{"id":"https://openalex.org/W4388937572","doi":"https://doi.org/10.1109/icccnt56998.2023.10307192","title":"Machine Learning-based Prediction of FGFR Kinase Inhibitors: A comparative study and implications for Targeted Cancer Treatment","display_name":"Machine Learning-based Prediction of FGFR Kinase Inhibitors: A comparative study and implications for Targeted Cancer Treatment","publication_year":2023,"publication_date":"2023-07-06","ids":{"openalex":"https://openalex.org/W4388937572","doi":"https://doi.org/10.1109/icccnt56998.2023.10307192"},"language":"en","primary_location":{"id":"doi:10.1109/icccnt56998.2023.10307192","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/icccnt56998.2023.10307192","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 14th International Conference on Computing Communication and Networking Technologies (ICCCNT)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102582627","display_name":"Md Adil","orcid":null},"institutions":[{"id":"https://openalex.org/I105094715","display_name":"National Institute of Technology Kurukshetra","ror":"https://ror.org/04909p852","country_code":"IN","type":"education","lineage":["https://openalex.org/I105094715"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Md Adil","raw_affiliation_strings":["National Institute of Technology Kurukshetra,Mechanical Engineering,Kurukshetra,India","Mechanical Engineering, National Institute of Technology Kurukshetra, Kurukshetra, India"],"affiliations":[{"raw_affiliation_string":"National Institute of Technology Kurukshetra,Mechanical Engineering,Kurukshetra,India","institution_ids":["https://openalex.org/I105094715"]},{"raw_affiliation_string":"Mechanical Engineering, National Institute of Technology Kurukshetra, Kurukshetra, India","institution_ids":["https://openalex.org/I105094715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093324118","display_name":"Ganesh Karnati","orcid":"https://orcid.org/0009-0009-8486-7667"},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ganesh Karnati","raw_affiliation_strings":["Manipal Institute of Technology,Department of Biotechnology,Manipal,India","Department of Biotechnology, Manipal Institute of Technology, Manipal, India"],"affiliations":[{"raw_affiliation_string":"Manipal Institute of Technology,Department of Biotechnology,Manipal,India","institution_ids":[]},{"raw_affiliation_string":"Department of Biotechnology, Manipal Institute of Technology, Manipal, India","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083631344","display_name":"Sujitha Duggimpudi","orcid":null},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sujitha D","raw_affiliation_strings":["Vellore Institute of Technology,School of Computer Science and Engineering,Chennai,India","School of Computer Science and Engineering, Vellore Institute of Technology, Chennai, India"],"affiliations":[{"raw_affiliation_string":"Vellore Institute of Technology,School of Computer Science and Engineering,Chennai,India","institution_ids":["https://openalex.org/I876193797"]},{"raw_affiliation_string":"School of Computer Science and Engineering, Vellore Institute of Technology, Chennai, India","institution_ids":["https://openalex.org/I876193797"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102582627"],"corresponding_institution_ids":["https://openalex.org/I105094715"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31765677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"Fibroblast growth factor receptor","score":0.8307977318763733},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.597025454044342},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5342416167259216},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.485058456659317},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.4679141640663147},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.4616023898124695},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"Targeted therapy","score":0.4518470764160156},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4112071692943573},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.39929866790771484},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3936055898666382},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.388934850692749},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36276131868362427},{"id":"https://openalex.org/keywords/fibroblast-growth-factor","display_name":"Fibroblast growth factor","score":0.33869266510009766},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31317317485809326},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.31146347522735596},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.28527164459228516},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.2618948221206665},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1973385214805603}],"concepts":[{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.8307977318763733},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.597025454044342},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5342416167259216},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.485058456659317},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.4679141640663147},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4616023898124695},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4518470764160156},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4112071692943573},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39929866790771484},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3936055898666382},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.388934850692749},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36276131868362427},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.33869266510009766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31317317485809326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31146347522735596},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28527164459228516},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2618948221206665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1973385214805603}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icccnt56998.2023.10307192","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/icccnt56998.2023.10307192","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 14th International Conference on Computing Communication and Networking Technologies (ICCCNT)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1981976602","https://openalex.org/W2043509228","https://openalex.org/W2048697945","https://openalex.org/W2106605095","https://openalex.org/W2113364934","https://openalex.org/W2135732933","https://openalex.org/W2414345145","https://openalex.org/W2536120357","https://openalex.org/W2556014018","https://openalex.org/W2735467165","https://openalex.org/W2774836366","https://openalex.org/W2810711993","https://openalex.org/W2900090807","https://openalex.org/W2906484232","https://openalex.org/W2940819419","https://openalex.org/W2950977943","https://openalex.org/W3082979654","https://openalex.org/W3098996042","https://openalex.org/W3115918303","https://openalex.org/W3157976194","https://openalex.org/W3167001840","https://openalex.org/W4210617107","https://openalex.org/W4221084257"],"related_works":["https://openalex.org/W4243851374","https://openalex.org/W2075500765","https://openalex.org/W2017952250","https://openalex.org/W1981099772","https://openalex.org/W4385199358","https://openalex.org/W21291533","https://openalex.org/W2358034211","https://openalex.org/W2098466520","https://openalex.org/W2004632928","https://openalex.org/W3148235309"],"abstract_inverted_index":{"Fibroblast":[0],"Growth":[1,48],"Factor":[2],"receptor":[3,54],"alterations":[4,25],"are":[5],"particularly":[6],"prevalent":[7],"in":[8,43,59],"certain":[9],"cancer":[10,41],"types,":[11],"such":[12],"as":[13,29],"breast":[14],"cancer,":[15,17],"lung":[16],"and":[18,78,105],"cholangiocarcinoma.":[19],"In":[20,62],"some":[21],"cases,":[22],"specific":[23],"FGFR":[24,32],"have":[26],"been":[27],"identified":[28],"therapeutic":[30],"targets.":[31],"kinase":[33],"inhibitors":[34],"poses":[35],"a":[36,56],"promising":[37],"role":[38],"for":[39],"targeted":[40],"therapy":[42],"patients":[44],"with":[45],"Fibro":[46],"Blast":[47],"Receptor":[49],"alterations,":[50],"predicting":[51],"ligands":[52],"inhibiting":[53],"is":[55],"crucial":[57],"task":[58],"drug":[60],"discovery.":[61],"this":[63],"study":[64],"we":[65],"present":[66],"different":[67,109],"Machine":[68,88],"Learning":[69,89],"techniques":[70],"to":[71,79,108],"screen":[72],"the":[73,81,95],"compounds":[74],"along":[75],"various":[76],"databases":[77],"predict":[80],"pIC50":[82],"values":[83],"based":[84],"on":[85],"highly":[86],"performed":[87],"technique.":[90],"The":[91],"studies":[92],"reveal":[93],"that":[94],"usage":[96],"of":[97],"Random":[98],"Forest":[99],"gives":[100],"best":[101],"yield":[102],"over":[103],"classification":[104],"regression":[106],"compared":[107],"techniques.":[110]},"counts_by_year":[],"updated_date":"2025-12-21T01:58:51.020947","created_date":"2025-10-10T00:00:00"}
