{"id":"https://openalex.org/W2545946084","doi":"https://doi.org/10.1109/iarwisoci.2014.7034638","title":"A model of tumor growth coupling a cellular biomodel with biomechanical simulations","display_name":"A model of tumor growth coupling a cellular biomodel with biomechanical simulations","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2545946084","doi":"https://doi.org/10.1109/iarwisoci.2014.7034638","mag":"2545946084"},"language":"en","primary_location":{"id":"doi:10.1109/iarwisoci.2014.7034638","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iarwisoci.2014.7034638","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation - The CHIC Project Workshop (IARWISOCI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019278445","display_name":"Farhad R. Nezami","orcid":"https://orcid.org/0000-0002-4210-3177"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Farhad Rikhtegar","raw_affiliation_strings":["Institute for Surgical Technology & Biomechanics, University of Bern, Bern, Switzerland"],"affiliations":[{"raw_affiliation_string":"Institute for Surgical Technology & Biomechanics, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030318381","display_name":"Eleni Kolokotroni","orcid":"https://orcid.org/0000-0001-8455-2918"},"institutions":[{"id":"https://openalex.org/I4210144519","display_name":"Institute of Communication and Computer Systems","ror":"https://ror.org/0483fn738","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210144519"]},{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Kolokotroni","raw_affiliation_strings":["Institute of Communication and Computer Systems, National Technical University of Athens, Greece"],"affiliations":[{"raw_affiliation_string":"Institute of Communication and Computer Systems, National Technical University of Athens, Greece","institution_ids":["https://openalex.org/I4210144519","https://openalex.org/I174458059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058750242","display_name":"Georgios Stamatakos","orcid":"https://orcid.org/0000-0003-2054-477X"},"institutions":[{"id":"https://openalex.org/I4210144519","display_name":"Institute of Communication and Computer Systems","ror":"https://ror.org/0483fn738","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210144519"]},{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios Stamatakos","raw_affiliation_strings":["Institute of Communication and Computer Systems, National Technical University of Athens, Greece"],"affiliations":[{"raw_affiliation_string":"Institute of Communication and Computer Systems, National Technical University of Athens, Greece","institution_ids":["https://openalex.org/I4210144519","https://openalex.org/I174458059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055346737","display_name":"Philippe B\u00fcchler","orcid":"https://orcid.org/0000-0002-8390-4827"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4210092485","display_name":"Bioengineering (Switzerland)","ror":"https://ror.org/00m2xfz17","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210092485"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Philippe Buchler","raw_affiliation_strings":["Computational Bioengineering Group, University of Bern, Bern, Switzerland"],"affiliations":[{"raw_affiliation_string":"Computational Bioengineering Group, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I4210092485"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019278445"],"corresponding_institution_ids":["https://openalex.org/I118564535"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.23079914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiphysics","display_name":"Multiphysics","score":0.8640545606613159},{"id":"https://openalex.org/keywords/lung-tumor","display_name":"Lung tumor","score":0.6697714328765869},{"id":"https://openalex.org/keywords/tumor-cells","display_name":"Tumor cells","score":0.5142066478729248},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45972129702568054},{"id":"https://openalex.org/keywords/coupling","display_name":"Coupling (piping)","score":0.42674872279167175},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3795948922634125},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22569984197616577},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.204371839761734},{"id":"https://openalex.org/keywords/finite-element-method","display_name":"Finite element method","score":0.1988530457019806},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18860268592834473},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.16970813274383545},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.1606680154800415},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15403729677200317},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.11623543500900269},{"id":"https://openalex.org/keywords/structural-engineering","display_name":"Structural engineering","score":0.11139893531799316}],"concepts":[{"id":"https://openalex.org/C46435376","wikidata":"https://www.wikidata.org/wiki/Q1829750","display_name":"Multiphysics","level":3,"score":0.8640545606613159},{"id":"https://openalex.org/C3018373657","wikidata":"https://www.wikidata.org/wiki/Q15124212","display_name":"Lung tumor","level":3,"score":0.6697714328765869},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.5142066478729248},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45972129702568054},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.42674872279167175},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3795948922634125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22569984197616577},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.204371839761734},{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.1988530457019806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18860268592834473},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.16970813274383545},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1606680154800415},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15403729677200317},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.11623543500900269},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.11139893531799316}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iarwisoci.2014.7034638","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iarwisoci.2014.7034638","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation - The CHIC Project Workshop (IARWISOCI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1973676285","https://openalex.org/W1976110908","https://openalex.org/W1977281992","https://openalex.org/W1997076326","https://openalex.org/W2002371619","https://openalex.org/W2052569390","https://openalex.org/W2079017595","https://openalex.org/W2122975102","https://openalex.org/W2129482170","https://openalex.org/W2153477637","https://openalex.org/W4255862670","https://openalex.org/W6837980903"],"related_works":["https://openalex.org/W2084426624","https://openalex.org/W3026055904","https://openalex.org/W2792869497","https://openalex.org/W4312133600","https://openalex.org/W2567205727","https://openalex.org/W2361803029","https://openalex.org/W4231438905","https://openalex.org/W2421752387","https://openalex.org/W2325369521","https://openalex.org/W2469384920"],"abstract_inverted_index":{"The":[0,38,66,105],"aim":[1],"of":[2,10,47,58,75,102],"this":[3],"paper":[4],"is":[5,42,98],"to":[6,16,29,44,72],"present":[7],"the":[8,51,55,59,63,73,83,91,96,116,124],"development":[9],"a":[11,35,120],"multi-scale":[12],"and":[13,27,77,126],"multiphysics":[14],"approach":[15,85,106],"tumor":[17,25,60,93,97,113],"growth.":[18],"An":[19],"existing":[20],"biomodel":[21],"used":[22,43,109],"for":[23,112],"clinical":[24],"growth":[26],"response":[28],"treatment":[30,125],"has":[31,69],"been":[32,70],"coupled":[33,84],"with":[34],"biomechanical":[36],"model.":[37],"macroscopic":[39],"mechanical":[40],"model":[41,68],"provide":[45],"directions":[46],"least":[48],"pressure":[49],"in":[50,100,110,123],"tissue,":[52],"which":[53],"drives":[54],"geometrical":[56],"evolution":[57],"predicted":[61],"at":[62],"cellular":[64],"level.":[65],"combined":[67],"applied":[71],"case":[74],"brain":[76],"lung":[78],"tumors.":[79],"Results":[80],"indicated":[81],"that":[82],"provides":[86],"additional":[87],"morphological":[88],"information":[89,118],"on":[90],"realistic":[92],"shape":[94],"when":[95],"located":[99],"regions":[101],"tissue":[103],"inhomogeneity.":[104],"might":[107],"be":[108],"oncosimulators":[111],"types":[114],"where":[115],"morphometry":[117],"plays":[119],"major":[121],"role":[122],"surgical":[127],"planning.":[128]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}