{"id":"https://openalex.org/W2888857850","doi":"https://doi.org/10.1109/ice.2018.8436259","title":"Control of Dynamically Inherent Biological Processes in Cell Technolog","display_name":"Control of Dynamically Inherent Biological Processes in Cell Technolog","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2888857850","doi":"https://doi.org/10.1109/ice.2018.8436259","mag":"2888857850"},"language":"en","primary_location":{"id":"doi:10.1109/ice.2018.8436259","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ice.2018.8436259","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Engineering, Technology and Innovation (ICE/ITMC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103382357","display_name":"Adam Malik","orcid":null},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Adam Malik","raw_affiliation_strings":["Laboratory for Machine Tools and Production Engineering (WZL), RWTH Aachen University, Aachen, Germany"],"affiliations":[{"raw_affiliation_string":"Laboratory for Machine Tools and Production Engineering (WZL), RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091633436","display_name":"Ulrike Meyr","orcid":null},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrike Meyr","raw_affiliation_strings":["Laboratory for Machine Tools and Production Engineering (WZL), RWTH Aachen University, Aachen, Germany"],"affiliations":[{"raw_affiliation_string":"Laboratory for Machine Tools and Production Engineering (WZL), RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025682940","display_name":"Werner Herfs","orcid":null},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Werner Herfs","raw_affiliation_strings":["Laboratory for Machine Tools and Production Engineering (WZL), RWTH Aachen University, Aachen, Germany"],"affiliations":[{"raw_affiliation_string":"Laboratory for Machine Tools and Production Engineering (WZL), RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004290451","display_name":"Martin Zenke","orcid":"https://orcid.org/0000-0002-1107-3251"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Zenke","raw_affiliation_strings":["Institute for Biomedical Engineering, Medical School, Aachen, Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering, Medical School, Aachen, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040328173","display_name":"Paul Wanek","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Wanek","raw_affiliation_strings":["Institute for Biomedical Engineering, Medical School, Aachen, Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering, Medical School, Aachen, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103382357"],"corresponding_institution_ids":["https://openalex.org/I887968799"],"apc_list":null,"apc_paid":null,"fwci":0.2179,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.52020433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9850000143051147,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7402891516685486},{"id":"https://openalex.org/keywords/automation","display_name":"Automation","score":0.6816156506538391},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.583808958530426},{"id":"https://openalex.org/keywords/scheduling","display_name":"Scheduling (production processes)","score":0.5721562504768372},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.5216546654701233},{"id":"https://openalex.org/keywords/process-control","display_name":"Process control","score":0.4616367518901825},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.37262648344039917},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.33776307106018066},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.33398759365081787},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.13709726929664612},{"id":"https://openalex.org/keywords/operations-management","display_name":"Operations management","score":0.0827227532863617},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07826504111289978}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7402891516685486},{"id":"https://openalex.org/C115901376","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automation","level":2,"score":0.6816156506538391},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.583808958530426},{"id":"https://openalex.org/C206729178","wikidata":"https://www.wikidata.org/wiki/Q2271896","display_name":"Scheduling (production processes)","level":2,"score":0.5721562504768372},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5216546654701233},{"id":"https://openalex.org/C155386361","wikidata":"https://www.wikidata.org/wiki/Q1649571","display_name":"Process control","level":3,"score":0.4616367518901825},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.37262648344039917},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.33776307106018066},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.33398759365081787},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13709726929664612},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0827227532863617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07826504111289978},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ice.2018.8436259","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ice.2018.8436259","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Conference on Engineering, Technology and Innovation (ICE/ITMC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1506083024","https://openalex.org/W2014671464","https://openalex.org/W2040481376","https://openalex.org/W2048361578","https://openalex.org/W2050179565","https://openalex.org/W2050383997","https://openalex.org/W2050928873","https://openalex.org/W2063799401","https://openalex.org/W2110462752","https://openalex.org/W2128362126","https://openalex.org/W2151906117","https://openalex.org/W2166660685","https://openalex.org/W2293544059","https://openalex.org/W2330628472","https://openalex.org/W6662591197","https://openalex.org/W6662807966"],"related_works":["https://openalex.org/W2997567050","https://openalex.org/W2519676117","https://openalex.org/W1483272040","https://openalex.org/W4283377908","https://openalex.org/W1533421371","https://openalex.org/W2218202131","https://openalex.org/W2003050223","https://openalex.org/W84108837","https://openalex.org/W2091777911","https://openalex.org/W2766405861"],"abstract_inverted_index":{"The":[0,114,155],"cultivation":[1,173],"of":[2,31,36,78,104,110,116,143,146],"human":[3],"cells":[4,83,106],"for":[5,14,74,123],"diagnostic":[6],"or":[7,80,98],"biomedical":[8],"applications":[9],"is":[10,112],"an":[11,23],"interesting":[12],"topic":[13],"the":[15,32,105,165],"automation":[16,20],"industry.":[17],"However,":[18],"classical":[19,71],"concepts":[21],"using":[22,159],"imperative":[24],"programming":[25],"paradigm":[26],"reach":[27],"their":[28],"limits":[29],"because":[30],"inherent":[33],"dynamical":[34],"behavior":[35],"donor":[37],"specific":[38],"cells.":[39],"In":[40,68],"particular":[41],"sophisticated":[42],"cell":[43,50,66,147,172],"culture":[44,85,148],"processes,":[45,149],"such":[46],"as":[47,120],"many":[48],"stem":[49],"technologies,":[51],"have":[52],"still":[53],"to":[54,70,88,133],"be":[55],"executed":[56],"manually,":[57],"which":[58,73],"renders":[59],"them":[60],"labor":[61],"intensive":[62],"and":[63,92,125,152],"causes":[64],"varying":[65],"quality.":[67],"contrast":[69],"products,":[72],"example":[75],"are":[76,86],"made":[77],"metal":[79],"plastic,":[81],"living":[82],"in":[84,90,135],"subject":[87],"changes":[89],"growth":[91],"functional":[93],"properties":[94],"depending":[95],"on":[96],"internal":[97],"external":[99],"stimuli.":[100],"Therefore,":[101],"constant":[102],"observation":[103],"over":[107],"extended":[108],"periods":[109],"time":[111],"necessary.":[113],"evaluation":[115],"these":[117],"observations":[118],"serves":[119],"a":[121,140,160,171],"basis":[122],"decision-making":[124],"online":[126],"process":[127,130,150,162],"adaptation.":[128],"Finally,":[129],"adaptation":[131],"leads":[132],"adjustments":[134],"scheduling.":[136,154],"This":[137],"paper":[138],"presents":[139],"novel":[141],"concept":[142,156],"rule-based":[144],"modeling":[145],"adaption":[151],"dynamic":[153],"was":[157],"validated":[158],"general":[161],"chain":[163],"including":[164],"most":[166],"common":[167],"decision":[168],"situation":[169],"within":[170],"process.":[174]},"counts_by_year":[{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}