{"id":"https://openalex.org/W3123538971","doi":"https://doi.org/10.1109/globecom42002.2020.9322529","title":"Growing Bio-nanomachine Networks: Application to Malignant Tumor Evolution and Progression","display_name":"Growing Bio-nanomachine Networks: Application to Malignant Tumor Evolution and Progression","publication_year":2020,"publication_date":"2020-12-01","ids":{"openalex":"https://openalex.org/W3123538971","doi":"https://doi.org/10.1109/globecom42002.2020.9322529","mag":"3123538971"},"language":"en","primary_location":{"id":"doi:10.1109/globecom42002.2020.9322529","is_oa":false,"landing_page_url":"https://doi.org/10.1109/globecom42002.2020.9322529","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GLOBECOM 2020 - 2020 IEEE Global Communications Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005546566","display_name":"Tadashi Nakano","orcid":"https://orcid.org/0000-0003-3354-8964"},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Nakano","raw_affiliation_strings":["Institute for Datability Science, Osaka University,Japan","Institute for Datability Science, Osaka University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Datability Science, Osaka University,Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Institute for Datability Science, Osaka University, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076876649","display_name":"Yutaka Okaie","orcid":"https://orcid.org/0000-0002-1273-594X"},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Okaie","raw_affiliation_strings":["Institute for Datability Science, Osaka University,Japan","Institute for Datability Science, Osaka University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Datability Science, Osaka University,Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Institute for Datability Science, Osaka University, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065661236","display_name":"Nikolaos Dietis","orcid":null},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Nikolaos Dietis","raw_affiliation_strings":["Medical School, University of Cyprus,Cyprus","Medical School, University of Cyprus, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, University of Cyprus,Cyprus","institution_ids":["https://openalex.org/I34771391"]},{"raw_affiliation_string":"Medical School, University of Cyprus, Cyprus","institution_ids":["https://openalex.org/I34771391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024638497","display_name":"Andreani D. Odysseos","orcid":"https://orcid.org/0000-0002-0442-2898"},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Andreani D. Odysseos","raw_affiliation_strings":["Translational Nanomedicine and Nanobiotechnology, EPOS-IASIS, R&D and University of Cyprus,Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Nanomedicine and Nanobiotechnology, EPOS-IASIS, R&D and University of Cyprus,Cyprus","institution_ids":["https://openalex.org/I34771391"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5228,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.62698701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9782999753952026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5684064626693726},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5128958225250244},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3680225610733032},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13507983088493347},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08033466339111328}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5684064626693726},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5128958225250244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3680225610733032},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13507983088493347},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08033466339111328}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/globecom42002.2020.9322529","is_oa":false,"landing_page_url":"https://doi.org/10.1109/globecom42002.2020.9322529","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GLOBECOM 2020 - 2020 IEEE Global Communications Conference","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1007645884","display_name":null,"funder_award_id":"JP17H00733","funder_id":"https://openalex.org/F4320320212","funder_display_name":"Japan Society for the Promotion of Science London"},{"id":"https://openalex.org/G6044318940","display_name":"Next-generation theranostics of brain pathologies with autonomous externally controllable nanonetworks: a trans-disciplinary approach with bio-nanodevice interfaces","funder_award_id":"828837","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320212","display_name":"Japan Society for the Promotion of Science London","ror":"https://ror.org/02m7axw05"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1971593855","https://openalex.org/W2004471993","https://openalex.org/W2018036523","https://openalex.org/W2051588629","https://openalex.org/W2076162901","https://openalex.org/W2102085111","https://openalex.org/W2118044926","https://openalex.org/W2124793236","https://openalex.org/W2152998293","https://openalex.org/W2169061810","https://openalex.org/W2319926262","https://openalex.org/W2525509291","https://openalex.org/W2555709803","https://openalex.org/W2966374347","https://openalex.org/W4211246626"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189"],"abstract_inverted_index":{"Networks":[0],"of":[1,20,29,45,54,57,66,97,102,126],"bio-nanomachines":[2,58],"that":[3],"communicate":[4],"through":[5],"molecular":[6],"communication":[7],"are":[8],"expected":[9],"to":[10,93,123],"perform":[11],"complex":[12],"functionalities":[13],"within":[14,33,69],"biological":[15],"systems.":[16],"The":[17],"natural":[18],"history":[19],"malignant":[21,67,112],"tumors":[22],"can":[23,121],"be":[24],"defined":[25],"by":[26,75,110],"the":[27,64,95,108],"evolution":[28,128],"growing":[30],"bio-nanomachine":[31,98,115],"networks":[32,99,116],"an":[34],"interplay":[35],"between":[36],"proliferation":[37],"or":[38,80],"self-renewal":[39],"(Grow)":[40],"and":[41,78,82,104,117,129,131],"invasion":[42],"(Go)":[43],"potential":[44],"mutually":[46],"exclusive":[47],"phenotypes.":[48],"Herein":[49],"we":[50],"present":[51],"a":[52],"model":[53,86],"two":[55],"populations":[56],"representing":[59],"distinct":[60],"phenotypes":[61],"propagating":[62],"throughout":[63],"progression":[65,130],"gliomas":[68],"spatiotemporally":[70],"evolving":[71],"bionanomachine":[72],"networks,":[73],"driven":[74],"either":[76],"attractive":[77],"linkforming":[79],"repulsive":[81],"cluster-forming":[83],"forces.":[84],"This":[85],"is":[87],"further":[88],"applied":[89],"in":[90,100],"computer":[91],"simulations":[92],"examine":[94],"growth":[96],"terms":[101],"size":[103],"network":[105,119],"connectivity.":[106],"Understanding":[107],"mechanisms":[109,125],"which":[111],"cells":[113],"form":[114],"controlling":[118],"connectivity":[120],"contribute":[122],"deciphering":[124],"tumor":[127],"provide":[132],"new":[133],"nanonetwork-based":[134],"therapeutic":[135],"approaches.":[136]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-22T08:00:12.763002","created_date":"2025-10-10T00:00:00"}