{"id":"https://openalex.org/W2128721420","doi":"https://doi.org/10.1109/icassp.2012.6287981","title":"Unsupervised wrinkle detection in reflectance confocal microscopy images of the human skin","display_name":"Unsupervised wrinkle detection in reflectance confocal microscopy images of the human skin","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W2128721420","doi":"https://doi.org/10.1109/icassp.2012.6287981","mag":"2128721420"},"language":"en","primary_location":{"id":"doi:10.1109/icassp.2012.6287981","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icassp.2012.6287981","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029980254","display_name":"Jamshid Sourati","orcid":"https://orcid.org/0000-0002-4893-2793"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Sourati","raw_affiliation_strings":["Northeastern University, Northeastern University, Boston, MA, USA","Northeastern University, Boston, MA 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Northeastern University, Boston, MA, USA","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079980080","display_name":"Dana H. Brooks","orcid":"https://orcid.org/0000-0003-3231-6715"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. H. Brooks","raw_affiliation_strings":["Northeastern University, Northeastern University, Boston, MA, USA","Northeastern University, Boston, MA 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Northeastern University, Boston, MA, USA","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042038501","display_name":"Jennifer Dy","orcid":"https://orcid.org/0000-0002-8430-134X"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. G. Dy","raw_affiliation_strings":["Northeastern University, Northeastern University, Boston, MA, USA","Northeastern University, Boston, MA 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Northeastern University, Boston, MA, USA","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070055975","display_name":"Esra Ataer-Cans\u0131zo\u011flu","orcid":"https://orcid.org/0000-0002-1941-4241"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Ataer-Cansizoglu","raw_affiliation_strings":["Northeastern University, Northeastern University, Boston, MA, USA","Northeastern University, Boston, MA 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Northeastern University, Boston, MA, USA","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083261801","display_name":"Deniz Erdo\u011fmu\u015f","orcid":"https://orcid.org/0000-0002-1114-3539"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Erdogmus","raw_affiliation_strings":["Northeastern University, Northeastern University, Boston, MA, USA","Northeastern University, Boston, MA 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Northeastern University, Boston, MA, USA","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011252033","display_name":"Milind Rajadhyaksha","orcid":"https://orcid.org/0000-0002-6323-4547"},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Rajadhyaksha","raw_affiliation_strings":["Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","Memorial Sloan-Kettering Cancer Center, Dermatology Service, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, Dermatology Service, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15447308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"705","last_page":"708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9818000197410583,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wrinkle","display_name":"Wrinkle","score":0.8812109231948853},{"id":"https://openalex.org/keywords/dermis","display_name":"Dermis","score":0.7869018316268921},{"id":"https://openalex.org/keywords/epidermis","display_name":"Epidermis (zoology)","score":0.7196276783943176},{"id":"https://openalex.org/keywords/confocal-microscopy","display_name":"Confocal microscopy","score":0.5952476263046265},{"id":"https://openalex.org/keywords/confocal","display_name":"Confocal","score":0.5748838186264038},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5535408854484558},{"id":"https://openalex.org/keywords/human-skin","display_name":"Human skin","score":0.496223509311676},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.40205299854278564},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3698316812515259},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3634772300720215},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.22977042198181152},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.2253861427307129},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21652734279632568},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.21545517444610596},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14299684762954712},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10333016514778137}],"concepts":[{"id":"https://openalex.org/C2777872592","wikidata":"https://www.wikidata.org/wiki/Q349185","display_name":"Wrinkle","level":2,"score":0.8812109231948853},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.7869018316268921},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.7196276783943176},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.5952476263046265},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.5748838186264038},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5535408854484558},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.496223509311676},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40205299854278564},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3698316812515259},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3634772300720215},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.22977042198181152},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2253861427307129},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21652734279632568},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21545517444610596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14299684762954712},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10333016514778137},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icassp.2012.6287981","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icassp.2012.6287981","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1974954013","https://openalex.org/W2025818287","https://openalex.org/W2044688110","https://openalex.org/W2092861178","https://openalex.org/W2115755118","https://openalex.org/W2165750453"],"related_works":["https://openalex.org/W2726111829","https://openalex.org/W4250585504","https://openalex.org/W2008049857","https://openalex.org/W1978803831","https://openalex.org/W2105513520","https://openalex.org/W1543172254","https://openalex.org/W2580002495","https://openalex.org/W2056668469","https://openalex.org/W82035557","https://openalex.org/W4285171187"],"abstract_inverted_index":{"Reflectance":[0],"confocal":[1],"microscopy":[2],"(RCM)":[3],"is":[4,25,43],"a":[5,28,44,82,103,127],"non-invasive":[6],"and":[7,54,60,124],"in-vivo":[8],"imaging":[9],"modality,":[10],"which":[11],"can":[12,78],"take":[13],"images":[14],"from":[15],"different":[16,115],"depths":[17],"of":[18,33,48,52,72,89],"the":[19,34,36,49,64,73,87,95,112],"human":[20],"skin.":[21,74],"A":[22],"challenging":[23],"problem":[24,46],"to":[26],"detect":[27],"clinically":[29],"important":[30],"subsurface":[31],"section":[32],"skin,":[35],"Dermis/Epidermis":[37],"junction,":[38],"in":[39,94],"RCM":[40,108,116],"images.":[41,109],"This":[42,75],"tough":[45],"because":[47],"huge":[50],"variation":[51],"texture":[53],"intensity":[55],"features":[56],"across":[57],"both":[58],"intersubject":[59],"intrasubject":[61],"tissues.":[62],"On":[63],"other":[65],"hand,":[66],"there's":[67],"almost":[68],"no":[69],"wrinkle-free":[70],"part":[71],"well-known":[76],"phenomenon":[77],"be":[79],"used":[80],"as":[81],"histological":[83],"clue":[84],"for":[85,107],"guessing":[86],"probability":[88],"being":[90],"Dermis":[91],"or":[92],"Epidermis":[93],"neighboring":[96],"regions.":[97],"In":[98],"this":[99],"paper,":[100],"we":[101,118],"develop":[102],"two-step":[104],"wrinkle":[105],"detector":[106],"By":[110],"analyzing":[111],"results":[113],"on":[114],"images,":[117],"conclude":[119],"it":[120],"has":[121],"high":[122],"sensitivity":[123],"specificity,":[125],"but":[126],"relatively":[128],"lower":[129],"Jaccard":[130],"index.":[131]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}