{"id":"https://openalex.org/W2972603022","doi":"https://doi.org/10.1109/i2mtc.2019.8827017","title":"Label-free Detection of Breast Cancer Cells Using a Fiber-optic Grating Sensor Functionalized with Halloysite Nanotubes","display_name":"Label-free Detection of Breast Cancer Cells Using a Fiber-optic Grating Sensor Functionalized with Halloysite Nanotubes","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2972603022","doi":"https://doi.org/10.1109/i2mtc.2019.8827017","mag":"2972603022"},"language":"en","primary_location":{"id":"doi:10.1109/i2mtc.2019.8827017","is_oa":false,"landing_page_url":"https://doi.org/10.1109/i2mtc.2019.8827017","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE International Instrumentation and Measurement Technology Conference (I2MTC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100423096","display_name":"Xia Chen","orcid":"https://orcid.org/0000-0002-0994-5401"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xia Chen","raw_affiliation_strings":["Institute of Photonics Technology, Jinan University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Institute of Photonics Technology, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074615283","display_name":"Tuan Guo","orcid":"https://orcid.org/0000-0001-6189-1335"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tuan Guo","raw_affiliation_strings":["Institute of Photonics Technology, Jinan University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Institute of Photonics Technology, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103236880","display_name":"Xiujuan Zhao","orcid":"https://orcid.org/0000-0002-3188-9514"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiujuan Zhao","raw_affiliation_strings":["College of Chemistry and Materials, Jinan University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"College of Chemistry and Materials, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038667152","display_name":"Mingxian Liu","orcid":"https://orcid.org/0000-0002-5466-3024"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingxian Liu","raw_affiliation_strings":["College of Chemistry and Materials, Jinan University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"College of Chemistry and Materials, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100423096"],"corresponding_institution_ids":["https://openalex.org/I159948400"],"apc_list":null,"apc_paid":null,"fwci":0.1192,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4644637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"85","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10205","display_name":"Advanced Fiber Optic Sensors","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10205","display_name":"Advanced Fiber Optic Sensors","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10299","display_name":"Photonic and Optical Devices","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10666","display_name":"Photonic Crystals and Applications","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.784133791923523},{"id":"https://openalex.org/keywords/detection-limit","display_name":"Detection limit","score":0.6874099373817444},{"id":"https://openalex.org/keywords/halloysite","display_name":"Halloysite","score":0.6408399939537048},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.6381442546844482},{"id":"https://openalex.org/keywords/optical-fiber","display_name":"Optical fiber","score":0.5764828324317932},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.5353978276252747},{"id":"https://openalex.org/keywords/fiber-bragg-grating","display_name":"Fiber Bragg grating","score":0.5333480834960938},{"id":"https://openalex.org/keywords/reproducibility","display_name":"Reproducibility","score":0.5202861428260803},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4684581756591797},{"id":"https://openalex.org/keywords/coating","display_name":"Coating","score":0.44416943192481995},{"id":"https://openalex.org/keywords/circulating-tumor-cell","display_name":"Circulating tumor cell","score":0.4383869469165802},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.42940133810043335},{"id":"https://openalex.org/keywords/analyte","display_name":"Analyte","score":0.42124396562576294},{"id":"https://openalex.org/keywords/fiber","display_name":"Fiber","score":0.4168879985809326},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.41283851861953735},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3975669741630554},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.31425565481185913},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.17841660976409912},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.12074819207191467},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.11594590544700623},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.0926128625869751}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.784133791923523},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.6874099373817444},{"id":"https://openalex.org/C2777135253","wikidata":"https://www.wikidata.org/wiki/Q12821923","display_name":"Halloysite","level":2,"score":0.6408399939537048},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6381442546844482},{"id":"https://openalex.org/C194232370","wikidata":"https://www.wikidata.org/wiki/Q162","display_name":"Optical