{"id":"https://openalex.org/W2065284068","doi":"https://doi.org/10.1109/hpcsim.2012.6266997","title":"Simulation of the release and diffusion of neurotransmitters in neuronal synapses: Analysis and modelling","display_name":"Simulation of the release and diffusion of neurotransmitters in neuronal synapses: Analysis and modelling","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2065284068","doi":"https://doi.org/10.1109/hpcsim.2012.6266997","mag":"2065284068"},"language":"en","primary_location":{"id":"doi:10.1109/hpcsim.2012.6266997","is_oa":false,"landing_page_url":"https://doi.org/10.1109/hpcsim.2012.6266997","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 International Conference on High Performance Computing & Simulation (HPCS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064989464","display_name":"Elena Gomez Barroso","orcid":null},"institutions":[{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Elena Gomez Barroso","raw_affiliation_strings":["Departamento de Arquitectura y Tecnolog\u00eda de Sistemas Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain","Departamento de Arquitectura y Tecnologia de Sistemas Inform\u00e1ticos, Universidad Politecnica de Madrid, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Departamento de Arquitectura y Tecnolog\u00eda de Sistemas Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]},{"raw_affiliation_string":"Departamento de Arquitectura y Tecnologia de Sistemas Inform\u00e1ticos, Universidad Politecnica de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051267702","display_name":"Jose Maria Pe\u00f1a Sanchez","orcid":null},"institutions":[{"id":"https://openalex.org/I4210139293","display_name":"Comunidad de Madrid","ror":"https://ror.org/040scgh75","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Maria Pena Sanchez","raw_affiliation_strings":["Universidad Politecnica de Madrid, Madrid, Comunidad de Madrid, ES","Departamento de Arquitectura y Tecnologia de Sistemas Inform\u00e1ticos, Universidad Politecnica de Madrid, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Universidad Politecnica de Madrid, Madrid, Comunidad de Madrid, ES","institution_ids":["https://openalex.org/I88060688","https://openalex.org/I4210139293"]},{"raw_affiliation_string":"Departamento de Arquitectura y Tecnologia de Sistemas Inform\u00e1ticos, Universidad Politecnica de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066562330","display_name":"\u00c1ngel Merch\u00e1n-P\u00e9rez","orcid":"https://orcid.org/0000-0002-7228-5821"},"institutions":[{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]},{"id":"https://openalex.org/I4210139293","display_name":"Comunidad de Madrid","ror":"https://ror.org/040scgh75","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Angel Merchan Perez","raw_affiliation_strings":["Universidad Politecnica de Madrid, Madrid, Comunidad de Madrid, ES","Departamento de Arquitectura y Tecnologia de Sistemas Inform\u00e1ticos, Universidad Politecnica de Madrid, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Universidad Politecnica de Madrid, Madrid, Comunidad de Madrid, ES","institution_ids":["https://openalex.org/I88060688","https://openalex.org/I4210139293"]},{"raw_affiliation_string":"Departamento de Arquitectura y Tecnologia de Sistemas Inform\u00e1ticos, Universidad Politecnica de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064989464"],"corresponding_institution_ids":["https://openalex.org/I88060688"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0980025,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":"696","last_page":"698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotransmitter-receptor","display_name":"Neurotransmitter receptor","score":0.6653289794921875},{"id":"https://openalex.org/keywords/neurotransmission","display_name":"Neurotransmission","score":0.6534653902053833},{"id":"https://openalex.org/keywords/neurotransmitter","display_name":"Neurotransmitter","score":0.6454475522041321},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.6136182546615601},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5652928948402405},{"id":"https://openalex.org/keywords/postsynaptic-potential","display_name":"Postsynaptic potential","score":0.5406569838523865},{"id":"https://openalex.org/keywords/synaptic-cleft","display_name":"Synaptic cleft","score":0.5404812097549438},{"id":"https://openalex.org/keywords/glutamate-receptor","display_name":"Glutamate receptor","score":0.4641132950782776},{"id":"https://openalex.org/keywords/silent-synapse","display_name":"Silent synapse","score":0.45325028896331787},{"id":"https://openalex.org/keywords/ampa-receptor","display_name":"AMPA receptor","score":0.4521992802619934},{"id":"https://openalex.org/keywords/postsynaptic-density","display_name":"Postsynaptic