{"id":"https://openalex.org/W2768858593","doi":"https://doi.org/10.1109/iceee.2017.8108870","title":"Simulation and in vivo validation of craniotomies in rats for the disruption of the blood brain barrier with focused ultrasound for drug delivery","display_name":"Simulation and in vivo validation of craniotomies in rats for the disruption of the blood brain barrier with focused ultrasound for drug delivery","publication_year":2017,"publication_date":"2017-10-01","ids":{"openalex":"https://openalex.org/W2768858593","doi":"https://doi.org/10.1109/iceee.2017.8108870","mag":"2768858593"},"language":"en","primary_location":{"id":"doi:10.1109/iceee.2017.8108870","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iceee.2017.8108870","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 14th International Conference on Electrical Engineering, Computing Science and Automatic Control (CCE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101878324","display_name":"Diego Hernandez","orcid":"https://orcid.org/0000-0002-4019-4626"},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Center for Research and Advanced Studies of the National Polytechnic Institute","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]},{"id":"https://openalex.org/I4210165005","display_name":"BioElectronics (United States)","ror":"https://ror.org/05mh3a113","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165005"]}],"countries":["MX","US"],"is_corresponding":true,"raw_author_name":"D. A. Hern\u00e1ndez","raw_affiliation_strings":["Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de México, México","Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de M\u00e9xico, M\u00e9xico"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de México, México","institution_ids":["https://openalex.org/I68368234","https://openalex.org/I4210165005"]},{"raw_affiliation_string":"Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067207076","display_name":"M. I. Guti\u00e9rrez","orcid":"https://orcid.org/0000-0001-8113-5932"},"institutions":[{"id":"https://openalex.org/I4210141776","display_name":"China XD Group (China)","ror":"https://ror.org/04ceqst84","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210141776"]},{"id":"https://openalex.org/I4210124243","display_name":"Instituto Nacional de Rehabilitaci\u00f3n","ror":"https://ror.org/03734cd59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210124243"]}],"countries":["CN","MX"],"is_corresponding":false,"raw_author_name":"M. I. Guti\u00e9rrez","raw_affiliation_strings":["CONACYT - Instituto Nacional de Rehabilitación, División de Investigación en Ingeniería Médica, Ciudad de México, México","Divisi\u00f3n de Investigaci\u00f3n en Ingenier\u00eda M\u00e9dica, Instituto Nacional de Rehabilitaci\u00f3n, Ciudad de M\u00e9xico, M\u00e9xico"],"affiliations":[{"raw_affiliation_string":"CONACYT - Instituto Nacional de Rehabilitación, División de Investigación en Ingeniería Médica, Ciudad de México, México","institution_ids":["https://openalex.org/I4210141776"]},{"raw_affiliation_string":"Divisi\u00f3n de Investigaci\u00f3n en Ingenier\u00eda M\u00e9dica, Instituto Nacional de Rehabilitaci\u00f3n, Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I4210124243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062028226","display_name":"A. Vera","orcid":"https://orcid.org/0000-0001-6258-154X"},"institutions":[{"id":"https://openalex.org/I4210165005","display_name":"BioElectronics (United States)","ror":"https://ror.org/05mh3a113","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165005"]},{"id":"https://openalex.org/I68368234","display_name":"Center for Research and Advanced Studies of the National Polytechnic Institute","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX","US"],"is_corresponding":false,"raw_author_name":"A. Vera","raw_affiliation_strings":["Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de México, México","Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de M\u00e9xico, M\u00e9xico"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de México, México","institution_ids":["https://openalex.org/I68368234","https://openalex.org/I4210165005"]},{"raw_affiliation_string":"Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063097729","display_name":"Daniel Mart\u00ednez\u2010Fong","orcid":"https://orcid.org/0000-0002-2934-8380"},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Center for Research and Advanced Studies of the National Polytechnic Institute","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"D. Mart\u00ednez-Fong","raw_affiliation_strings":["Department of Physiology, Biophysics and Neuroscience, CINVESTAV-IPN, Ciudad de México, México","Department of Physiology, Biophysics and Neuroscience, CINVESTAV-IPN, Ciudad de M\u00e9exico, M\u00e9xico"],"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biophysics and Neuroscience, CINVESTAV-IPN, Ciudad de México, México","institution_ids":["https://openalex.org/I68368234"]},{"raw_affiliation_string":"Department of Physiology, Biophysics and Neuroscience, CINVESTAV-IPN, Ciudad de M\u00e9exico, M\u00e9xico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008103986","display_name":"L. Leija","orcid":"https://orcid.org/0000-0001-8437-6520"},"institutions":[{"id":"https://openalex.org/I4210165005","display_name":"BioElectronics (United States)","ror":"https://ror.org/05mh3a113","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165005"]},{"id":"https://openalex.org/I68368234","display_name":"Center for Research and Advanced Studies of the National Polytechnic Institute","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX","US"],"is_corresponding":false,"raw_author_name":"L. Leija","raw_affiliation_strings":["Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de México, México","Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de M\u00e9xico, M\u00e9xico"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de México, México","institution_ids":["https://openalex.org/I68368234","https://openalex.org/I4210165005"]},{"raw_affiliation_string":"Department of Electrical