{"id":"https://openalex.org/W2519684648","doi":"https://doi.org/10.1109/hpcsim.2016.7568384","title":"Improved algorithm for mammary adipose microenvironment definition byl automated brown fat quantification","display_name":"Improved algorithm for mammary adipose microenvironment definition byl automated brown fat quantification","publication_year":2016,"publication_date":"2016-07-01","ids":{"openalex":"https://openalex.org/W2519684648","doi":"https://doi.org/10.1109/hpcsim.2016.7568384","mag":"2519684648"},"language":"en","primary_location":{"id":"doi:10.1109/hpcsim.2016.7568384","is_oa":false,"landing_page_url":"https://doi.org/10.1109/hpcsim.2016.7568384","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 International Conference on High Performance Computing & Simulation (HPCS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111764772","display_name":"Vesna Zeljkovi\u0107","orcid":null},"institutions":[{"id":"https://openalex.org/I33821262","display_name":"Lincoln University - Pennsylvania","ror":"https://ror.org/0521rfb23","country_code":"US","type":"education","lineage":["https://openalex.org/I33821262"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vesna Zeljkovic","raw_affiliation_strings":["School of Science and Technology Lincoln University PA, USA"],"affiliations":[{"raw_affiliation_string":"School of Science and Technology Lincoln University PA, USA","institution_ids":["https://openalex.org/I33821262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032850443","display_name":"Claude Tameze","orcid":null},"institutions":[{"id":"https://openalex.org/I33821262","display_name":"Lincoln University - Pennsylvania","ror":"https://ror.org/0521rfb23","country_code":"US","type":"education","lineage":["https://openalex.org/I33821262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claude Tameze","raw_affiliation_strings":["School of Science and Technology Lincoln University PA, USA"],"affiliations":[{"raw_affiliation_string":"School of Science and Technology Lincoln University PA, USA","institution_ids":["https://openalex.org/I33821262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033071732","display_name":"Ivana Vu\u010denik","orcid":null},"institutions":[{"id":"https://openalex.org/I59897056","display_name":"California State University, Long Beach","ror":"https://ror.org/0080fxk18","country_code":"US","type":"education","lineage":["https://openalex.org/I59897056"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivana Vucenik","raw_affiliation_strings":["Electrical Engineering Department California State University, Long Beach, CA, USA"],"affiliations":[{"raw_affiliation_string":"Electrical Engineering Department California State University, Long Beach, CA, USA","institution_ids":["https://openalex.org/I59897056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102900054","display_name":"Laundette P. Jones","orcid":"https://orcid.org/0000-0002-9614-1363"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laundette Jones","raw_affiliation_strings":["School of Medicine University of Maryland MD, USA"],"affiliations":[{"raw_affiliation_string":"School of Medicine University of Maryland MD, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086674022","display_name":"C. Druzgalski","orcid":null},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Druzgalski","raw_affiliation_strings":["School of Medicine University of Maryland MD, USA"],"affiliations":[{"raw_affiliation_string":"School of Medicine University of Maryland MD, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032492775","display_name":"Pedro Mayorga","orcid":"https://orcid.org/0000-0002-1889-6154"},"institutions":[{"id":"https://openalex.org/I3133460883","display_name":"Mexicali Institute of Technology","ror":"https://ror.org/03jfd4440","country_code":"MX","type":"education","lineage":["https://openalex.org/I3133460883"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Pedro Mayorga","raw_affiliation_strings":["Instituto Tecnol6gico de Mexicali (ITM), Mexicali B.C., M\u00e9xico"],"affiliations":[{"raw_affiliation_string":"Instituto Tecnol6gico de Mexicali (ITM), Mexicali B.C., M\u00e9xico","institution_ids":["https://openalex.org/I3133460883"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5111764772"],"corresponding_institution_ids":["https://openalex.org/I33821262"],"apc_list":null,"apc_paid":null,"fwci":0.9447,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.76776605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"87","issue":null,"first_page":"555","last_page":"561"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"Adipose tissue","score":0.9012085795402527},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"White adipose tissue","score":0.6915123462677002},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"Brown adipose tissue","score":0.6594229340553284},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"Thermogenesis","score":0.45658960938453674},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"Mammary gland","score":0.44182634353637695},{"id":"https://openalex.org/keywords/connective-tissue","display_name":"Connective