fiber","level":2,"score":0.5764828324317932},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.5353978276252747},{"id":"https://openalex.org/C43091971","wikidata":"https://www.wikidata.org/wiki/Q1397391","display_name":"Fiber Bragg grating","level":3,"score":0.5333480834960938},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.5202861428260803},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4684581756591797},{"id":"https://openalex.org/C2781448156","wikidata":"https://www.wikidata.org/wiki/Q1570182","display_name":"Coating","level":2,"score":0.44416943192481995},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.4383869469165802},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42940133810043335},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.42124396562576294},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.4168879985809326},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.41283851861953735},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3975669741630554},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.31425565481185913},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17841660976409912},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.12074819207191467},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11594590544700623},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0926128625869751},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.0},{"id":"https://openalex.org/C6260449","wikidata":"https://www.wikidata.org/wiki/Q41364","display_name":"Wavelength","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/i2mtc.2019.8827017","is_oa":false,"landing_page_url":"https://doi.org/10.1109/i2mtc.2019.8827017","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE International Instrumentation and Measurement Technology Conference (I2MTC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7699999809265137}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1853223623","https://openalex.org/W1968063242","https://openalex.org/W1974756617","https://openalex.org/W1983653920","https://openalex.org/W2023500894","https://openalex.org/W2059201273","https://openalex.org/W2083278718","https://openalex.org/W2088674046","https://openalex.org/W2091967829","https://openalex.org/W2108550639","https://openalex.org/W2140782011","https://openalex.org/W2148756620","https://openalex.org/W2158558808","https://openalex.org/W2164697448","https://openalex.org/W2468997318","https://openalex.org/W2779771362","https://openalex.org/W4211018206","https://openalex.org/W6673558080"],"related_works":["https://openalex.org/W1964958355","https://openalex.org/W3016244131","https://openalex.org/W2092763201","https://openalex.org/W2491375276","https://openalex.org/W3088073422","https://openalex.org/W2234867874","https://openalex.org/W4389055949","https://openalex.org/W369188865","https://openalex.org/W2158416088","https://openalex.org/W1976134470"],"abstract_inverted_index":{"A":[0],"breast":[1],"cancer":[2,81],"cell":[3,56],"detection":[4,26,87,142],"method":[5],"by":[6,46,54],"using":[7],"a":[8,23],"tilted":[9],"fiber":[10],"Bragg":[11],"gratings":[12],"(TFBGs)":[13],"coated":[14],"with":[15,34,59,95,104],"halloysite":[16],"nanotubes":[17],"(HNTs)":[18],"has":[19,30],"been":[20,31],"proposed":[21,127],"and":[22,107,139],"limit":[24],"of":[25,27,43,76,88,93,115,118,143],"10":[28],"cells/mL":[29],"experimental":[32],"achieved":[33],"good":[35],"reproducibility.":[36],"Experiments":[37],"have":[38],"shown":[39],"that":[40,53],"the":[41,62,73,77,86,91,116,119],"capture":[42,68],"MCF-7":[44],"cells":[45,70,82],"peristaltic":[47],"pump":[48],"is":[49,65],"much":[50],"higher":[51],"than":[52],"static":[55],"solution.":[57],"Compared":[58],"normal":[60],"cells,":[61,90],"HNTs":[63,78],"coating":[64],"able":[66],"to":[67],"tumor":[69,89],"better,":[71],"because":[72,114],"surface":[74],"morphology":[75],"can":[79],"make":[80],"adhere":[83],"well.":[84],"In":[85],"integration":[92],"TFBGs":[94],"microfluidic":[96],"channels":[97],"enables":[98],"precise":[99],"measurement":[100],"control":[101,113],"over":[102],"samples":[103],"sub-microliter":[105],"volumes":[106],"does":[108],"not":[109],"require":[110],"accurate":[111],"temperature":[112,120],"elimination":[117],"cross-sensitivity":[121],"inherent":[122],"in":[123,148],"TFBG":[124],"devices.":[125],"The":[126],"optical":[128],"fiber/microfluidic":[129],"biosensor":[130],"represents":[131],"an":[132],"appealing":[133],"solution":[134],"for":[135],"rapid,":[136],"low":[137,146],"consumption":[138],"highly":[140],"sensitive":[141],"analytes":[144],"at":[145],"concentrations":[147],"medicine":[149],"monitoring.":[150]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}