228881836},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.4323999881744385},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.4221999943256378},{"id":"https://openalex.org/C124851039","wikidata":"https://www.wikidata.org/wiki/Q2665459","display_name":"Compressed sensing","level":2,"score":0.41019999980926514},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.397599995136261},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.3912999927997589},{"id":"https://openalex.org/C159317903","wikidata":"https://www.wikidata.org/wiki/Q3198","display_name":"Photon","level":2,"score":0.38089999556541443},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.36820000410079956},{"id":"https://openalex.org/C3261483","wikidata":"https://www.wikidata.org/wiki/Q119565","display_name":"Frame rate","level":2,"score":0.3610000014305115},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36039999127388},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.3538999855518341},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.32850000262260437},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.31130000948905945},{"id":"https://openalex.org/C2776141515","wikidata":"https://www.wikidata.org/wiki/Q1274479","display_name":"Repetition (rhetorical device)","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C47785574","wikidata":"https://www.wikidata.org/wiki/Q373859","display_name":"Two-photon excitation microscopy","level":3,"score":0.29789999127388},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C83581075","wikidata":"https://www.wikidata.org/wiki/Q1361503","display_name":"Excitation","level":2,"score":0.2822999954223633},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C76935873","wikidata":"https://www.wikidata.org/wiki/Q209121","display_name":"Image sensor","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.25209999084472656}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/icipw68931.2025.11385907","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icipw68931.2025.11385907","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Image Processing Workshops (ICIPW)","raw_type":"proceedings-article"},{"id":"pmh:oai:re.public.polimi.it:11311/1308045","is_oa":false,"landing_page_url":"https://hdl.handle.net/11311/1308045","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W771328121","https://openalex.org/W1969575569","https://openalex.org/W1992489841","https://openalex.org/W2043529114","https://openalex.org/W2911222514","https://openalex.org/W2951309741","https://openalex.org/W3025520212","https://openalex.org/W3120580457","https://openalex.org/W4387250066","https://openalex.org/W4398172297"],"related_works":[],"abstract_inverted_index":{"Fluorescence":[0],"Lifetime":[1],"Imaging":[2],"Microscopy":[3],"(FLIM)":[4],"is":[5,37,116],"a":[6,75,101,147,157,163],"powerful":[7],"tool":[8],"for":[9,41,59],"investigating":[10],"biological":[11],"and":[12,46],"physiological":[13],"processes":[14],"down":[15],"to":[16,123,132],"the":[17,22,38,106,136,183],"subcellular":[18],"level,":[19],"by":[20,119],"leveraging":[21],"temporal":[23,44],"properties":[24],"of":[25,108,135,182],"weak":[26],"fluorescence":[27,188],"signals.":[28],"Among":[29],"photon":[30,129,177],"detection":[31,152],"techniques,":[32],"Time-Correlated":[33],"Single-Photon":[34],"Counting":[35],"(TCSPC)":[36],"gold":[39],"standard":[40],"achieving":[42,176],"high":[43],"resolution":[45],"sensitivity.":[47],"However,":[48,111],"traditional":[49],"TCSPC":[50,125],"systems":[51],"historically":[52],"suffer":[53],"from":[54],"slow":[55],"acquisition":[56,63,85,112],"speed,":[57],"especially":[58],"large-field":[60],"imaging.":[61],"Wide-field":[62],"using":[64],"parallel":[65],"detector":[66],"arrays":[67],"increases":[68],"hardware":[69],"complexity,":[70],"while":[71],"single-pixel":[72],"detectors":[73],"offer":[74],"simpler":[76],"alternative":[77],"but":[78],"rely":[79],"on":[80],"spatial":[81],"scanning,":[82],"which":[83,127],"prolongs":[84],"times.":[86],"In":[87,140],"this":[88,141],"context,":[89],"Single-Pixel":[90],"Cameras":[91],"(SPCs)":[92],"combined":[93],"with":[94,162,186],"Compressive":[95],"Sensing":[96],"(CS)":[97],"have":[98],"emerged":[99],"as":[100,154],"cost-effective":[102],"solution,":[103],"significantly":[104],"reducing":[105],"number":[107],"required":[109],"measurements.":[110],"speed":[113],"in":[114],"SPC-FLIM":[115],"fundamentally":[117],"limited":[118],"pile-up":[120,165],"effects":[121],"inherent":[122],"conventional":[124],"systems,":[126],"restrict":[128],"count":[130,178],"rates":[131,179],"below":[133],"5%":[134],"laser":[137],"repetition":[138],"frequency.":[139],"work,":[142],"we":[143],"demonstrate":[144],"that":[145],"integrating":[146],"custom":[148],"ultra-low":[149],"dead":[150],"time":[151],"module":[153],"SPC":[155],"into":[156],"wide-field":[158],"FLIM":[159],"system,":[160],"along":[161],"novel":[164],"correction":[166],"algorithm,":[167],"enables":[168],"video-rate":[169],"imaging":[170],"at":[171],"20":[172],"frames":[173],"per":[174],"second":[175],"exceeding":[180],"200%":[181],"excitation":[184],"frequency,":[185],"minimal":[187],"lifetime":[189],"estimation":[190],"error.":[191]},"counts_by_year":[],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2026-02-18T00:00:00"}