{"id":"https://openalex.org/W2115270453","doi":"https://doi.org/10.1109/grc.2006.1635910","title":"Genotype susceptibility and integrated risk factors for complex diseases","display_name":"Genotype susceptibility and integrated risk factors for complex diseases","publication_year":2006,"publication_date":"2006-06-08","ids":{"openalex":"https://openalex.org/W2115270453","doi":"https://doi.org/10.1109/grc.2006.1635910","mag":"2115270453"},"language":"en","primary_location":{"id":"doi:10.1109/grc.2006.1635910","is_oa":false,"landing_page_url":"https://doi.org/10.1109/grc.2006.1635910","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2006 IEEE International Conference on Granular Computing","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086898367","display_name":"Weidong Mao","orcid":null},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Weidong Mao","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056793831","display_name":"Dumitru Brinza","orcid":null},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Brinza","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049321641","display_name":"Nisar Hundewale","orcid":"https://orcid.org/0000-0001-9751-4304"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Hundewale","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027336137","display_name":"S. Gremalschi","orcid":null},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Gremalschi","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072751459","display_name":"Alex Zelikovsky","orcid":"https://orcid.org/0000-0003-4424-4691"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Zelikovsky","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I181565077"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086898367"],"corresponding_institution_ids":["https://openalex.org/I181565077"],"apc_list":null,"apc_paid":null,"fwci":2.1373,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.87585106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"22","issue":null,"first_page":"754","last_page":"757"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.6843324303627014},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.6604519486427307},{"id":"https://openalex.org/keywords/genotyping","display_name":"Genotyping","score":0.6131600737571716},{"id":"https://openalex.org/keywords/crohns-disease","display_name":"Crohn's disease","score":0.49024254083633423},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"Autoimmune disease","score":0.46480026841163635},{"id":"https://openalex.org/keywords/risk-factor","display_name":"Risk factor","score":0.45981794595718384},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3837917447090149},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3533608913421631},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.22260770201683044},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1926342248916626},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1905757188796997},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09586971998214722}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6843324303627014},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6604519486427307},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6131600737571716},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.49024254083633423},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.46480026841163635},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.45981794595718384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3837917447090149},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3533608913421631},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22260770201683044},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1926342248916626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1905757188796997},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09586971998214722}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/grc.2006.1635910","is_oa":false,"landing_page_url":"https://doi.org/10.1109/grc.2006.1635910","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2006 IEEE International Conference on Granular Computing","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.133.2104","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.133.2104","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cs.ucsd.edu/~dbrinza/cv/pub/brinza_disease.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4399999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1508985588","https://openalex.org/W1519521580","https://openalex.org/W1571957788","https://openalex.org/W1583476286","https://openalex.org/W1975676017","https://openalex.org/W1978136801","https://openalex.org/W1985849948","https://openalex.org/W2092450585","https://openalex.org/W2107349212","https://openalex.org/W2122227569","https://openalex.org/W2126009609","https://openalex.org/W2145838157","https://openalex.org/W2152664025","https://openalex.org/W2157249267","https://openalex.org/W6681471764"],"related_works":["https://openalex.org/W2378369506","https://openalex.org/W2353370357","https://openalex.org/W2806032235","https://openalex.org/W2755824586","https://openalex.org/W4212927541","https://openalex.org/W2044259093","https://openalex.org/W2377518790","https://openalex.org/W2394359576","https://openalex.org/W2463477745","https://openalex.org/W2349105149"],"abstract_inverted_index":{"Abstract":[0],"\u2014":[1,142],"Recent":[2],"improvements":[3],"in":[4],"the":[5,34,107,125],"accessibility":[6],"of":[7,15,27,66,80,124],"highthroughput":[8],"genotyping":[9],"have":[10,44],"brought":[11],"a":[12],"great":[13],"deal":[14],"attention":[16],"to":[17,32,47,61,94],"disease":[18,54,114,134],"association":[19],"and":[20,55,89,92,115,135],"susceptibility":[21,36,60,81],"studies.":[22],"This":[23],"paper":[24],"explores":[25],"possibility":[26],"applying":[28],"discrete":[29],"optimization":[30],"methods":[31,43],"predict":[33],"genotype":[35,50],"for":[37,58,112,118,132,137],"complex":[38,143],"disease.":[39],"The":[40,64,78,121],"proposed":[41],"combinatorial":[42],"been":[45,85],"applied":[46],"publicly":[48],"available":[49],"data":[51],"on":[52,99],"Crohn\u2019s":[53,113,133],"autoimmune":[56,119,138],"disorders":[57],"predicting":[59],"these":[62],"diseases.":[63],"result":[65],"predicted":[67],"status":[68],"can":[69],"be":[70,95],"also":[71],"viewed":[72],"as":[73],"an":[74],"integrated":[75,127],"risk":[76,122,128,148],"factor.":[77],"quality":[79],"prediction":[82,103,108,145],"algorithm":[83],"has":[84],"assessed":[86],"using":[87],"leave-one-out":[88],"leave-many-out":[90],"tests":[91],"shown":[93],"statistically":[96],"significant":[97],"based":[98],"randomization":[100],"tests.The":[101],"best":[102],"rate":[104,123],"achieved":[105],"by":[106],"algorithms":[109],"is":[110,130],"69.5%":[111],"63.9":[116],"%":[117],"disorder.":[120,139],"corresponding":[126],"factor":[129],"2.23":[131],"1.73":[136],"Index":[140],"Terms":[141],"diseases,":[144],"methods,":[146],"susceptibility,":[147],"factors,":[149],"genotypes.":[150],"I.":[151]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}