{"id":"https://openalex.org/W1969776391","doi":"https://doi.org/10.1109/iccabs.2014.6863922","title":"A systems biology analysis for the whole genome sequencing data","display_name":"A systems biology analysis for the whole genome sequencing data","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W1969776391","doi":"https://doi.org/10.1109/iccabs.2014.6863922","mag":"1969776391"},"language":"en","primary_location":{"id":"doi:10.1109/iccabs.2014.6863922","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iccabs.2014.6863922","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE 4th International Conference on Computational Advances in Bio and Medical Sciences (ICCABS)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085530690","display_name":"Deepali Jhamb","orcid":null},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepali Jhamb","raw_affiliation_strings":["School of Informatics and Computing, Indiana University Purdue University Indianapolis, Indiana, USA","School of Informatics and Computing, Indiana University --- Purdue University, Indianapolis, USA 46202#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Informatics and Computing, Indiana University Purdue University Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"School of Informatics and Computing, Indiana University --- Purdue University, Indianapolis, USA 46202#TAB#","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029457488","display_name":"Meeta Pradhan","orcid":"https://orcid.org/0000-0003-4450-1897"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meeta P. Pradhan","raw_affiliation_strings":["School of Informatics and Computing, Indiana University Purdue University Indianapolis, Indiana, USA","School of Informatics and Computing, Indiana University --- Purdue University, Indianapolis, USA 46202#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Informatics and Computing, Indiana University Purdue University Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"School of Informatics and Computing, Indiana University --- Purdue University, Indianapolis, USA 46202#TAB#","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061266467","display_name":"Akshay Desai","orcid":null},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akshay Desai","raw_affiliation_strings":["School of Informatics and Computing, Indiana University Purdue University Indianapolis, Indiana, USA","School of Informatics and Computing, Indiana University --- Purdue University, Indianapolis, USA 46202#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Informatics and Computing, Indiana University Purdue University Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"School of Informatics and Computing, Indiana University --- Purdue University, Indianapolis, USA 46202#TAB#","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044460012","display_name":"Mathew Palakal","orcid":"https://orcid.org/0000-0002-2990-0999"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mathew J. Palakal","raw_affiliation_strings":["School of Informatics and Computing, Indiana University Purdue University Indianapolis, Indiana, USA","School of Informatics and Computing, Indiana University --- Purdue University, Indianapolis, USA 46202#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Informatics and Computing, Indiana University Purdue University Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"School of Informatics and Computing, Indiana University --- Purdue University, Indianapolis, USA 46202#TAB#","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013136525","display_name":"Premkumar Duraiswamy","orcid":null},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Premkumar Duraiswamy","raw_affiliation_strings":["Department of Computer Science and Engineering, Indiana University Purdue University Indianapolis, Indiana, USA","[Department of Computer Science and Engineering, Indiana University Purdue University Indianapolis, USA 46202]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Indiana University Purdue University Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"[Department of Computer Science and Engineering, Indiana University Purdue University Indianapolis, USA 46202]","institution_ids":["https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55769427"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6869984865188599},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6698153018951416},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.6077545881271362},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.584173858165741},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5739659667015076},{"id":"https://openalex.org/keywords/cancer-genome-sequencing","display_name":"Cancer genome sequencing","score":0.5170203447341919},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.4704424738883972},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.44835880398750305},{"id":"https://openalex.org/keywords/whole-genome-sequencing","display_name":"Whole genome sequencing","score":0.44292402267456055},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.4180014133453369},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35621482133865356},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3384588360786438},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1726711094379425}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6869984865188599},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6698153018951416},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.6077545881271362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.584173858165741},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5739659667015076},{"id":"https://openalex.org/C205270622","wikidata":"https://www.wikidata.org/wiki/Q17082639","display_name":"Cancer genome sequencing","level":5,"score":0.5170203447341919},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.4704424738883972},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.44835880398750305},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.44292402267456055},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4180014133453369},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35621482133865356},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3384588360786438},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1726711094379425},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iccabs.2014.6863922","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iccabs.2014.6863922","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE 4th International Conference on Computational Advances in Bio and Medical Sciences (ICCABS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1523536597","https://openalex.org/W1823837540","https://openalex.org/W1966327575","https://openalex.org/W1966378425","https://openalex.org/W1966923535","https://openalex.org/W1976719696","https://openalex.org/W1991281695","https://openalex.org/W1995716639","https://openalex.org/W2009696139","https://openalex.org/W2018581767","https://openalex.org/W2054051862","https://openalex.org/W2059390311","https://openalex.org/W2083479872","https://openalex.org/W2085005232","https://openalex.org/W2096791516","https://openalex.org/W2100731712","https://openalex.org/W2101983393","https://openalex.org/W2103017472","https://openalex.org/W2106578986","https://openalex.org/W2117301047","https://openalex.org/W2118268786","https://openalex.org/W2121169582","https://openalex.org/W2122683221","https://openalex.org/W2128016314","https://openalex.org/W2130775883","https://openalex.org/W2130988047","https://openalex.org/W2136287174","https://openalex.org/W2148715978","https://openalex.org/W2161556727","https://openalex.org/W2163485494","https://openalex.org/W2259938310","https://openalex.org/W4249273120","https://openalex.org/W6631384600","https://openalex.org/W6642178298","https://openalex.org/W6649403215"],"related_works":["https://openalex.org/W24843447","https://openalex.org/W94193318","https://openalex.org/W2073808674","https://openalex.org/W322176015","https://openalex.org/W2028140658","https://openalex.org/W2173289516","https://openalex.org/W2037306065","https://openalex.org/W2062993691","https://openalex.org/W2115386182","https://openalex.org/W1825953629"],"abstract_inverted_index":{"The":[0],"next":[1],"generation":[2],"sequencing":[3,47],"technology":[4],"has":[5],"enabled":[6],"the":[7,10,34,38,44,56,62,69,76,81,92],"understanding":[8],"of":[9,13,37,58,75,94],"whole":[11,45],"genome":[12,46],"an":[14],"organism":[15],"at":[16],"a":[17,28,53,89],"greater":[18],"coverage":[19],"and":[20,84,87,102],"reduced":[21],"cost.":[22],"In":[23],"this":[24],"study,":[25],"we":[26],"provide":[27],"systems":[29],"biology":[30],"approach":[31,50],"to":[32,97],"understand":[33],"functional":[35,73],"relevance":[36],"single":[39],"nucleotide":[40],"variants":[41,101],"identified":[42],"by":[43],"studies.":[48],"This":[49],"also":[51],"includes":[52],"methodology":[54],"for":[55,80,91],"identification":[57],"conserved":[59],"modules":[60],"among":[61],"family":[63],"members.":[64],"Our":[65],"study":[66],"contributes":[67],"towards":[68],"much":[70],"needed":[71],"downstream":[72],"analysis":[74,93],"variant":[77],"data,":[78],"especially":[79],"low":[82],"frequency":[83],"novel":[85],"variants,":[86],"provides":[88],"framework":[90],"multiple":[95],"genomes":[96],"derive":[98],"relations":[99],"between":[100],"diseases.":[103]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
