{"id":"https://openalex.org/W2774681181","doi":"https://doi.org/10.1109/icacci.2017.8125891","title":"Computational modelling of apoptosis in parkinson's disease using biochemical systems theory","display_name":"Computational modelling of apoptosis in parkinson's disease using biochemical systems theory","publication_year":2017,"publication_date":"2017-09-01","ids":{"openalex":"https://openalex.org/W2774681181","doi":"https://doi.org/10.1109/icacci.2017.8125891","mag":"2774681181"},"language":"en","primary_location":{"id":"doi:10.1109/icacci.2017.8125891","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icacci.2017.8125891","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 International Conference on Advances in Computing, Communications and Informatics (ICACCI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087946457","display_name":"Hemalatha Sasidharakurup","orcid":"https://orcid.org/0009-0000-4309-4893"},"institutions":[{"id":"https://openalex.org/I81556334","display_name":"Amrita Vishwa Vidyapeetham","ror":"https://ror.org/03am10p12","country_code":"IN","type":"education","lineage":["https://openalex.org/I81556334"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Hemalatha Sasidharakurup","raw_affiliation_strings":["Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham(Amrita University), Kollam, Kerala, India"],"affiliations":[{"raw_affiliation_string":"Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham(Amrita University), Kollam, Kerala, India","institution_ids":["https://openalex.org/I81556334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017631143","display_name":"Pyaree Mohan Dash","orcid":"https://orcid.org/0000-0002-1005-0437"},"institutions":[{"id":"https://openalex.org/I81556334","display_name":"Amrita Vishwa Vidyapeetham","ror":"https://ror.org/03am10p12","country_code":"IN","type":"education","lineage":["https://openalex.org/I81556334"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pyaree Dash","raw_affiliation_strings":["Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham(Amrita University), Kollam, Kerala, India"],"affiliations":[{"raw_affiliation_string":"Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham(Amrita University), Kollam, Kerala, India","institution_ids":["https://openalex.org/I81556334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063781474","display_name":"Asha Vijayan","orcid":"https://orcid.org/0000-0002-4388-3881"},"institutions":[{"id":"https://openalex.org/I81556334","display_name":"Amrita Vishwa Vidyapeetham","ror":"https://ror.org/03am10p12","country_code":"IN","type":"education","lineage":["https://openalex.org/I81556334"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Asha Vijayan","raw_affiliation_strings":["Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham(Amrita University), Kollam, Kerala, India"],"affiliations":[{"raw_affiliation_string":"Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham(Amrita University), Kollam, Kerala, India","institution_ids":["https://openalex.org/I81556334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043020478","display_name":"Bipin G. Nair","orcid":"https://orcid.org/0000-0002-4944-8805"},"institutions":[{"id":"https://openalex.org/I81556334","display_name":"Amrita Vishwa Vidyapeetham","ror":"https://ror.org/03am10p12","country_code":"IN","type":"education","lineage":["https://openalex.org/I81556334"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bipin Nair","raw_affiliation_strings":["Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham(Amrita University), Kollam, Kerala, India"],"affiliations":[{"raw_affiliation_string":"Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham(Amrita University), Kollam, Kerala, India","institution_ids":["https://openalex.org/I81556334"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066357721","display_name":"Shyam Diwakar","orcid":"https://orcid.org/0000-0003-1546-0184"},"institutions":[{"id":"https://openalex.org/I81556334","display_name":"Amrita Vishwa Vidyapeetham","ror":"https://ror.org/03am10p12","country_code":"IN","type":"education","lineage":["https://openalex.org/I81556334"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shyam Diwakar","raw_affiliation_strings":["Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham(Amrita University), Kollam, Kerala, India"],"affiliations":[{"raw_affiliation_string":"Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham(Amrita University), Kollam, Kerala, India","institution_ids":["https://openalex.org/I81556334"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5087946457"],"corresponding_institution_ids":["https://openalex.org/I81556334"],"apc_list":null,"apc_paid":null,"fwci":0.5072,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6889172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1229","last_page":"1235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopaminergic","display_name":"Dopaminergic","score":0.6542083024978638},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.6371787190437317},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"Oxidative stress","score":0.6036885976791382},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.5943171977996826},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48671582341194153},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.48002591729164124},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4796641170978546},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.477438747882843},{"id":"https://openalex.org/keywords/cellular-model","display_name":"Cellular