density","score":0.42824602127075195},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3482162356376648},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3461803197860718},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3401631712913513},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.26220741868019104},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2540245056152344},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.21987292170524597},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.05474573373794556}],"concepts":[{"id":"https://openalex.org/C156927020","wikidata":"https://www.wikidata.org/wiki/Q1187783","display_name":"Neurotransmitter receptor","level":3,"score":0.6653289794921875},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.6534653902053833},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.6454475522041321},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.6136182546615601},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5652928948402405},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.5406569838523865},{"id":"https://openalex.org/C2993285035","wikidata":"https://www.wikidata.org/wiki/Q2643251","display_name":"Synaptic cleft","level":4,"score":0.5404812097549438},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4641132950782776},{"id":"https://openalex.org/C154559735","wikidata":"https://www.wikidata.org/wiki/Q7514768","display_name":"Silent synapse","level":5,"score":0.45325028896331787},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.4521992802619934},{"id":"https://openalex.org/C187541742","wikidata":"https://www.wikidata.org/wiki/Q4374336","display_name":"Postsynaptic density","level":4,"score":0.42824602127075195},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3482162356376648},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3461803197860718},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3401631712913513},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26220741868019104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2540245056152344},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.21987292170524597},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05474573373794556},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/hpcsim.2012.6266997","is_oa":false,"landing_page_url":"https://doi.org/10.1109/hpcsim.2012.6266997","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 International Conference on High Performance Computing & Simulation (HPCS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2009759632","https://openalex.org/W2011139878","https://openalex.org/W2044514703","https://openalex.org/W2049437000","https://openalex.org/W2074540503","https://openalex.org/W2082969312","https://openalex.org/W2085323762","https://openalex.org/W2090584164","https://openalex.org/W2126033464","https://openalex.org/W2147084397"],"related_works":["https://openalex.org/W4256018609","https://openalex.org/W1592516385","https://openalex.org/W2044761516","https://openalex.org/W3189535008","https://openalex.org/W2044031472","https://openalex.org/W2060732248","https://openalex.org/W2026464117","https://openalex.org/W2068175467","https://openalex.org/W2161458381","https://openalex.org/W2342290876"],"abstract_inverted_index":{"Chemical":[0],"synaptic":[1,37,67,97],"transmisssion":[2],"involves":[3],"the":[4,12,22,36,49,62,89,92,96,117],"release":[5],"of":[6,35,52,85,91,108],"a":[7,71,82],"neurotransmitter":[8,53,118],"that":[9,69,87],"diffuses":[10],"in":[11,95],"extracellular":[13],"space":[14],"and":[15,55,116],"interacts":[16],"with":[17,58],"specific":[18],"receptors":[19,113],"located":[20],"on":[21,104],"postsynaptic":[23],"membrane.":[24],"Computer":[25],"simulation":[26],"approaches":[27],"provide":[28],"fundamental":[29],"tools":[30],"for":[31],"exploring":[32],"various":[33],"aspects":[34],"transmission":[38],"under":[39],"different":[40],"conditions.":[41],"In":[42],"particular,":[43],"Monte":[44],"Carlo":[45],"methods":[46],"can":[47],"track":[48],"stochastic":[50],"movements":[51],"molecules":[54],"their":[56],"interactions":[57],"other":[59],"discrete":[60],"molecules,":[61],"receptors.":[63],"We":[64,99],"have":[65,100],"developed":[66],"models":[68,107],"had":[70,81],"simple":[72],"geometry":[73],"as":[74,76],"far":[75],"shape":[77],"is":[78,120],"concerned,":[79],"but":[80],"variable":[83],"set":[84],"parameters":[86],"specified":[88],"dimensions":[90],"structures":[93],"involved":[94,119],"junction.":[98],"analyzed":[101],"simulations":[102],"based":[103],"these":[105],"idealized":[106],"excitatory":[109],"synapses":[110],"where":[111],"AMPA":[112],"are":[114],"present":[115],"glutamate.":[121]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}