{"id":"https://openalex.org/W2554713541","doi":"https://doi.org/10.1109/hldvt.2016.7748271","title":"High-level modeling and verification of cellular signaling","display_name":"High-level modeling and verification of cellular signaling","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2554713541","doi":"https://doi.org/10.1109/hldvt.2016.7748271","mag":"2554713541"},"language":"en","primary_location":{"id":"doi:10.1109/hldvt.2016.7748271","is_oa":false,"landing_page_url":"https://doi.org/10.1109/hldvt.2016.7748271","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International High Level Design Validation and Test Workshop (HLDVT)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017141796","display_name":"Nata\u0161a Mi\u0161kov-\u017divanov","orcid":"https://orcid.org/0000-0003-1110-3403"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Natasa Miskov-Zivanov","raw_affiliation_strings":["University of Pittsburgh Electrical and Computer Engineering Bioengineering Computational and Systems Biology Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Electrical and Computer Engineering Bioengineering Computational and Systems Biology Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054022139","display_name":"Paolo Zuliani","orcid":"https://orcid.org/0000-0001-6033-5919"},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paolo Zuliani","raw_affiliation_strings":["Newcastle University Computer Science Newcastle upon Tyne, UK"],"affiliations":[{"raw_affiliation_string":"Newcastle University Computer Science Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052617216","display_name":"Qinsi Wang","orcid":"https://orcid.org/0000-0002-5868-9686"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinsi Wang","raw_affiliation_strings":["Carnegie Mellon University Computer Science Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University Computer Science Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105356861","display_name":"Edmund M. Clarke","orcid":null},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmund M. Clarke","raw_affiliation_strings":["Carnegie Mellon University Computer Science Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University Computer Science Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020336186","display_name":"James R. Faeder","orcid":"https://orcid.org/0000-0001-8127-609X"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. Faeder","raw_affiliation_strings":["University of Pittsburgh Computational and Systems Biology Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Computational and Systems Biology Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017141796"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":0.5002,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.71483038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5688","issue":null,"first_page":"162","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10142","display_name":"Formal Methods in Verification","score":0.9751999974250793,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5982296466827393}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5982296466827393}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/hldvt.2016.7748271","is_oa":false,"landing_page_url":"https://doi.org/10.1109/hldvt.2016.7748271","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International High Level Design Validation and Test Workshop (HLDVT)","raw_type":"proceedings-article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1681070","is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1681070","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1489725951","https://openalex.org/W1569248486","https://openalex.org/W2103012681","https://openalex.org/W2103723044","https://openalex.org/W2106030214","https://openalex.org/W2124810679","https://openalex.org/W2132216539","https://openalex.org/W2165161585","https://openalex.org/W2167770337"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2093578348","https://openalex.org/W2376932109","https://openalex.org/W2382290278","https://openalex.org/W2766271392","https://openalex.org/W2350741829","https://openalex.org/W3004735627"],"abstract_inverted_index":{"We":[0,109],"use":[1],"computational":[2],"modeling":[3],"and":[4,28,45,101,117,130],"formal":[5],"analysis":[6,60,127],"techniques":[7],"to":[8,104],"study":[9],"temporal":[10,32],"behavior":[11],"of":[12,17,66,90,115,128],"a":[13,63,112],"discrete":[14],"logical":[15],"model":[16,24,37,41,53,83],"the":[18,40,74,93],"na\u00efve":[19],"T":[20],"cell":[21],"differentiation.":[22],"The":[23,79],"is":[25],"analyzed":[26],"formally":[27],"automatically":[29],"by":[30,61,77],"performing":[31],"logic":[33],"queries":[34],"via":[35],"statistical":[36],"checking.":[38],"While":[39],"can":[42],"be":[43,98],"verified":[44],"then":[46],"further":[47],"explored":[48],"using":[49,82],"Monte":[50],"Carlo":[51],"simulations,":[52],"checking":[54,84],"allows":[55],"for":[56],"much":[57,70],"more":[58],"efficient":[59],"testing":[62],"large":[64,113],"set":[65],"system":[67],"properties,":[68,116],"with":[69],"smaller":[71],"runtime":[72],"than":[73],"one":[75],"required":[76],"simulations.":[78],"results":[80],"obtained":[81],"provide":[85],"details":[86],"about":[87],"relative":[88],"timing":[89],"events":[91],"in":[92],"system,":[94],"which":[95],"would":[96],"otherwise":[97],"very":[99],"cumbersome":[100],"time":[102],"consuming":[103],"obtain":[105],"through":[106],"simulations":[107],"only.":[108],"efficiently":[110],"test":[111],"number":[114],"confirm":[118],"or":[119],"reject":[120],"hypotheses":[121],"that":[122],"were":[123],"drawn":[124],"from":[125],"previous":[126],"experimental":[129],"simulation":[131],"data.":[132]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-11-30T00:00:00"}