model","score":0.47161227464675903},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.4319569170475006},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3105342984199524},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.30548909306526184},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.3051682710647583},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20839610695838928},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10055986046791077},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08101469278335571},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.07286408543586731},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.06561633944511414}],"concepts":[{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6542083024978638},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6371787190437317},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6036885976791382},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5943171977996826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48671582341194153},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48002591729164124},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4796641170978546},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.477438747882843},{"id":"https://openalex.org/C147025567","wikidata":"https://www.wikidata.org/wiki/Q16335140","display_name":"Cellular model","level":3,"score":0.47161227464675903},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4319569170475006},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3105342984199524},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.30548909306526184},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3051682710647583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20839610695838928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10055986046791077},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08101469278335571},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07286408543586731},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06561633944511414},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icacci.2017.8125891","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icacci.2017.8125891","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 International Conference on Advances in Computing, Communications and Informatics (ICACCI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1524718556","https://openalex.org/W1526893351","https://openalex.org/W1877873625","https://openalex.org/W1925696976","https://openalex.org/W1972940559","https://openalex.org/W1980165666","https://openalex.org/W1980905317","https://openalex.org/W1984636849","https://openalex.org/W1990048226","https://openalex.org/W1994711799","https://openalex.org/W2013942803","https://openalex.org/W2042312044","https://openalex.org/W2063495408","https://openalex.org/W2066047436","https://openalex.org/W2068336834","https://openalex.org/W2075570199","https://openalex.org/W2080389159","https://openalex.org/W2083119293","https://openalex.org/W2085904032","https://openalex.org/W2087848764","https://openalex.org/W2089082314","https://openalex.org/W2093272805","https://openalex.org/W2099410111","https://openalex.org/W2117724384","https://openalex.org/W2119807130","https://openalex.org/W2125016438","https://openalex.org/W2127993518","https://openalex.org/W2128471322","https://openalex.org/W2130008185","https://openalex.org/W2142940765","https://openalex.org/W2151198603","https://openalex.org/W2151982496","https://openalex.org/W2155167337","https://openalex.org/W2162445214","https://openalex.org/W2164314374","https://openalex.org/W2322912881","https://openalex.org/W2397750541","https://openalex.org/W3095976102"],"related_works":["https://openalex.org/W3092411928","https://openalex.org/W2021873022","https://openalex.org/W2388200580","https://openalex.org/W4205296828","https://openalex.org/W3027081464","https://openalex.org/W4229779921","https://openalex.org/W2059208649","https://openalex.org/W1978306434","https://openalex.org/W1983445268","https://openalex.org/W2055526699"],"abstract_inverted_index":{"In":[0,94],"this":[1],"study,":[2],"we":[3],"present":[4],"a":[5,33],"computational":[6],"model":[7,31,76,111],"of":[8,26,35,98,121,131,137],"Parkinson's":[9],"disease":[10],"(PD)":[11],"that":[12,17],"includes":[13],"different":[14],"biological":[15],"interactions":[16],"leads":[18,133],"to":[19,75,91,134,156],"neural":[20],"cell":[21],"death":[22],"with":[23,166],"the":[24,77,96,116,135,152,157],"use":[25],"biochemical":[27,59],"systems":[28,60],"theory.":[29,61],"The":[30,118],"incorporates":[32],"set":[34],"important":[36],"pathways":[37,53],"in":[38,70,88,105,115,141,151],"PD":[39,153],"including":[40],"dopaminergic":[41,82],"pathway,":[42],"mitochondrial":[43,109],"pathway":[44,84,110],"and":[45,54,72,102,123,127,144,163],"P53":[46],"-":[47],"DNA":[48],"damage":[49],"pathway.":[50],"Modeling":[51],"signaling":[52],"simulations":[55,128],"were":[56,73,125],"performed":[57],"using":[58],"Initial":[62],"concentrations":[63],"have":[64,112],"been":[65,113,149],"taken":[66],"from":[67],"experimental":[68],"data":[69],"literature":[71],"used":[74],"changes.":[78],"Results":[79],"generated":[80],"by":[81],"diseased":[83,106,164],"show":[85],"45%":[86],"decrease":[87],"dopamine,":[89],"compared":[90,155],"normal":[92,162],"condition.":[93],"addition,":[95],"activity":[97],"MOMP,":[99],"Caspase":[100],"9":[101],"Apoptosome":[103],"expression":[104,119],"condition":[107],"within":[108],"observed":[114,150],"results.":[117],"levels":[120],"BAX":[122],"MOMP":[124],"reconstructed":[126],"suggest":[129],"oligomerization":[130],"BAK":[132],"elevation":[136],"MOMP.":[138],"An":[139],"increase":[140],"oxidative":[142],"stress":[143],"apoptosis":[145],"level":[146],"also":[147],"has":[148],"condition,":[154],"control":[158],"allowing":[159],"comparisons":[160],"between":[161],"conditions":[165],"these":[167],"mathematical":[168],"models.":[169]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}