{"id":"https://openalex.org/W4200325524","doi":"https://doi.org/10.1109/iccad52417.2021.9638732","title":"Outlining the Landscape of Personalized Lung Cancer Treatment in the Era of Cyber-Physical Systems","display_name":"Outlining the Landscape of Personalized Lung Cancer Treatment in the Era of Cyber-Physical Systems","publication_year":2021,"publication_date":"2021-11-03","ids":{"openalex":"https://openalex.org/W4200325524","doi":"https://doi.org/10.1109/iccad52417.2021.9638732"},"language":"en","primary_location":{"id":"doi:10.1109/iccad52417.2021.9638732","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iccad52417.2021.9638732","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 International Conference on Control, Automation and Diagnosis (ICCAD)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017591069","display_name":"Maria Ghita","orcid":"https://orcid.org/0000-0002-3463-5173"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210116480","display_name":"Flanders Make (Belgium)","ror":"https://ror.org/02ndjfz59","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210116480"]},{"id":"https://openalex.org/I4210118715","display_name":"Cancer Research Institute Ghent","ror":"https://ror.org/02afm7029","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210118715"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maria Ghita","raw_affiliation_strings":["Cancer Research Institute Ghent, Ghent, Belgium","EEDT core lab on Decision and Control, Flanders Make consortium, Ghent, Belgium","Research group of Dynamical Systems and Control, Ghent University, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute Ghent, Ghent, Belgium","institution_ids":["https://openalex.org/I4210118715"]},{"raw_affiliation_string":"EEDT core lab on Decision and Control, Flanders Make consortium, Ghent, Belgium","institution_ids":["https://openalex.org/I4210116480"]},{"raw_affiliation_string":"Research group of Dynamical Systems and Control, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073964670","display_name":"Dana Copo\u0163","orcid":"https://orcid.org/0000-0002-6010-830X"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210116480","display_name":"Flanders Make (Belgium)","ror":"https://ror.org/02ndjfz59","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210116480"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dana Copot","raw_affiliation_strings":["EEDT core lab on Decision and Control, Flanders Make consortium, Ghent, Belgium","Research group of Dynamical Systems and Control, Ghent University, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EEDT core lab on Decision and Control, Flanders Make consortium, Ghent, Belgium","institution_ids":["https://openalex.org/I4210116480"]},{"raw_affiliation_string":"Research group of Dynamical Systems and Control, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089177738","display_name":"Dirk Verellen","orcid":"https://orcid.org/0000-0002-0734-6464"},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]},{"id":"https://openalex.org/I4210136049","display_name":"Iridium Kankernetwerk","ror":"https://ror.org/04hewny41","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210136049"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dirk Verellen","raw_affiliation_strings":["Department of Radiation Oncology, Iridium Cancer Network \u2013 GZA Hospitals Sint Augustinus, Wilrijk, Belgium","Department of Radiotherapy, Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Iridium Cancer Network \u2013 GZA Hospitals Sint Augustinus, Wilrijk, Belgium","institution_ids":["https://openalex.org/I4210136049"]},{"raw_affiliation_string":"Department of Radiotherapy, Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004573956","display_name":"Clara M. Ionescu","orcid":"https://orcid.org/0000-0001-7685-035X"},"institutions":[{"id":"https://openalex.org/I158333966","display_name":"Technical University of Cluj-Napoca","ror":"https://ror.org/03r8nwp71","country_code":"RO","type":"education","lineage":["https://openalex.org/I158333966"]},{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210116480","display_name":"Flanders Make (Belgium)","ror":"https://ror.org/02ndjfz59","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210116480"]}],"countries":["BE","RO"],"is_corresponding":false,"raw_author_name":"Clara Mihaela Ionescu","raw_affiliation_strings":["Department of Automatic Control, Technical University of Cluj Napoca, Cluj, Romania","EEDT core lab on Decision and Control, Flanders Make consortium, Ghent, Belgium","Research group of Dynamical Systems and Control, Ghent University, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Automatic Control, Technical University of Cluj Napoca, Cluj, Romania","institution_ids":["https://openalex.org/I158333966"]},{"raw_affiliation_string":"EEDT core lab on Decision and Control, Flanders Make consortium, Ghent, Belgium","institution_ids":["https://openalex.org/I4210116480"]},{"raw_affiliation_string":"Research group of Dynamical Systems and