{"id":"https://openalex.org/W3136738297","doi":"https://doi.org/10.1109/icassp39728.2021.9414112","title":"Uncertainty-Based Biological Age Estimation of Brain MRI Scans","display_name":"Uncertainty-Based Biological Age Estimation of Brain MRI Scans","publication_year":2021,"publication_date":"2021-05-13","ids":{"openalex":"https://openalex.org/W3136738297","doi":"https://doi.org/10.1109/icassp39728.2021.9414112","mag":"3136738297"},"language":"en","primary_location":{"id":"doi:10.1109/icassp39728.2021.9414112","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icassp39728.2021.9414112","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ICASSP 2021 - 2021 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)","raw_type":"proceedings-article"},"type":"article","indexed_in":["arxiv","crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2103.08491","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029451273","display_name":"Karim Armanious","orcid":"https://orcid.org/0000-0002-1033-5360"},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Karim Armanious","raw_affiliation_strings":["Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany","University of T\u00fcbingen, T\u00fcbingen, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055793437","display_name":"Sherif Abdulatif","orcid":"https://orcid.org/0000-0001-7498-3773"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sherif Abdulatif","raw_affiliation_strings":["Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102910492","display_name":"Wenbin Shi","orcid":"https://orcid.org/0000-0003-0520-4515"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wenbin Shi","raw_affiliation_strings":["Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102848161","display_name":"Tobias Hepp","orcid":"https://orcid.org/0000-0002-5241-9642"},"institutions":[{"id":"https://openalex.org/I4210135521","display_name":"Max Planck Institute for Intelligent Systems","ror":"https://ror.org/04fq9j139","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210135521"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Hepp","raw_affiliation_strings":["Max Planck Institute for Intelligent Systems, T\u00fcbingen, Germany"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Intelligent Systems, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210135521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080097591","display_name":"Sergios Gatidis","orcid":"https://orcid.org/0000-0002-6928-4967"},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sergios Gatidis","raw_affiliation_strings":["University of T\u00fcbingen, T\u00fcbingen, Germany"],"affiliations":[{"raw_affiliation_string":"University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101717968","display_name":"Bin Yang","orcid":"https://orcid.org/0000-0002-8322-117X"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bin Yang","raw_affiliation_strings":["Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5029451273"],"corresponding_institution_ids":["https://openalex.org/I100066346","https://openalex.org/I8087733"],"apc_list":null,"apc_paid":null,"fwci":0.0969,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35324343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"68","issue":null,"first_page":"1100","last_page":"1104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10036","display_name":"Advanced Neural Network Applications","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10812","display_name":"Human Pose and Action Recognition","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.6732816696166992},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.6572471857070923},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.5627413988113403},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5410164594650269},{"id":"https://openalex.org/keywords/modalities","display_name":"Modalities","score":0.5230672955513},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5139936804771423},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.5038511157035828},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.4764542877674103},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4754226505756378},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.47393304109573364},{"id":"https://openalex.org/keywords/ground-truth","display_name":"Ground truth","score":0.41737794876098633},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.4122636914253235},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.32123100757598877},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2851351499557495},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.22948193550109863},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.211611807346344},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.20396926999092102},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1759667694568634}],"concepts":[{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.6732816696166992},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6572471857070923},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5627413988113403},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5410164594650269},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.5230672955513},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5139936804771423},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.5038511157035828},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4764542877674103},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4754226505756378},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.47393304109573364},{"id":"https://openalex.org/C146849305","wikidata":"https://www.wikidata.org/wiki/Q370766","display_name":"Ground