{"id":"https://openalex.org/W2566245499","doi":"https://doi.org/10.1109/iccabs.2016.7802788","title":"Are circulating type 2 Vaccine-Derived Polioviruses (VDPVs) genetically distinguishable from immunodeficiency-associated VDPVs?","display_name":"Are circulating type 2 Vaccine-Derived Polioviruses (VDPVs) genetically distinguishable from immunodeficiency-associated VDPVs?","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2566245499","doi":"https://doi.org/10.1109/iccabs.2016.7802788","mag":"2566245499"},"language":"en","primary_location":{"id":"doi:10.1109/iccabs.2016.7802788","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iccabs.2016.7802788","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 6th International Conference on Computational Advances in Bio and Medical Sciences (ICCABS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011517981","display_name":"Kun Zhao","orcid":"https://orcid.org/0000-0002-4479-1102"},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"funder","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kun Zhao","raw_affiliation_strings":["Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA"],"affiliations":[{"raw_affiliation_string":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA","institution_ids":["https://openalex.org/I19085752","https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040889902","display_name":"Jaume Jorba","orcid":"https://orcid.org/0000-0001-6552-9878"},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"funder","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaume Jorba","raw_affiliation_strings":["Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA"],"affiliations":[{"raw_affiliation_string":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA","institution_ids":["https://openalex.org/I19085752","https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091054823","display_name":"Jane Iber","orcid":null},"institutions":[{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]},{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"funder","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane Iber","raw_affiliation_strings":["Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA"],"affiliations":[{"raw_affiliation_string":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA","institution_ids":["https://openalex.org/I19085752","https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340176","display_name":"Qi Chen","orcid":"https://orcid.org/0000-0002-6190-0403"},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"funder","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Chen","raw_affiliation_strings":["Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA"],"affiliations":[{"raw_affiliation_string":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA","institution_ids":["https://openalex.org/I19085752","https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110460094","display_name":"Jing Shaw","orcid":null},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"funder","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Shaw","raw_affiliation_strings":["Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA"],"affiliations":[{"raw_affiliation_string":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA","institution_ids":["https://openalex.org/I19085752","https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005278173","display_name":"Kelley Bullard","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelley Bullard","raw_affiliation_strings":["IHRC Inc. Atlanta, Georgia 30333, USA"],"affiliations":[{"raw_affiliation_string":"IHRC Inc. Atlanta, Georgia 30333, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049818122","display_name":"Olen M. Kew","orcid":null},"institutions":[{"id":"https://openalex.org/I4210128914","display_name":"The Task Force for Global Health","ror":"https://ror.org/03747hz63","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210128914"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olen Kew","raw_affiliation_strings":["Task Force for Global Health, Decatur, Georgia 30030, USA"],"affiliations":[{"raw_affiliation_string":"Task Force for Global Health, Decatur, Georgia 30030, USA","institution_ids":["https://openalex.org/I4210128914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040640521","display_name":"Cara C. Burns","orcid":"https://orcid.org/0000-0003-2582-2476"},"institutions":[{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]},{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"funder","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cara Burns","raw_affiliation_strings":["Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA"],"affiliations":[{"raw_affiliation_string":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA","institution_ids":["https://openalex.org/I19085752","https://openalex.org/I1289490764"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5011517981"],"corresponding_institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I19085752"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.23030806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.7461599111557007},{"id":"https://openalex.org/keywords/poliovirus","display_name":"Poliovirus","score":0.6741148233413696},{"id":"https://openalex.org/keywords/genbank","display_name":"GenBank","score":0.6598002314567566},{"id":"https://openalex.org/keywords/outbreak","display_name":"Outbreak","score":0.6205270886421204},{"id":"https://openalex.org/keywords/vaccination","display_name":"Vaccination","score":0.5008234977722168},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4965875744819641},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4607928395271301},{"id":"https://openalex.org/keywords/capsid","display_name":"Capsid","score":0.43188321590423584},{"id":"https://openalex.org/keywords/transmission","display_name":"Transmission (telecommunications)","score":0.41090357303619385},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.24140065908432007},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13973158597946167},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.13193470239639282}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7461599111557007},{"id":"https://openalex.org/C2779631682","wikidata":"https://www.wikidata.org/wiki/Q12438936","display_name":"Poliovirus","level":3,"score":0.6741148233413696},{"id":"https://openalex.org/C79029880","wikidata":"https://www.wikidata.org/wiki/Q901755","display_name":"GenBank","level":3,"score":0.6598002314567566},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.6205270886421204},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5008234977722168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4965875744819641},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4607928395271301},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.43188321590423584},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.41090357303619385},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.24140065908432007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13973158597946167},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13193470239639282},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iccabs.2016.7802788","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iccabs.2016.7802788","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE 6th International Conference on Computational Advances in Bio and Medical Sciences (ICCABS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6600000262260437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401246297","https://openalex.org/W2137572138","https://openalex.org/W4316495397","https://openalex.org/W2968050865","https://openalex.org/W2977306144","https://openalex.org/W2076921277","https://openalex.org/W2399594384","https://openalex.org/W2124717482","https://openalex.org/W2123147754","https://openalex.org/W2184832223"],"abstract_inverted_index":{"Vaccine-Derived":[0],"Polioviruses":[1],"(VDPVs)":[2],"may":[3,287],"emerge":[4],"during":[5,12,37,305],"person-to-person":[6,306],"transmission":[7,307],"(circulating":[8],"VDPV":[9,36,88],"[cVDPV])":[10],"or":[11,94],"prolonged":[13],"replication":[14],"in":[15,67,103,230,272,312],"individuals":[16],"with":[17,267,309],"primary":[18],"immunodeficiency":[19],"(iVDPV).":[20],"To":[21],"prevent":[22],"the":[23,35,38,72,85,97,104,161,194,244,249,280,290,293,302,320,329,340,348],"emergence":[24],"of":[25,34,74,154,160,196,224,252,292,325],"type":[26],"2":[27,189],"vaccine-derived":[28],"polioviruses":[29],"(VDPV2s)":[30],"which":[31],"represents":[32],">90%":[33],"past":[39],"two":[40,105,245],"years,":[41],"WHO":[42],"implemented":[43],"a":[44,75,109,152,240],"worldwide":[45],"synchronized":[46],"switch":[47],"from":[48,167,335],"trivalent":[49],"oral":[50],"poliovirus":[51,144,336],"vaccine":[52],"(tOPV;":[53],"types":[54,63],"1,":[55],"2,":[56],"and":[57,65,120,132,156,176,200,206,214,219,227,235,254,259,285,299,301,327,353],"3)":[58,66],"to":[59,82,91,141,186,192,346],"bivalent":[60],"OPV":[61],"(bOPV;":[62],"1":[64],"April":[68],"2016.":[69],"When":[70],"planning":[71],"scope":[73],"post-switch":[76],"outbreak":[77,107,145],"response,":[78,146],"it":[79],"is":[80,89,322,339],"important":[81],"know":[83],"if":[84],"recently":[86],"identified":[87],"likely":[90],"be":[92,136,288],"cVDPV":[93,131,155],"iVDPV,":[95],"as":[96],"public":[98],"health":[99],"responses":[100],"dramatically":[101],"differ":[102],"events:":[106],"requires":[108,116],"community":[110],"immunization":[111],"response":[112],"while":[113],"chronic":[114,310],"infection":[115],"careful":[117],"patient":[118],"monitoring":[119],"potential":[121],"individual":[122],"treatment.":[123],"Here":[124],"we":[125],"demonstrate":[126],"that":[127,279],"genetic":[128,197,281,349],"distinctions":[129],"between":[130,233,243,283,297,351],"iVDPV":[133,157],"sequences":[134,159,208],"can":[135],"calculated":[137],"(to":[138],"some":[139],"extent)":[140],"inform":[142],"global":[143],"particularly":[147],"for":[148,212,239,331],"VDPV2.":[149],"We":[150,182],"performed":[151],"survey":[153],"nucleotide":[158,198],"VP1":[162,258],"capsid":[163],"region":[164],"(\u223c900":[165],"nucleotides)":[166],"GenBank.":[168],"A":[169],"non-redundant":[170],"dataset":[171,316],"contains":[172],"33":[173,177],"cVDPV2":[174,205,234],"isolates":[175,179],"iVDPV2":[178,207,236,273],"was":[180,317],"built.":[181],"compared":[183,308],"each":[184],"sequence":[185],"its":[187],"Sabin":[188],"parental":[190],"strain":[191],"determine":[193],"number":[195],"(NT)":[199],"amino":[201],"acid":[202],"(AA)":[203],"substitutions.":[204],"show":[209],"similar":[210],"profiles":[211],"NT":[213,253],"AA":[215,220,255],"frequencies,":[216],"codon":[217,228],"usage,":[218],"conservation.":[221],"Simple":[222],"counts":[223],"NT,":[225],"AA,":[226],"substitutions":[229,256],"comparative":[231],"analyses":[232],"were":[237,264],"insufficient":[238],"clear":[241],"distinction":[242],"VDPV2":[246],"categories.":[247],"However,":[248],"combined":[250],"measures":[251],"(from":[257],"neutralizing":[260],"antigenic":[261],"site":[262],"sequences)":[263],"more":[265,268],"informative,":[266],"non-synonymous":[269],"(AA":[270],"changes)":[271],"than":[274],"cVDPV2.":[275],"This":[276,338],"work":[277],"highlights":[278],"variations":[282],"iVDPVs":[284],"cVDPVs":[286,352],"reflect":[289],"differences":[291],"viral":[294],"micro-environments,":[295],"interactions":[296],"virus":[298],"host,":[300],"selective":[303],"pressures":[304],"infections":[311],"immune-deficient":[313],"patients.":[314],"The":[315],"small":[318],"but":[319],"issue":[321],"certainly":[323],"deserving":[324],"attentions":[326],"suggesting":[328],"needs":[330],"further":[332],"data":[333],"collections":[334],"surveillance.":[337],"first":[341],"attempt":[342],"using":[343],"computational":[344],"techniques":[345],"quantify":[347],"difference":[350],"iVDPVs.":[354]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
