{"id":"https://openalex.org/W1652227029","doi":"https://doi.org/10.1109/icinfa.2015.7279683","title":"Analysis of the islets-based glucose control system involving the nonlinear glucose-insulin metabolism model","display_name":"Analysis of the islets-based glucose control system involving the nonlinear glucose-insulin metabolism model","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W1652227029","doi":"https://doi.org/10.1109/icinfa.2015.7279683","mag":"1652227029"},"language":"en","primary_location":{"id":"doi:10.1109/icinfa.2015.7279683","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icinfa.2015.7279683","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Information and Automation","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101798494","display_name":"Liu Bao","orcid":"https://orcid.org/0009-0002-8315-9449"},"institutions":[{"id":"https://openalex.org/I4210162190","display_name":"China University of Petroleum, East China","ror":"https://ror.org/05gbn2817","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bao Liu","raw_affiliation_strings":["College of Information & Control Engineering, China University of Petroleum, Qingdao, China","College of Information and Control Engineering, China University of Petroleum, Qingdao, 266580, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information & Control Engineering, China University of Petroleum, Qingdao, China","institution_ids":["https://openalex.org/I4210162190"]},{"raw_affiliation_string":"College of Information and Control Engineering, China University of Petroleum, Qingdao, 266580, China","institution_ids":["https://openalex.org/I4210162190"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082640513","display_name":"Hao Ying","orcid":"https://orcid.org/0000-0002-4891-6785"},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Ying","raw_affiliation_strings":["Department of Electrical & Computer Engineering, Wayne State University, Detroit, Michigan, USA","Department of Electrical and Computer Engineering, Wayne State University, Detroit, Michigan 48202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, Wayne State University, Detroit, Michigan, USA","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Wayne State University, Detroit, Michigan 48202, USA","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0399137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"13","issue":null,"first_page":"2373","last_page":"2378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/setpoint","display_name":"Setpoint","score":0.9816761016845703},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.8618636131286621},{"id":"https://openalex.org/keywords/pid-controller","display_name":"PID controller","score":0.7297894954681396},{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.6829395890235901},{"id":"https://openalex.org/keywords/blood-sugar-regulation","display_name":"Blood sugar regulation","score":0.6490899920463562},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.5281051397323608},{"id":"https://openalex.org/keywords/linearization","display_name":"Linearization","score":0.5219585299491882},{"id":"https://openalex.org/keywords/lyapunov-function","display_name":"Lyapunov function","score":0.46387067437171936},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.43197235465049744},{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.42465314269065857},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.40942949056625366},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4011896252632141},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.28548479080200195},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2399405539035797},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.1595093011856079},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14997774362564087},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.13572174310684204},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.12327247858047485},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.11786672472953796},{"id":"https://openalex.org/keywords/temperature-control","display_name":"Temperature control","score":0.09691765904426575},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.06241488456726074}],"concepts":[{"id":"https://openalex.org/C12302492","wikidata":"https://www.wikidata.org/wiki/Q1752097","display_name":"Setpoint","level":2,"score":0.9816761016845703},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.8618636131286621},{"id":"https://openalex.org/C47116090","wikidata":"https://www.wikidata.org/wiki/Q716829","display_name":"PID controller","level":3,"score":0.7297894954681396},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.6829395890235901},{"id":"https://openalex.org/C76923068","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Blood sugar