{"id":"https://openalex.org/W1996437708","doi":"https://doi.org/10.1109/iccabs.2011.5729899","title":"Poster: Comprehensive pharmacogenomic pathway screening by data assimilation","display_name":"Poster: Comprehensive pharmacogenomic pathway screening by data assimilation","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W1996437708","doi":"https://doi.org/10.1109/iccabs.2011.5729899","mag":"1996437708"},"language":"en","primary_location":{"id":"doi:10.1109/iccabs.2011.5729899","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iccabs.2011.5729899","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences (ICCABS)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071376729","display_name":"Takanori Hasegawa","orcid":"https://orcid.org/0000-0001-7251-9950"},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Hasegawa","raw_affiliation_strings":["Human Genome Center, Institute of Medical Science, University of Tokyo, Minato, Tokyo, Japan","Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Center, Institute of Medical Science, University of Tokyo, Minato, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078146127","display_name":"Rui Yamaguchi","orcid":"https://orcid.org/0000-0003-1224-227X"},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rui Yamaguchi","raw_affiliation_strings":["Human Genome Center, Institute of Medical Science, University of Tokyo, Minato, Tokyo, Japan","Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Center, Institute of Medical Science, University of Tokyo, Minato, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025220924","display_name":"Masao Nagasaki","orcid":"https://orcid.org/0000-0002-4292-8785"},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Nagasaki","raw_affiliation_strings":["Human Genome Center, Institute of Medical Science, University of Tokyo, Minato, Tokyo, Japan","Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Center, Institute of Medical Science, University of Tokyo, Minato, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090788230","display_name":"Seiya Imoto","orcid":"https://orcid.org/0000-0002-2989-308X"},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiya Imoto","raw_affiliation_strings":["Human Genome Center, Institute of Medical Science, University of Tokyo, Minato, Tokyo, Japan","Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Center, Institute of Medical Science, University of Tokyo, Minato, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088167618","display_name":"Satoru Miyano","orcid":"https://orcid.org/0000-0002-1753-6616"},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Miyano","raw_affiliation_strings":["Human Genome Center, Institute of Medical Science, University of Tokyo, Minato, Tokyo, Japan","Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Center, Institute of Medical Science, University of Tokyo, Minato, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.11748082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"246","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.749819815158844},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.6024380922317505},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5753074884414673},{"id":"https://openalex.org/keywords/data-assimilation","display_name":"Data assimilation","score":0.5709084868431091},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.5213652849197388},{"id":"https://openalex.org/keywords/bayesian-network","display_name":"Bayesian network","score":0.4967956840991974},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.4629873037338257},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.45929211378097534},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.45502904057502747},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"Pharmacogenomics","score":0.44995927810668945},{"id":"https://openalex.org/keywords/data-modeling","display_name":"Data modeling","score":0.4464600682258606},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.44622135162353516},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.43331700563430786},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.4317362904548645},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.4190346896648407},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35881173610687256},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3056459128856659},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13239958882331848},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.09801539778709412}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.749819815158844},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.6024380922317505},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5753074884414673},{"id":"https://openalex.org/C24552861","wikidata":"https://www.wikidata.org/wiki/Q2670177","display_name":"Data assimilation","level":2,"score":0.5709084868431091},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.5213652849197388},{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.4967956840991974},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.4629873037338257},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.45929211378097534},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.45502904057502747},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.44995927810668945},{"id":"https://openalex.org/C67186912","wikidata":"https://www.wikidata.org/wiki/Q367664","display_name":"Data modeling","level":2,"score":0.4464600682258606},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.44622135162353516},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.43331700563430786},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.4317362904548645},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.4190346896648407},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35881173610687256},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3056459128856659},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13239958882331848},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.09801539778709412},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iccabs.2011.5729899","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iccabs.2011.5729899","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences (ICCABS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W46563058","https://openalex.org/W1968347726","https://openalex.org/W2000278658","https://openalex.org/W2033284638","https://openalex.org/W2108958766","https://openalex.org/W2112963402","https://openalex.org/W2116018370","https://openalex.org/W2116290764","https://openalex.org/W2130177815","https://openalex.org/W2143198897","https://openalex.org/W2144323650","https://openalex.org/W2148523353","https://openalex.org/W2151449559","https://openalex.org/W2154751475","https://openalex.org/W2161080454","https://openalex.org/W2168175751"],"related_works":["https://openalex.org/W2155492529","https://openalex.org/W4252504573","https://openalex.org/W4385510321","https://openalex.org/W15348386","https://openalex.org/W2314128295","https://openalex.org/W1509942269","https://openalex.org/W4287026692","https://openalex.org/W2077895977","https://openalex.org/W2609388058","https://openalex.org/W2132274001"],"abstract_inverted_index":{"Construction":[0],"and":[1,25,33],"simulation":[2,98,135,183],"of":[3,13,23,36,47,86,105,133,153,165,175,181],"biological":[4,14,48],"pathways":[5],"are":[6,28,41,66,120,137,155],"crucial":[7],"steps":[8],"in":[9,16,38,72,110,124],"understanding":[10],"complex":[11],"networks":[12,24],"elements":[15,71],"cells.":[17],"To":[18],"construct":[19],"simulatable":[20,88],"models,":[21,184],"structures":[22,132],"chemical":[26],"reactions":[27],"collected":[29],"from":[30,90,140],"existing":[31],"literature":[32],"the":[34,39,45,73,125,141,151,163,172,176,179],"values":[35,152,164],"parameters":[37,154,166],"model":[40,109],"set":[42,85],"based":[43,52],"on":[44,53],"results":[46],"experiments":[49],"or":[50,70],"estimated":[51,157],"observed":[54,114],"data":[55,115,159],"by":[56,158,170],"some":[57,67],"computational":[58],"method.":[59],"However,":[60],"it":[61],"is":[62,94,129,145],"possible":[63],"that":[64,81,130],"there":[65],"missing":[68],"relationships":[69],"literature-based":[74,92],"networks.":[75],"In":[76],"this":[77],"paper,":[78],"a":[79,84,103],"method":[80],"can":[82],"create":[83],"extended":[87],"models":[89,93,99,136],"prototype":[91],"focused":[95],"on.":[96],"Biological":[97],"were":[100],"formulated":[101],"under":[102],"framework":[104],"nonlinear":[106],"state":[107],"space":[108],"order":[111],"to":[112],"use":[113],"for":[116,147],"parameter":[117],"estimation.":[118],"There":[119],"two":[121],"key":[122],"points":[123],"proposed":[126],"strategy:":[127],"One":[128],"various":[131],"candidate":[134],"systematically":[138],"generated":[139],"prototypes.":[142],"The":[143],"other":[144],"that,":[146],"each":[148],"created":[149],"model,":[150],"automatically":[156],"assimilation":[160],"technique":[161],";":[162],"will":[167],"be":[168],"determined":[169],"maximizing":[171],"prediction":[173],"capability":[174],"model.":[177],"For":[178],"comparison":[180],"multiple":[182],"Bayesian":[185],"information":[186],"criterion":[187],"(BIC)":[188],"was":[189],"employed.":[190]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}