Engineering/Bioelectronics, CINVESTAV-IPN, Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I68368234"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101878324"],"corresponding_institution_ids":["https://openalex.org/I4210165005","https://openalex.org/I68368234"],"apc_list":null,"apc_paid":null,"fwci":0.2549,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.55995173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/craniotomy","display_name":"Craniotomy","score":0.7451351284980774},{"id":"https://openalex.org/keywords/blood\u2013brain-barrier","display_name":"Blood\u2013brain barrier","score":0.7398848533630371},{"id":"https://openalex.org/keywords/focused-ultrasound","display_name":"Focused ultrasound","score":0.6361535787582397},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.5860500335693359},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.5753105282783508},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.5431004166603088},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.535148024559021},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.489983469247818},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4623139798641205},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3802468776702881},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.27374327182769775},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.21644645929336548},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2046787142753601},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1436956524848938},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.12983188033103943},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.09237194061279297}],"concepts":[{"id":"https://openalex.org/C2778871575","wikidata":"https://www.wikidata.org/wiki/Q514921","display_name":"Craniotomy","level":2,"score":0.7451351284980774},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7398848533630371},{"id":"https://openalex.org/C2985948822","wikidata":"https://www.wikidata.org/wiki/Q564897","display_name":"Focused ultrasound","level":3,"score":0.6361535787582397},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5860500335693359},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5753105282783508},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5431004166603088},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.535148024559021},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.489983469247818},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4623139798641205},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3802468776702881},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.27374327182769775},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.21644645929336548},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2046787142753601},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1436956524848938},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.12983188033103943},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.09237194061279297},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iceee.2017.8108870","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iceee.2017.8108870","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 14th International Conference on Electrical Engineering, Computing Science and Automatic Control (CCE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W117124504","https://openalex.org/W198884885","https://openalex.org/W1542236846","https://openalex.org/W2052263326","https://openalex.org/W2070472280","https://openalex.org/W2079621433","https://openalex.org/W2091752229","https://openalex.org/W2101170263","https://openalex.org/W2123555875","https://openalex.org/W2156360500","https://openalex.org/W2161323379","https://openalex.org/W2167405280","https://openalex.org/W2485806232","https://openalex.org/W2500553815","https://openalex.org/W2559558429","https://openalex.org/W2734658427","https://openalex.org/W6663780595"],"related_works":["https://openalex.org/W1979570000","https://openalex.org/W1975454920","https://openalex.org/W2116304792","https://openalex.org/W2017952116","https://openalex.org/W2167739272","https://openalex.org/W2396190916","https://openalex.org/W3124167690","https://openalex.org/W305134995","https://openalex.org/W2055722942","https://openalex.org/W2888942619"],"abstract_inverted_index":{"The":[0,59],"blood":[1,12],"brain":[2,57,115],"barrier":[3],"(BBB)":[4],"is":[5,38,91],"a":[6,39,69,100,139,151],"specialized":[7],"membrane":[8],"that":[9,150],"covers":[10],"the":[11,15,22,29,32,47,50,55,73,81,87,92,103,108,111,157,162],"vessel":[13],"in":[14,41,76,113,126],"central":[16],"nervous":[17],"system.":[18],"This":[19,97],"structure":[20],"regulates":[21],"passage":[23,51],"of":[24,52,61,83,86,89,95,102,110,119,134,142,153,167],"certain":[25],"substances":[26],"for":[27,43,72,116],"keeping":[28],"homeostasis":[30],"into":[31],"brain.":[33],"But":[34],"this":[35],"selective":[36],"permeability":[37],"drawback":[40],"treatments":[42],"neurodegenerative":[44],"diseases,":[45],"because":[46],"BBB":[48,74,112],"prevents":[49],"drugs":[53],"to":[54,67,159],"affected":[56],"cells.":[58],"use":[60],"focused":[62],"ultrasound":[63],"(FUS)":[64],"has":[65],"proven":[66],"be":[68,160],"promising":[70],"tool":[71],"disruption":[75,109],"specific":[77],"zones,":[78],"which":[79],"improves":[80],"release":[82],"drugs.":[84],"One":[85],"problems":[88],"FUS":[90,132],"high":[93],"attenuation":[94],"cranium.":[96],"paper":[98],"presents":[99],"study":[101],"acoustic":[104],"field":[105,171],"pattern":[106],"and":[107,138,173],"rat's":[114],"different":[117],"diameters":[118],"craniotomies.":[120],"These":[121],"experiments":[122],"were":[123],"carried":[124],"out":[125],"rats":[127],"wistar.":[128],"A":[129],"2":[130],"MHz":[131],"transducer":[133],"10":[135],"mm":[136,144],"radius":[137],"focal":[140],"length":[141],"20":[143],"was":[145,148],"used.":[146],"It":[147],"found":[149],"craniotomy":[152],"1":[154],"cm":[155],"allows":[156],"focus":[158],"on":[161],"substantia":[163],"nigra,":[164],"our":[165],"area":[166],"interest,":[168],"without":[169],"excessive":[170],"distortion":[172],"transmission":[174],"losses.":[175]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}