tissue","score":0.43741557002067566},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4251285493373871},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3905589282512665},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.3636510968208313},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32657694816589355},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19138184189796448}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.9012085795402527},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.6915123462677002},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.6594229340553284},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.45658960938453674},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.44182634353637695},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.43741557002067566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4251285493373871},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3905589282512665},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3636510968208313},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32657694816589355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19138184189796448},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/hpcsim.2016.7568384","is_oa":false,"landing_page_url":"https://doi.org/10.1109/hpcsim.2016.7568384","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 International Conference on High Performance Computing & Simulation (HPCS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.6399999856948853}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1549695464","https://openalex.org/W1843349889","https://openalex.org/W1892385952","https://openalex.org/W1948169837","https://openalex.org/W1995388182","https://openalex.org/W2004750645","https://openalex.org/W2008150005","https://openalex.org/W2030139515","https://openalex.org/W2030954815","https://openalex.org/W2036956712","https://openalex.org/W2043536007","https://openalex.org/W2061138960","https://openalex.org/W2068673312","https://openalex.org/W2098847305","https://openalex.org/W2103970959","https://openalex.org/W2116010079","https://openalex.org/W2119063676","https://openalex.org/W2123371309","https://openalex.org/W2123518031","https://openalex.org/W2132358997","https://openalex.org/W2158572006","https://openalex.org/W2163951355","https://openalex.org/W2208785046","https://openalex.org/W2263757096","https://openalex.org/W2344242613","https://openalex.org/W2412849637","https://openalex.org/W2487352563","https://openalex.org/W7014780671"],"related_works":["https://openalex.org/W2059411416","https://openalex.org/W2406660090","https://openalex.org/W2415557033","https://openalex.org/W2763780577","https://openalex.org/W3047633609","https://openalex.org/W3029291832","https://openalex.org/W3134072345","https://openalex.org/W2416934161","https://openalex.org/W2167431561","https://openalex.org/W3146532088"],"abstract_inverted_index":{"Adipose":[0],"tissue,":[1,180],"known":[2],"also":[3],"as":[4,72],"fat,":[5,60],"is":[6,95,106,254],"a":[7,73,163,274],"loose":[8],"connective":[9],"tissue":[10,29,45,130,203,216,267],"that":[11,55,61,92,120,206,231],"fills":[12],"up":[13],"space":[14],"between":[15],"the":[16,31,36,132,138,146,175,182,186,226,261,266,281,284,291],"organs":[17],"and":[18,21,40,58,64,82,98,111,166,173,238,250,258,277],"provides":[19],"structural":[20],"metabolic":[22],"support.":[23],"The":[24,190,242],"classical":[25],"functions":[26],"of":[27,33,38,76,122,131,148,154,170,177,184,220,260,283,290,293],"adipose":[28,44,179,188,202,215],"are":[30,125],"storage":[32],"energy":[34],"in":[35,100,128,151,199,204,225,265,273],"form":[37],"triglycerides,":[39],"thermal":[41],"insulation.":[42],"Historically,":[43],"has":[46,89,245],"been":[47,90],"subdivided":[48],"into":[49],"two":[50,246],"main":[51],"types:":[52],"white":[53],"fat":[54,68,77,94,105,124,150,178,224,264,296],"stores":[56],"energy,":[57],"brown":[59,93,104,123,149,201,223,263,295],"induce":[62],"thermogenesis":[63],"produce":[65],"heat.":[66],"Brown":[67],"was":[69],"previously":[70],"regarded":[71],"special":[74],"type":[75],"relevant":[78],"only":[79],"for":[80],"newborns":[81],"hibernating":[83],"animals":[84],"defending":[85],"against":[86],"cold.":[87],"Recently":[88],"shown":[91],"physiologically":[96],"present":[97],"active":[99],"adult":[101],"humans.":[102],"However,":[103],"extremely":[107],"difficult":[108,114],"to":[109,115,137,144,195],"visualize":[110],"even":[112],"more":[113],"quantify.":[116],"We":[117,142,160,211],"have":[118],"found":[119],"levels":[121],"dramatically":[126],"increased":[127],"mammary":[129,155,187,209,228],"BRCA1":[133],"mutant":[134],"mice":[135],"compared":[136],"normal,":[139],"wild-type":[140],"mice.":[141,159],"attempted":[143],"quantify":[145],"amount":[147,292],"histological":[152],"sections":[153],"tissues":[156],"from":[157,280],"these":[158],"initially":[161],"presented":[162],"mathematical":[164],"model":[165],"intelligent":[167],"software":[168],"capable":[169,219],"automatically":[171],"detecting":[172,200,222],"quantifying":[174],"content":[176,301],"with":[181],"goal":[183],"defining":[185],"microenvironment.":[189],"proposed":[191,243],"algorithm":[192,218],"showed":[193],"itself":[194],"be":[196],"very":[197],"successful":[198],"images":[205,269],"contain":[207],"pure":[208],"tissue.":[210,285],"propose":[212],"here":[213],"improved":[214],"detection":[217,257],"successfully":[221],"whole":[227],"gland":[229],"image":[230],"contains":[232],"extra":[233],"information":[234],"like":[235],"arteries,":[236],"background":[237],"other":[239],"surrounding":[240],"elements.":[241],"method":[244],"fold":[247],"function:":[248],"visual":[249],"numerical.":[251],"Visual":[252],"function":[253,287],"expressed":[255],"through":[256],"indication":[259],"potential":[262],"microscopic":[268],"by":[270,297],"marking":[271],"it":[272,279],"different":[275],"color":[276],"distinguishing":[278],"rest":[282],"Numerical":[286],"enables":[288],"quantification":[289],"detected":[294],"calculating":[298],"its":[299],"numerical":[300],"equivalent.":[302]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}