truth","level":2,"score":0.41737794876098633},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.4122636914253235},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.32123100757598877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2851351499557495},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22948193550109863},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.211611807346344},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20396926999092102},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1759667694568634},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/icassp39728.2021.9414112","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icassp39728.2021.9414112","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ICASSP 2021 - 2021 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)","raw_type":"proceedings-article"},{"id":"pmh:oai:arXiv.org:2103.08491","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2103.08491","pdf_url":"https://arxiv.org/pdf/2103.08491","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2103.08491","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2103.08491","pdf_url":"https://arxiv.org/pdf/2103.08491","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1521910923","https://openalex.org/W1844860139","https://openalex.org/W1901129140","https://openalex.org/W1971352522","https://openalex.org/W1994581503","https://openalex.org/W2051771016","https://openalex.org/W2055825262","https://openalex.org/W2105951153","https://openalex.org/W2117398004","https://openalex.org/W2146294536","https://openalex.org/W2164411961","https://openalex.org/W2168228291","https://openalex.org/W2182340639","https://openalex.org/W2279098554","https://openalex.org/W2398808193","https://openalex.org/W2399240576","https://openalex.org/W2421283105","https://openalex.org/W2472806366","https://openalex.org/W2579617530","https://openalex.org/W2599190942","https://openalex.org/W2600383743","https://openalex.org/W2602552939","https://openalex.org/W2612960000","https://openalex.org/W2687611946","https://openalex.org/W2751741310","https://openalex.org/W2770352317","https://openalex.org/W2790211570","https://openalex.org/W2893956025","https://openalex.org/W2897079521","https://openalex.org/W2900036986","https://openalex.org/W2900135733","https://openalex.org/W2908077673","https://openalex.org/W2919877669","https://openalex.org/W2949288398","https://openalex.org/W2949412596","https://openalex.org/W2951266961","https://openalex.org/W2952009394","https://openalex.org/W2963524571","https://openalex.org/W2963630676","https://openalex.org/W2965049427","https://openalex.org/W2995808388","https://openalex.org/W3000235681","https://openalex.org/W3003951577","https://openalex.org/W3009294132","https://openalex.org/W3021216971","https://openalex.org/W3023169602","https://openalex.org/W3026423518","https://openalex.org/W3042569426","https://openalex.org/W3087251728","https://openalex.org/W3091386366","https://openalex.org/W3092596753","https://openalex.org/W3102846594","https://openalex.org/W3137989279","https://openalex.org/W4206734100","https://openalex.org/W4256342650","https://openalex.org/W6639824700","https://openalex.org/W6681057769","https://openalex.org/W6684827145","https://openalex.org/W6695314431","https://openalex.org/W6735443497","https://openalex.org/W6764214684","https://openalex.org/W6772352366","https://openalex.org/W6774292599","https://openalex.org/W6776701191","https://openalex.org/W6777398025","https://openalex.org/W6784418254"],"related_works":["https://openalex.org/W2185469136","https://openalex.org/W2327340211","https://openalex.org/W2011264131","https://openalex.org/W2027542625","https://openalex.org/W4292199793","https://openalex.org/W2282195379","https://openalex.org/W2089784006","https://openalex.org/W2295388821","https://openalex.org/W2102312026","https://openalex.org/W4296095749"],"abstract_inverted_index":{"Age":[0],"is":[1,107],"an":[2],"essential":[3],"factor":[4],"in":[5,176],"modern":[6],"diagnostic":[7],"procedures.":[8],"However,":[9,50],"assessment":[10],"of":[11,25],"the":[12,23,92,98,116,121,136,141,147,165,168,172],"true":[13,142],"biological":[14],"age":[15,94],"(BA)":[16],"remains":[17],"a":[18,46,71,86,132,151],"daunting":[19],"task":[20],"due":[21,59],"to":[22,36,60,110],"lack":[24],"reference":[26],"ground-truth":[27],"labels.":[28],"Current":[29],"BA":[30,48,76,143],"estimation":[31,77],"approaches":[32],"are":[33],"either":[34],"restricted":[35],"skeletal":[37],"images":[38],"or":[39],"rely":[40],"on":[41,120,135,150],"non-imaging":[42],"modalities":[43],"that":[44,130],"yield":[45],"whole-body":[47],"assessment.":[49],"various":[51],"organ":[52],"systems":[53],"may":[54],"exhibit":[55],"different":[56],"aging":[57,113],"characteristics":[58],"lifestyle":[61],"and":[62,171],"genetic":[63],"factors.":[64],"In":[65,125],"this":[66,89,126],"initial":[67],"study,":[68],"we":[69,128],"propose":[70],"new":[72,133],"framework":[73,90],"for":[74],"organ-specific":[75],"utilizing":[78],"3D":[79],"magnetic":[80],"resonance":[81],"image":[82],"(MRI)":[83],"scans.":[84],"As":[85],"first":[87],"step,":[88],"predicts":[91],"chronological":[93],"(CA)":[95],"together":[96],"with":[97],"corresponding":[99],"patient-dependent":[100],"aleatoric":[101],"uncertainty.":[102],"An":[103],"iterative":[104],"training":[105,131],"algorithm":[106],"then":[108],"utilized":[109],"segregate":[111],"atypical":[112],"patients":[114],"from":[115],"given":[117],"population":[118,138],"based":[119],"predicted":[122,169],"uncertainty":[123],"scores.":[124],"manner,":[127],"hypothesize":[129],"model":[134],"remaining":[137],"should":[139],"approximate":[140],"behavior.":[144],"We":[145,163],"apply":[146],"proposed":[148],"methodology":[149],"brain":[152],"MRI":[153],"dataset":[154],"containing":[155],"healthy":[156],"individuals":[157],"as":[158,160],"well":[159],"Alzheimer\u2019s":[161,177],"patients.":[162,178],"demonstrate":[164],"correlation":[166],"between":[167],"BAs":[170],"expected":[173],"cognitive":[174],"deterioration":[175]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
