{"id":"https://openalex.org/W2143479365","doi":"https://doi.org/10.1109/hpcsim.2011.5999898","title":"A noise reducing sampling approach for uncovering critical properties in large scale biological networks","display_name":"A noise reducing sampling approach for uncovering critical properties in large scale biological networks","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W2143479365","doi":"https://doi.org/10.1109/hpcsim.2011.5999898","mag":"2143479365"},"language":"en","primary_location":{"id":"doi:10.1109/hpcsim.2011.5999898","is_oa":false,"landing_page_url":"https://doi.org/10.1109/hpcsim.2011.5999898","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 International Conference on High Performance Computing &amp; Simulation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010866654","display_name":"Kanimathi Duraisamy","orcid":null},"institutions":[{"id":"https://openalex.org/I122266389","display_name":"University of Nebraska at Omaha","ror":"https://ror.org/04yrkc140","country_code":"US","type":"education","lineage":["https://openalex.org/I122266389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Duraisamy","raw_affiliation_strings":["College of Information Science and Technology, University of Nebraska Omaha, Omaha, NE, USA","College of Information Science and Technology, University of Nebraska at Omaha, Omaha NE 68182, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"College of Information Science and Technology, University of Nebraska Omaha, Omaha, NE, USA","institution_ids":["https://openalex.org/I122266389"]},{"raw_affiliation_string":"College of Information Science and Technology, University of Nebraska at Omaha, Omaha NE 68182, USA#TAB#","institution_ids":["https://openalex.org/I122266389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005196882","display_name":"Kathryn Dempsey","orcid":null},"institutions":[{"id":"https://openalex.org/I122266389","display_name":"University of Nebraska at Omaha","ror":"https://ror.org/04yrkc140","country_code":"US","type":"education","lineage":["https://openalex.org/I122266389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Dempsey","raw_affiliation_strings":["College of Information Science and Technology, University of Nebraska Omaha, Omaha, NE, USA","College of Information Science and Technology, University of Nebraska at Omaha, Omaha NE 68182, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"College of Information Science and Technology, University of Nebraska Omaha, Omaha, NE, USA","institution_ids":["https://openalex.org/I122266389"]},{"raw_affiliation_string":"College of Information Science and Technology, University of Nebraska at Omaha, Omaha NE 68182, USA#TAB#","institution_ids":["https://openalex.org/I122266389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047703641","display_name":"Hesham Ali","orcid":"https://orcid.org/0000-0001-6675-7987"},"institutions":[{"id":"https://openalex.org/I122266389","display_name":"University of Nebraska at Omaha","ror":"https://ror.org/04yrkc140","country_code":"US","type":"education","lineage":["https://openalex.org/I122266389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Ali","raw_affiliation_strings":["College of Information Science and Technology, University of Nebraska Omaha, Omaha, NE, USA","College of Information Science and Technology, University of Nebraska at Omaha, Omaha NE 68182, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"College of Information Science and Technology, University of Nebraska Omaha, Omaha, NE, USA","institution_ids":["https://openalex.org/I122266389"]},{"raw_affiliation_string":"College of Information Science and Technology, University of Nebraska at Omaha, Omaha NE 68182, USA#TAB#","institution_ids":["https://openalex.org/I122266389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064623347","display_name":"Sanjukta Bhowmick","orcid":"https://orcid.org/0000-0001-8550-5371"},"institutions":[{"id":"https://openalex.org/I122266389","display_name":"University of Nebraska at Omaha","ror":"https://ror.org/04yrkc140","country_code":"US","type":"education","lineage":["https://openalex.org/I122266389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Bhowmick","raw_affiliation_strings":["College of Information Science and Technology, University of Nebraska Omaha, Omaha, NE, USA","College of Information Science and Technology, University of Nebraska at Omaha, Omaha NE 68182, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"College of Information Science and Technology, University of Nebraska Omaha, Omaha, NE, USA","institution_ids":["https://openalex.org/I122266389"]},{"raw_affiliation_string":"College of Information Science and Technology, University of Nebraska at Omaha, Omaha NE 68182, USA#TAB#","institution_ids":["https://openalex.org/I122266389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010866654"],"corresponding_institution_ids":["https://openalex.org/I122266389"],"apc_list":null,"apc_paid":null,"fwci":1.3029,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.79670459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"721","last_page":"728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10064","display_name":"Complex Network Analysis Techniques","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bottleneck","display_name":"Bottleneck","score":0.730069100856781},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6889756917953491},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.6509048938751221},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5326169729232788},{"id":"https://openalex.org/keywords/scale-free-network","display_name":"Scale-free network","score":0.49530258774757385},{"id":"https://openalex.org/keywords/degree-distribution","display_name":"Degree distribution","score":0.48847830295562744},{"id":"https://openalex.org/keywords/network-motif","display_name":"Network motif","score":0.48408663272857666},{"id":"https://openalex.org/keywords/sampling","display_name":"Sampling (signal processing)","score":0.4837932288646698},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.47966670989990234},{"id":"https://openalex.org/keywords/complex-network","display_name":"Complex network","score":0.477166086435318},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.4668223261833191},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.44154366850852966},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.43869078159332275},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4233185648918152},{"id":"https://openalex.org/keywords/clustering-coefficient","display_name":"Clustering