{"id":"https://openalex.org/W4404030890","doi":"https://doi.org/10.1109/icccnt61001.2024.10723857","title":"Identification of Natural Compounds as P-Glycoprotein Substrates and its Effect on Drug Distribution: An In-Silico Study","display_name":"Identification of Natural Compounds as P-Glycoprotein Substrates and its Effect on Drug Distribution: An In-Silico Study","publication_year":2024,"publication_date":"2024-06-24","ids":{"openalex":"https://openalex.org/W4404030890","doi":"https://doi.org/10.1109/icccnt61001.2024.10723857"},"language":"en","primary_location":{"id":"doi:10.1109/icccnt61001.2024.10723857","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/icccnt61001.2024.10723857","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 15th International Conference on Computing Communication and Networking Technologies (ICCCNT)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101235655","display_name":"Swagata Mukhopadhyay","orcid":null},"institutions":[{"id":"https://openalex.org/I55862774","display_name":"West Bengal State University","ror":"https://ror.org/04qs5en05","country_code":"IN","type":"education","lineage":["https://openalex.org/I55862774"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Swagata Mukhopadhyay","raw_affiliation_strings":["West Bengal State University,Department of Physiology,Kolkata,India,700126"],"affiliations":[{"raw_affiliation_string":"West Bengal State University,Department of Physiology,Kolkata,India,700126","institution_ids":["https://openalex.org/I55862774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063587229","display_name":"Chandana Roy","orcid":"https://orcid.org/0000-0003-3294-894X"},"institutions":[{"id":"https://openalex.org/I55862774","display_name":"West Bengal State University","ror":"https://ror.org/04qs5en05","country_code":"IN","type":"education","lineage":["https://openalex.org/I55862774"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chandana Roy","raw_affiliation_strings":["West Bengal State University,Department of Physiology,Kolkata,India,700126"],"affiliations":[{"raw_affiliation_string":"West Bengal State University,Department of Physiology,Kolkata,India,700126","institution_ids":["https://openalex.org/I55862774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031643967","display_name":"Pratiti Ghosh","orcid":"https://orcid.org/0000-0002-9194-2882"},"institutions":[{"id":"https://openalex.org/I55862774","display_name":"West Bengal State University","ror":"https://ror.org/04qs5en05","country_code":"IN","type":"education","lineage":["https://openalex.org/I55862774"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pratiti Ghosh","raw_affiliation_strings":["West Bengal State University,Department of Physiology,Kolkata,India,700126"],"affiliations":[{"raw_affiliation_string":"West Bengal State University,Department of Physiology,Kolkata,India,700126","institution_ids":["https://openalex.org/I55862774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101235655"],"corresponding_institution_ids":["https://openalex.org/I55862774"],"apc_list":null,"apc_paid":null,"fwci":0.3108,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.65850321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8879395127296448},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5600982904434204},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5447020530700684},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5136086940765381},{"id":"https://openalex.org/keywords/distribution","display_name":"Distribution (mathematics)","score":0.5100999474525452},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4026278853416443},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.38933926820755005},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.37811189889907837},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2610747516155243},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.22489938139915466},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15808901190757751},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12939497828483582},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.07773113250732422}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8879395127296448},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5600982904434204},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5447020530700684},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5136086940765381},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.5100999474525452},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4026278853416443},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38933926820755005},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37811189889907837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2610747516155243},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22489938139915466},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15808901190757751},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12939497828483582},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.07773113250732422},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icccnt61001.2024.10723857","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/icccnt61001.2024.10723857","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 15th International Conference on Computing Communication and Networking Technologies (ICCCNT)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W2097706195","https://openalex.org/W2103467580","https://openalex.org/W2553563417","https://openalex.org/W3120848256","https://openalex.org/W4318957081","https://openalex.org/W4385286182","https://openalex.org/W4388468885","https://openalex.org/W4388937393","https://openalex.org/W4388950990","https://openalex.org/W4389682894","https://openalex.org/W4389777119","https://openalex.org/W4389777411","https://openalex.org/W4391329853","https://openalex.org/W4391936577","https://openalex.org/W4392544200","https://openalex.org/W4393146464","https://openalex.org/W4394577710","https://openalex.org/W4396712702","https://openalex.org/W4396949882","https://openalex.org/W4396949897","https://openalex.org/W4400232289","https://openalex.org/W4400232735","https://openalex.org/W4400233047","https://openalex.org/W6787937688","https://openalex.org/W6788754190","https://openalex.org/W6791976374","https://openalex.org/W6792431924","https://openalex.org/W6792635283","https://openalex.org/W6860690803"],"related_works":["https://openalex.org/W2003194288","https://openalex.org/W2513589746","https://openalex.org/W2153919606","https://openalex.org/W2213189664","https://openalex.org/W2074002899","https://openalex.org/W2062254828","https://openalex.org/W4237480606","https://openalex.org/W2936968863","https://openalex.org/W1971792277","https://openalex.org/W2084707189"],"abstract_inverted_index":{"Introduction:":[0],"P-glycoprotein,":[1],"an":[2],"integral":[3],"membrane":[4],"transporter,":[5,32],"is":[6,144],"a":[7,17,78],"critical":[8],"gatekeeper":[9],"in":[10],"the":[11,68,109],"absorption,":[12],"distribution":[13,140],"and":[14,22,43,59,135],"elimination":[15],"of":[16,20,25,36,64,81,138],"wide":[18],"range":[19],"drugs":[21],"xenobiotics.":[23],"Identification":[24],"natural":[26,52,82,93],"compounds":[27,53,83,94],"as":[28,56,104,124],"substrates":[29,58],"for":[30,84,99,113],"this":[31],"expands":[33],"our":[34],"understanding":[35],"their":[37,62,85,102,133],"potential":[38,86,136],"impact":[39],"on":[40],"drug":[41,139],"interactions":[42,134],"pharmacokinetics.":[44],"Objectives:":[45],"This":[46],"in-silico":[47],"study":[48,129],"aims":[49],"to":[50,60,76,146],"identify":[51],"from":[54],"spices":[55],"p-glycoprotein":[57,114,126],"investigate":[61],"possibility":[63],"being":[65],"effluxed":[66],"by":[67,116],"multidrug-resistant":[69],"transporter.":[70],"Methods:":[71],"Molecular":[72],"docking-simulations":[73],"are":[74],"employed":[75],"screen":[77],"diverse":[79],"library":[80],"interaction":[87],"with":[88,95],"p-glycoprotein.":[89],"Results:":[90],"Identified":[91],"several":[92],"high":[96],"binding":[97,111],"affinities":[98],"p-glycoprotein,":[100],"suggesting":[101],"potency":[103],"good":[105],"substrates.":[106,127],"Vitexin":[107,121],"showed":[108],"highest":[110],"affinity":[112],"followed":[115],"gamma-glutamyl-S-allyl":[117],"cysteine,":[118],"apigenin-7-O-glucoside.":[119],"Conclusion:":[120],"may":[122],"act":[123],"lead":[125],"The":[128],"provides":[130],"insights":[131],"into":[132],"alteration":[137],"patterns.":[141],"Further":[142],"research":[143],"needed":[145],"confirm":[147],"these":[148],"findings.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2025-12-22T23:10:17.713674","created_date":"2025-10-10T00:00:00"}