Control, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.7648332715034485},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.6653281450271606},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.559408962726593},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.5290229320526123},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.48584482073783875},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.47250473499298096},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.45307019352912903},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.4389329254627228},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.43273210525512695},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.42262890934944153},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3929693102836609},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.3918396830558777},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.30685657262802124},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.26316899061203003},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.19161999225616455},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.191572904586792},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.17800477147102356},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15409696102142334}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7648332715034485},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6653281450271606},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.559408962726593},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.5290229320526123},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.48584482073783875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47250473499298096},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45307019352912903},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4389329254627228},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.43273210525512695},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.42262890934944153},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3929693102836609},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3918396830558777},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30685657262802124},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.26316899061203003},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19161999225616455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.191572904586792},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17800477147102356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15409696102142334}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iccad52417.2021.9638732","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iccad52417.2021.9638732","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 International Conference on Control, Automation and Diagnosis (ICCAD)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1529490909","https://openalex.org/W1811738687","https://openalex.org/W2008227309","https://openalex.org/W2011070470","https://openalex.org/W2040666633","https://openalex.org/W2061667995","https://openalex.org/W2107538705","https://openalex.org/W2126595086","https://openalex.org/W2149142749","https://openalex.org/W2153169173","https://openalex.org/W2471850952","https://openalex.org/W2484450783","https://openalex.org/W2528861955","https://openalex.org/W2560067205","https://openalex.org/W2603614325","https://openalex.org/W2618567494","https://openalex.org/W2618902321","https://openalex.org/W2759355813","https://openalex.org/W2768806839","https://openalex.org/W2792705209","https://openalex.org/W2807497391","https://openalex.org/W2811418893","https://openalex.org/W2847081133","https://openalex.org/W2891532865","https://openalex.org/W2990372525","https://openalex.org/W2998072527","https://openalex.org/W3008913290","https://openalex.org/W3015401256","https://openalex.org/W3031211271","https://openalex.org/W3033449782","https://openalex.org/W3034320022","https://openalex.org/W3119620423","https://openalex.org/W3154820809","https://openalex.org/W4236883743","https://openalex.org/W6638360052","https://openalex.org/W6678566556"],"related_works":["https://openalex.org/W3082935376","https://openalex.org/W4399651953","https://openalex.org/W4386960999","https://openalex.org/W2899657781","https://openalex.org/W4322484660","https://openalex.org/W3193951088","https://openalex.org/W4388011470","https://openalex.org/W4230423494","https://openalex.org/W4298001029","https://openalex.org/W4393252403"],"abstract_inverted_index":{"Lung":[0],"cancer":[1],"treatment":[2,97,128],"management":[3],"has":[4],"always":[5],"been":[6],"at":[7],"the":[8,21,91,113,124,127],"interface":[9],"of":[10,23,45,57,63,80,93,115,126,137],"medicine,":[11],"biology,":[12],"and":[13,49,61,71,83,104,118,141],"physics.":[14],"Rapid":[15],"progress":[16,89],"is":[17],"being":[18],"made":[19],"in":[20,90,129],"direction":[22],"new":[24],"high-precision":[25],"technology":[26],"developments":[27],"that":[28],"emerge":[29],"toward":[30],"more":[31],"patient-":[32],"specific":[33,59],"therapies":[34],"with":[35,77,109,146],"lower":[36],"toxicity.":[37],"This":[38],"paper":[39],"provides":[40],"a":[41,54,147],"complete":[42],"generic":[43],"framework":[44],"lung":[46,142],"tumor":[47,81,139],"targeting":[48],"patient":[50],"individualization,":[51],"thereby":[52],"allowing":[53],"rational":[55],"choice":[56],"tumor-":[58],"dose":[60],"type":[62],"treatment.":[64],"Possible":[65],"comprehensive":[66],"strategies":[67],"including":[68],"radiotherapy,":[69],"immunotherapy,":[70],"targeted":[72],"therapy":[73,100],"drug":[74],"(antiangiogenic),":[75],"coupled":[76],"mathematical":[78],"modeling":[79],"dynamics":[82],"respiratory":[84],"mechanics":[85],"would":[86],"bring":[87],"considerable":[88],"area":[92],"prediction":[94],"models":[95],"for":[96],"outcomes.":[98],"The":[99],"becomes":[101],"model-based":[102],"predicted":[103],"leads":[105],"to":[106,134],"personalized":[107],"radiotherapy":[108],"optimal":[110],"doses,":[111],"decreasing":[112],"risks":[114],"normal-tissue":[116],"effects":[117],"costs":[119],"as":[120],"well.":[121],"To":[122],"maximize":[123],"success":[125],"an":[130],"individual,":[131],"clinicians":[132],"need":[133],"be":[135],"aware":[136],"both":[138],"characteristics":[140],"tissue":[143],"properties":[144],"(assessed":[145],"forced":[148],"oscillation":[149],"technique":[150],"device).":[151]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