coefficient","score":0.41008615493774414},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.2336464524269104},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.19317281246185303},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.1751391589641571},{"id":"https://openalex.org/keywords/filter","display_name":"Filter (signal processing)","score":0.16496002674102783},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13586938381195068},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13021615147590637}],"concepts":[{"id":"https://openalex.org/C2780513914","wikidata":"https://www.wikidata.org/wiki/Q18210350","display_name":"Bottleneck","level":2,"score":0.730069100856781},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6889756917953491},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.6509048938751221},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5326169729232788},{"id":"https://openalex.org/C25580894","wikidata":"https://www.wikidata.org/wiki/Q1071058","display_name":"Scale-free network","level":3,"score":0.49530258774757385},{"id":"https://openalex.org/C87414783","wikidata":"https://www.wikidata.org/wiki/Q1002603","display_name":"Degree distribution","level":3,"score":0.48847830295562744},{"id":"https://openalex.org/C60723933","wikidata":"https://www.wikidata.org/wiki/Q7001080","display_name":"Network motif","level":3,"score":0.48408663272857666},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.4837932288646698},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.47966670989990234},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.477166086435318},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.4668223261833191},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.44154366850852966},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43869078159332275},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4233185648918152},{"id":"https://openalex.org/C22047676","wikidata":"https://www.wikidata.org/wiki/Q898680","display_name":"Clustering coefficient","level":3,"score":0.41008615493774414},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.2336464524269104},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.19317281246185303},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.1751391589641571},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.16496002674102783},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13586938381195068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13021615147590637},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/hpcsim.2011.5999898","is_oa":false,"landing_page_url":"https://doi.org/10.1109/hpcsim.2011.5999898","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 International Conference on High Performance Computing &amp; Simulation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions","score":0.4300000071525574}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1504510381","https://openalex.org/W1596345407","https://openalex.org/W2017390791","https://openalex.org/W2072679355","https://openalex.org/W2107084703","https://openalex.org/W2111708605","https://openalex.org/W2130790725","https://openalex.org/W2142720308","https://openalex.org/W2146008005","https://openalex.org/W2153908768","https://openalex.org/W2163480486","https://openalex.org/W2168380307","https://openalex.org/W2168546553","https://openalex.org/W4230450987","https://openalex.org/W6654682825"],"related_works":["https://openalex.org/W1984885659","https://openalex.org/W3135574635","https://openalex.org/W2617506565","https://openalex.org/W2036354372","https://openalex.org/W2890733292","https://openalex.org/W2361239511","https://openalex.org/W3104073075","https://openalex.org/W2132666267","https://openalex.org/W2068804411","https://openalex.org/W2951066103"],"abstract_inverted_index":{"A":[0],"correlation":[1,40,67,81],"network":[2,49,76,122,127,137,147,159,188],"is":[3,102,123],"a":[4,95,107,124,144],"graph-based":[5],"representation":[6],"of":[7,19,27,29,53,56,158,179,186],"relationships":[8],"among":[9],"genes":[10,73],"or":[11],"gene":[12,58],"products,":[13],"such":[14,37],"as":[15,38,143],"proteins.":[16],"The":[17],"advent":[18],"high-throughput":[20],"bioinformatics":[21],"has":[22],"resulted":[23],"in":[24,34,47,74,86,120,161],"the":[25,39,66,70,75,79,121,177,184,206,226],"generation":[26],"volumes":[28],"data":[30],"that":[31,99,153,193,202,220],"require":[32],"sophisticated":[33],"silico":[35],"models,":[36],"network,":[41],"for":[42,126,146],"in-depth":[43],"analysis.":[44],"Each":[45],"element":[46],"our":[48,169,180],"represents":[50],"expression":[51],"levels":[52],"multiple":[54],"samples":[55],"one":[57],"and":[59,104,117,139,182],"an":[60],"edge":[61],"connecting":[62],"two":[63,71],"nodes":[64],"reflects":[65],"level":[68],"between":[69],"corresponding":[72],"according":[77],"to":[78,92,94,106,114,171],"Pearson":[80],"coefficient.":[82],"Biological":[83],"networks":[84],"made":[85],"this":[87,165],"manner":[88],"are":[89,203],"generally":[90],"found":[91],"adhere":[93],"scale-free":[96],"structural":[97],"nature,":[98],"is,":[100],"it":[101],"modular":[103],"adheres":[105],"power-law":[108],"degree":[109],"distribution.":[110],"Filtering":[111],"these":[112],"structures":[113],"remove":[115],"noise":[116,212],"coincidental":[118],"edges":[119],"necessity":[125],"theorists":[128],"because":[129],"unfortunately,":[130],"when":[131],"examining":[132],"entire":[133],"genomes":[134],"at":[135],"once,":[136],"size":[138],"complexity":[140],"can":[141,213],"act":[142],"bottleneck":[145],"manageability.":[148],"Our":[149,190],"previous":[150],"work":[151],"demonstrated":[152],"chordal":[154,194],"graph":[155,195],"based":[156,196],"sampling":[157,197],"results":[160,178,191],"viable":[162],"models.":[163],"In":[164],"paper,":[166],"we":[167],"extend":[168],"research":[170],"investigate":[172],"how":[173],"different":[174],"orderings":[175],"affect":[176],"sampling,":[181],"maintain":[183],"viability":[185],"resulting":[187],"structures.":[189],"show":[192],"not":[198,223],"only":[199],"conserves":[200],"clusters":[201,219],"present":[204],"within":[205],"original":[207,227],"networks,":[208],"but":[209],"by":[210],"reducing":[211],"also":[214],"help":[215],"uncover":[216],"additional":[217],"functional":[218],"were":[221],"previously":[222],"obtainable":[224],"from":[225],"network.":[228]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
