{"id":"https://openalex.org/W2035514127","doi":"https://doi.org/10.1109/icassp.2013.6637834","title":"Sparse biologically-constrained optimal perturbation of gene regulatory networks","display_name":"Sparse biologically-constrained optimal perturbation of gene regulatory networks","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W2035514127","doi":"https://doi.org/10.1109/icassp.2013.6637834","mag":"2035514127"},"language":"en","primary_location":{"id":"doi:10.1109/icassp.2013.6637834","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icassp.2013.6637834","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Acoustics, Speech and Signal Processing","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100427170","display_name":"Haoyu Wang","orcid":"https://orcid.org/0000-0001-6647-598X"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Haoyu Wang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Illinois, Chicago, USA","Dept. of Electr. & Comput. Eng., Univ. of Illinois at Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Illinois, Chicago, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng., Univ. of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041401460","display_name":"Nidhal Bouaynaya","orcid":"https://orcid.org/0000-0002-8833-8414"},"institutions":[{"id":"https://openalex.org/I102401767","display_name":"University of Arkansas at Little Rock","ror":"https://ror.org/04fttyv97","country_code":"US","type":"education","lineage":["https://openalex.org/I102401767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nidhal Bouaynaya","raw_affiliation_strings":["Department of Systems Engineering, University of Arkansas at Little Rock, USA","[Department of Systems Engineering, University of Arkansas at Little Rock, Little Rock, AR, USA]"],"affiliations":[{"raw_affiliation_string":"Department of Systems Engineering, University of Arkansas at Little Rock, USA","institution_ids":["https://openalex.org/I102401767"]},{"raw_affiliation_string":"[Department of Systems Engineering, University of Arkansas at Little Rock, Little Rock, AR, USA]","institution_ids":["https://openalex.org/I102401767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028887750","display_name":"Roman Shterenberg","orcid":"https://orcid.org/0000-0001-7088-5711"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roman Shterenberg","raw_affiliation_strings":["Department of Mathematics, University of Alabama at Birmingham, USA","Dept. of Math., Univ. of Alabama at Birmingham, Birmingham, AL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Alabama at Birmingham, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Dept. of Math., Univ. of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081723612","display_name":"Dan Schonfeld","orcid":"https://orcid.org/0000-0002-2772-4821"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Schonfeld","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Illinois, Chicago, USA","Dept. of Electr. & Comput. Eng., Univ. of Illinois at Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Illinois, Chicago, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng., Univ. of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100427170"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":null,"apc_paid":null,"fwci":0.1462,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5558313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1167","last_page":"1171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.7958347797393799},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.7635018229484558},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5275632739067078},{"id":"https://openalex.org/keywords/stochastic-matrix","display_name":"Stochastic matrix","score":0.5249740481376648},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4983220100402832},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.4519505202770233},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.37247514724731445},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.37037014961242676},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.31920987367630005},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.23118427395820618},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22301629185676575},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22196868062019348},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1953776478767395},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.10672318935394287},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08538687229156494},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.08122426271438599}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.7958347797393799},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.7635018229484558},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5275632739067078},{"id":"https://openalex.org/C49555168","wikidata":"https://www.wikidata.org/wiki/Q176583","display_name":"Stochastic matrix","level":3,"score":0.5249740481376648},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4983220100402832},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.4519505202770233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37247514724731445},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.37037014961242676},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.31920987367630005},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.23118427395820618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22301629185676575},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22196868062019348},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1953776478767395},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.10672318935394287},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08538687229156494},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.08122426271438599},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icassp.2013.6637834","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icassp.2013.6637834","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Conference on Acoustics, Speech and Signal Processing","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1532781952","https://openalex.org/W1651215666","https://openalex.org/W1968469956","https://openalex.org/W1980138510","https://openalex.org/W2001489471","https://openalex.org/W2059744016","https://openalex.org/W2077895748","https://openalex.org/W2086150890","https://openalex.org/W2098432798","https://openalex.org/W2106034845","https://openalex.org/W2107040525","https://openalex.org/W2121782762","https://openalex.org/W2131441237","https://openalex.org/W2134978629","https://openalex.org/W2137324353","https://openalex.org/W2139058887","https://openalex.org/W2152965497","https://openalex.org/W2155619559","https://openalex.org/W2160220288","https://openalex.org/W2160904474","https://openalex.org/W2165350808","https://openalex.org/W2169765391","https://openalex.org/W2169937880"],"related_works":["https://openalex.org/W2599841037","https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2114466827","https://openalex.org/W2791736663","https://openalex.org/W2129949791","https://openalex.org/W2806770614","https://openalex.org/W1710460698","https://openalex.org/W249159571","https://openalex.org/W2131550814"],"abstract_inverted_index":{"This":[0],"paper":[1],"derives":[2],"a":[3],"sparse":[4],"optimal":[5,14,46,109],"perturbation":[6,15,47,63,110],"of":[7,16,20,48,64,67,90,107,111,116],"gene":[8,40,84,95],"regulatory":[9,41,85],"networks":[10,42],"by":[11,43],"determining":[12],"the":[13,17,25,45,49,65,71,81,88,91,100,105,108,112,117],"minimal":[18],"number":[19],"individual":[21,68],"genes":[22],"that":[23],"force":[24],"network":[26,86],"to":[27,37,62,94,99],"settle":[28],"into":[29],"desired":[30],"equilibrium":[31],"states.":[32],"Previous":[33],"efforts":[34],"have":[35],"led":[36],"intervention":[38],"in":[39,56,97],"deriving":[44],"state":[50,66,72],"probability":[51,73,113],"transition":[52,74,114],"matrix.":[53,75],"Current":[54],"technology":[55],"molecular":[57],"biology,":[58],"however,":[59],"is":[60],"limited":[61],"genes,":[69],"not":[70],"Our":[76],"computer":[77],"simulation":[78],"experiments":[79],"on":[80,104],"Human":[82],"melanoma":[83],"demonstrate":[87],"superiority":[89],"proposed":[92],"approach":[93],"regulation":[96],"comparison":[98],"previous":[101],"methods":[102],"based":[103],"marginal":[106],"matrix":[115],"network.":[118]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