regulation","level":3,"score":0.6490899920463562},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.5281051397323608},{"id":"https://openalex.org/C11210021","wikidata":"https://www.wikidata.org/wiki/Q1520713","display_name":"Linearization","level":3,"score":0.5219585299491882},{"id":"https://openalex.org/C60640748","wikidata":"https://www.wikidata.org/wiki/Q2337858","display_name":"Lyapunov function","level":3,"score":0.46387067437171936},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.43197235465049744},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.42465314269065857},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.40942949056625366},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4011896252632141},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.28548479080200195},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2399405539035797},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1595093011856079},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14997774362564087},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.13572174310684204},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12327247858047485},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11786672472953796},{"id":"https://openalex.org/C536315585","wikidata":"https://www.wikidata.org/wiki/Q7698332","display_name":"Temperature control","level":2,"score":0.09691765904426575},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.06241488456726074},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icinfa.2015.7279683","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icinfa.2015.7279683","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Conference on Information and Automation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W15494515","https://openalex.org/W1844237527","https://openalex.org/W1964153860","https://openalex.org/W1992115775","https://openalex.org/W1995133123","https://openalex.org/W2001273251","https://openalex.org/W2004481735","https://openalex.org/W2005701142","https://openalex.org/W2016357432","https://openalex.org/W2018471296","https://openalex.org/W2042237861","https://openalex.org/W2077307326","https://openalex.org/W2094729684","https://openalex.org/W2098465489","https://openalex.org/W2102340435","https://openalex.org/W2102725663","https://openalex.org/W2117748324","https://openalex.org/W2130841496","https://openalex.org/W2141248178","https://openalex.org/W2142962347","https://openalex.org/W2160052863","https://openalex.org/W2167628970","https://openalex.org/W2168091777","https://openalex.org/W2545689486","https://openalex.org/W6638874522"],"related_works":["https://openalex.org/W1495927848","https://openalex.org/W4205962020","https://openalex.org/W1527771352","https://openalex.org/W90946887","https://openalex.org/W172676736","https://openalex.org/W2667392788","https://openalex.org/W2169601993","https://openalex.org/W2022616255","https://openalex.org/W1971292522","https://openalex.org/W1652227029"],"abstract_inverted_index":{"Maintaining":[0],"blood":[1],"glucose":[2,27,39,53,84,172],"concentration":[3],"within":[4],"a":[5,71,139,161],"normal":[6,26],"range":[7,140],"is":[8,68,92,174,183],"very":[9],"important":[10,175],"to":[11,24,110,115,133],"diabetic":[12],"patients.":[13],"Many":[14],"control":[15,41],"algorithms,":[16],"including":[17],"the":[18,36,44,48,65,81,96,99,108,111,116,123,128,150,155],"PID":[19,157],"method,":[20],"have":[21],"been":[22],"proposed":[23],"restore":[25],"tolerance":[28],"via":[29],"closed-loop":[30],"insulin":[31,55],"regulation.":[32],"This":[33],"paper":[34],"analyzes":[35],"physiologically":[37],"plausible":[38],"feedback":[40],"system":[42],"involving":[43],"islets-based":[45,66,82,151],"controller":[46,67,100,112,152,158],"and":[47,54,64,101,114,169,176],"nonlinear":[49],"pharmacokinetic":[50],"model":[51,58],"for":[52,138],"interactions.":[56],"The":[57],"consists":[59],"of":[60,98,119,141],"six":[61],"differential":[62],"equations,":[63],"represented":[69],"by":[70,95,160],"sigmoidal":[72],"function.":[73],"Our":[74],"study":[75,147],"reveals":[76],"that,":[77],"unlike":[78],"most":[79],"controllers,":[80],"controller's":[83],"setpoint":[85,109,142],"cannot":[86],"be":[87],"explicitly":[88],"set":[89],"because":[90],"it":[91],"implicitly":[93],"determined":[94],"parameters":[97],"model.":[102,124],"We":[103,125,164],"establish":[104],"mathematical":[105],"formulas":[106],"relating":[107],"gain":[113],"steady":[117],"states":[118],"other":[120],"variables":[121],"in":[122,180],"also":[126],"use":[127],"Lyapunov's":[129],"linearization":[130],"stability":[131,137],"criterion":[132],"investigate":[134],"system's":[135],"local":[136],"values.":[143],"Finally,":[144],"our":[145],"simulation":[146],"shows":[148],"that":[149,166,181],"moderately":[153],"outperforms":[154],"linear":[156],"optimized":[159],"genetic":[162],"algorithm.":[163],"conclude":[165],"developing":[167],"more":[168],"better":[170],"physiologically-inspired":[171],"controllers":[173],"promising.":[177],"More":[178],"research":[179],"direction":[182],"needed.":[184]},"counts_by_year":[{"year":2020,"cited_by_count":2}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
