{"id":"https://openalex.org/W2039831882","doi":"https://doi.org/10.1109/iccabs.2012.6182622","title":"Invited: A protein domain-centric approach to translational bioinformatics","display_name":"Invited: A protein domain-centric approach to translational bioinformatics","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W2039831882","doi":"https://doi.org/10.1109/iccabs.2012.6182622","mag":"2039831882"},"language":"en","primary_location":{"id":"doi:10.1109/iccabs.2012.6182622","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iccabs.2012.6182622","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 2nd International Conference on Computational Advances in Bio and medical Sciences (ICCABS)","raw_type":"proceedings-article"},"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013292761","display_name":"Maricel G. Kann","orcid":"https://orcid.org/0000-0003-0116-3883"},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maricel G. Kann","raw_affiliation_strings":["Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, USA","Dept of Biological Sciences, Univ. of Maryland, Baltimore County, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, USA","institution_ids":["https://openalex.org/I79272384"]},{"raw_affiliation_string":"Dept of Biological Sciences, Univ. of Maryland, Baltimore County, Baltimore, USA","institution_ids":["https://openalex.org/I79272384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013292761"],"corresponding_institution_ids":["https://openalex.org/I79272384"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9567000269889832,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9431999921798706,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/translational-bioinformatics","display_name":"Translational bioinformatics","score":0.7115297317504883},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5848416090011597},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5363840460777283},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.5163434743881226},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.490375280380249},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4776943027973175},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.45304301381111145},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.440967857837677},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.43460798263549805},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4221002757549286},{"id":"https://openalex.org/keywords/omim-online-mendelian-inheritance-in-man","display_name":"OMIM : Online Mendelian Inheritance in Man","score":0.4170836806297302},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3221660256385803},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.30101120471954346},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.298404335975647},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.23651662468910217},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.18441611528396606},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.1403815746307373},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.1204979419708252}],"concepts":[{"id":"https://openalex.org/C163293594","wikidata":"https://www.wikidata.org/wiki/Q7834541","display_name":"Translational bioinformatics","level":5,"score":0.7115297317504883},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5848416090011597},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5363840460777283},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.5163434743881226},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.490375280380249},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4776943027973175},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.45304301381111145},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.440967857837677},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43460798263549805},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4221002757549286},{"id":"https://openalex.org/C191791410","wikidata":"https://www.wikidata.org/wiki/Q241953","display_name":"OMIM : Online Mendelian Inheritance in Man","level":4,"score":0.4170836806297302},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3221660256385803},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30101120471954346},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.298404335975647},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.23651662468910217},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.18441611528396606},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1403815746307373},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.1204979419708252},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iccabs.2012.6182622","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iccabs.2012.6182622","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 2nd International Conference on Computational Advances in Bio and medical Sciences (ICCABS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4250615304","https://openalex.org/W2119412782","https://openalex.org/W4248234957","https://openalex.org/W562794435","https://openalex.org/W2068608913","https://openalex.org/W1994127362","https://openalex.org/W2720897370","https://openalex.org/W3124914020","https://openalex.org/W4232204725","https://openalex.org/W2479304738"],"abstract_inverted_index":{"Identifying":[0],"the":[1,56,60,152,159,171,200,211,222,239,285,304,308,318,343,350,369,373,379,403,410,415,429,451],"functional":[2,57,73,461],"context":[3,58],"for":[4,37,86,460],"key":[5],"molecular":[6,127,223,236],"disruptions":[7],"in":[8,97,180,368,434],"complex":[9],"diseases":[10,133],"is":[11,317,353],"a":[12,84,93,112,149,218,234,261,288],"major":[13],"goal":[14],"of":[15,41,59,89,161,203,213,225,238,256,264,268,287,307,320,345,375,384,392,428,431,442,444,463],"modern":[16],"medicine":[17],"that":[18,134,274,342,389],"will":[19],"lead":[20],"to":[21,122,157,173,194,196,207,216,229,249,279,290,302,327,355,378,402,439,453],"improved":[22],"preventive":[23],"clinical":[24,204],"approaches,":[25],"earlier":[26],"diagnosis":[27],"and":[28,39,48,176,184,242,245,283,437,465],"more":[29],"effective":[30],"personalized":[31],"disease":[32,42,90,100,162],"therapies.":[33],"Most":[34],"available":[35],"resources":[36],"visualization":[38,143],"analysis":[40,47],"mutations":[43,119,130,322,433],"centered":[44],"on":[45,55,165,396],"gene":[46],"do":[49],"not":[50,79,136],"leverage":[51],"information":[52],"about":[53,221],"similarity":[54,265],"mutation.":[61],"In":[62],"addition,":[63],"gene-centric":[64,142],"approaches":[65],"are":[66,120,277],"confounded":[67],"because":[68],"genes":[69,185],"may":[70],"share":[71],"some":[72,421],"sub-units,":[74],"or":[75],"protein":[76,94,107,123,166,240,292,435],"domains,":[77],"but":[78],"others.":[80],"We":[81,145,362,387],"have":[82,137,146,363,450],"built":[83],"resource":[85],"domain":[87,95,108,153,178,417],"mapping":[88],"mutations,":[91],"DMDM,":[92],"database":[96],"which":[98],"each":[99],"mutation":[101,163],"can":[102],"be":[103,208,454],"displayed":[104],"by":[105,125,210,349,371],"its":[106],"location.":[109],"DMDM":[110],"provides":[111],"unique":[113],"domain-level":[114],"view":[115,237],"where":[116],"human":[117,174,467],"coding":[118],"mapped":[121],"domains":[124,202],"highlighting":[126],"relationships":[128],"among":[129],"from":[131,469],"different":[132],"might":[135],"been":[138,299,335,340],"discovered":[139],"with":[140,187],"traditional":[141],"tools.":[144],"also":[147],"developed":[148],"statistical":[150],"method,":[151],"significance":[154,160],"scores":[155],"(DSScores),":[156],"assess":[158],"clusters":[164],"domains.":[167,386],"When":[168],"we":[169],"applied":[170],"DS-Scores":[172],"data":[175],"identified":[177],"hotspots":[179],"oncogenes,":[181],"tumor":[182],"suppressors,":[183],"associated":[186],"Mendelian":[188],"diseases.":[189],"Since":[190],"most":[191],"proteins":[192,258,276,394],"need":[193],"interact":[195],"perform":[197],"their":[198],"function,":[199],"identification":[201,212],"relevance":[205],"needs":[206],"complemented":[209],"domain-domain":[214,231],"interactions":[215,232,241,293],"provide":[217,233,426],"better":[219],"understanding":[220,441],"underpinning":[224],"disease.":[226],"Computational":[227],"tools":[228,459],"predict":[230,291],"detailed":[235],"complements":[243],"expensive":[244],"laborious":[246],"experimental":[247],"techniques":[248],"identify":[250,303],"such":[251],"interactions.":[252],"The":[253],"evolutionary":[254,281,312,382],"distances":[255],"interacting":[257,275,385,393,445],"often":[259],"display":[260],"higher":[262,398],"level":[263],"than":[266],"those":[267],"non-interacting":[269],"proteins.":[270,446],"This":[271,331],"finding":[272],"indicates":[273],"subject":[278],"common":[280,466],"constraints":[282],"constitute":[284],"basis":[286],"method":[289,352],"known":[294],"as":[295],"mirrortree.":[296],"It":[297,338],"has":[298,334,339],"difficult,":[300],"however,":[301,333],"direct":[305],"cause":[306],"observed":[309],"similarities":[310],"between":[311,323,359,381],"trees.":[313],"One":[314],"possible":[315],"explanation":[316],"existence":[319],"compensatory":[321,432],"partners":[324],"binding":[325,360,376,390,406,411],"sites":[326,377],"maintain":[328],"proper":[329],"binding.":[330],"explanation,":[332],"recently":[336],"challenged.":[337],"suggested":[341],"signal":[344,400],"correlated":[346,357],"evolution":[347,358],"uncovered":[348],"mirrortree":[351],"unrelated":[354],"any":[356],"sites.":[361],"addressed":[364],"this":[365],"controversial":[366],"debate":[367],"field":[370],"studying":[372],"contribution":[374],"correlation":[380],"trees":[383],"showed":[388],"neighborhoods":[391],"have,":[395],"average,":[397],"co-evolutionary":[399,422],"compared":[401],"regions":[404],"outside":[405],"sites;":[407],"although":[408],"when":[409],"neighborhood":[412],"was":[413],"removed,":[414],"remaining":[416],"sequence":[418],"still":[419],"contained":[420],"signal.":[423],"These":[424],"results":[425],"evidence":[427],"role":[430],"co-evolution":[436,443],"contribute":[438],"our":[440],"Our":[447],"domain-centric":[448],"methods":[449],"potential":[452],"incorporated":[455],"into":[456],"translational":[457],"bioinformatics":[458],"characterization":[462],"rare":[464],"variants":[468],"large-scale":[470],"sequencing":[471],"studies.":[472]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}