{"id":"https://openalex.org/W2009614353","doi":"https://doi.org/10.1109/globalsip.2014.7032343","title":"Predicting age at loss of ambulation in Duchenne muscular dystrophy with deep phenotypic measures","display_name":"Predicting age at loss of ambulation in Duchenne muscular dystrophy with deep phenotypic measures","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2009614353","doi":"https://doi.org/10.1109/globalsip.2014.7032343","mag":"2009614353"},"language":"en","primary_location":{"id":"doi:10.1109/globalsip.2014.7032343","is_oa":false,"landing_page_url":"https://doi.org/10.1109/globalsip.2014.7032343","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE Global Conference on Signal and Information Processing (GlobalSIP)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040372961","display_name":"Yinxue Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yinxue Wang","raw_affiliation_strings":["Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA","Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057773685","display_name":"Luca Bello","orcid":"https://orcid.org/0000-0002-3075-6525"},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luca Bello","raw_affiliation_strings":["Research Center for Genetic Medicine, Children's National Medical Center, Washington DC","Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Genetic Medicine, Children's National Medical Center, Washington DC","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100372002","display_name":"Yue Wang","orcid":"https://orcid.org/0000-0002-1788-1102"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA","Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071163954","display_name":"Craig M. McDonald","orcid":"https://orcid.org/0000-0002-8779-3220"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig M. McDonald","raw_affiliation_strings":["Dept. of Physical Medicine & Rehabilitation, University of California, Davis, Sacramento, CA","Dept. of Physical Medicine & Rehabilitation, School of Medicine, University of California, Davis, Sacramento, CA 95817"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Physical Medicine & Rehabilitation, University of California, Davis, Sacramento, CA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Dept. of Physical Medicine & Rehabilitation, School of Medicine, University of California, Davis, Sacramento, CA 95817","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086088688","display_name":"Eric P. Hoffman","orcid":"https://orcid.org/0000-0001-6470-5139"},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric P. Hoffman","raw_affiliation_strings":["Research Center for Genetic Medicine, Children's National Medical Center, Washington DC","Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Genetic Medicine, Children's National Medical Center, Washington DC","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076006520","display_name":"Guoqiang Yu","orcid":"https://orcid.org/0000-0002-6743-7413"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoqiang Yu","raw_affiliation_strings":["Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA","Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Bradley Dept. of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":null,"first_page":"1344","last_page":"1347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.9617999792098999,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.5881228446960449},{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.5772994160652161},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.49475783109664917},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.46430259943008423},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.44809654355049133},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4044601321220398},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3790907859802246},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"Physical therapy","score":0.3394419550895691},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.26710376143455505},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.19533267617225647}],"concepts":[{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.5881228446960449},{"id":"https://openalex.org/C2778943923","wikidata":"https://www.wikidata.org/wiki/Q1648484","display_name":"Duchenne muscular dystrophy","level":2,"score":0.5772994160652161},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.49475783109664917},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.46430259943008423},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.44809654355049133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4044601321220398},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3790907859802246},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3394419550895691},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26710376143455505},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19533267617225647},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/globalsip.2014.7032343","is_oa":false,"landing_page_url":"https://doi.org/10.1109/globalsip.2014.7032343","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE Global Conference on Signal and Information Processing (GlobalSIP)","raw_type":"proceedings-article"},{"id":"pmh:oai:www.research.unipd.it:11577/3411587","is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/3411587","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7400000095367432}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306106","display_name":"U.S. Department of Education","ror":"https://ror.org/021adze67"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1967629400","https://openalex.org/W1980429541","https://openalex.org/W2001604199","https://openalex.org/W2015511652","https://openalex.org/W2041052974","https://openalex.org/W2111944842","https://openalex.org/W2129442835","https://openalex.org/W2787894218"],"related_works":["https://openalex.org/W2016075297","https://openalex.org/W2580749893","https://openalex.org/W4304607425","https://openalex.org/W4390262343","https://openalex.org/W2609128540","https://openalex.org/W4380149017","https://openalex.org/W4390124745","https://openalex.org/W3027614635","https://openalex.org/W2075131001","https://openalex.org/W2111292213"],"abstract_inverted_index":{"Although":[0],"Duchenne":[1],"muscular":[2,96],"dystrophy":[3],"(DMD),":[4],"the":[5,42,103,106,120,133,138,164,190,194,220,228,245],"most":[6],"common":[7],"single-gene":[8],"lethal":[9],"disorder,":[10],"is":[11,27,34,46,60,143,223],"caused":[12],"by":[13,215],"a":[14,35,231],"homogeneous":[15],"biochemical":[16],"defect":[17],"in":[18,24,174],"all":[19,185],"patients,":[20],"substantial":[21],"patient-patient":[22],"variety":[23],"disease":[25,53],"progression":[26,40],"observed.":[28],"The":[29,217],"loss":[30],"of":[31,38,52,95,122,132,200,206,219,234],"ambulation":[32],"(LoA)":[33],"functional":[36],"milestone":[37],"DMD":[39,175,235],"and":[41,98,101,112,136,156,204,237],"age":[43,57,88,171,238],"at":[44,58,70,89,172,193,239],"LoA":[45,59,90,173,240],"often":[47],"used":[48],"as":[49,56,65,152,212],"an":[50],"indication":[51],"severity.":[54],"But":[55],"not":[61,184],"always":[62],"available,":[63],"such":[64,151],"when":[66,244],"patients":[67],"remain":[68],"ambulant":[69],"study":[71],"end,":[72],"its":[73],"use":[74],"has":[75,241],"been":[76],"limited.":[77],"In":[78],"this":[79],"paper,":[80],"we":[81,116,162,181],"report":[82],"machine":[83],"learning":[84],"approaches":[85,150],"to":[86,166,189],"predict":[87],"based":[91,140],"on":[92,141],"clinical":[93,124,177,186],"measures":[94,187],"strength":[97],"motor":[99],"function,":[100],"validate":[102],"algorithms":[104],"using":[105,130,176],"CINRG":[107],"dataset.":[108],"With":[109],"extensive":[110],"experiments":[111],"rigorous":[113],"statistical":[114],"analysis,":[115],"found":[117],"that":[118,183,227],"(1)":[119],"utilization":[121],"multiple":[123],"features":[125],"yields":[126],"better":[127,242],"prediction":[128,139,221],"than":[129,146],"any":[131],"single":[134],"measures,":[135],"(2)":[137],"Lasso":[142],"more":[144],"accurate":[145],"other":[147],"multivariate":[148],"analytical":[149],"ordinary":[153],"least":[154],"squares":[155],"ridge":[157],"regression.":[158],"To":[159],"our":[160],"knowledge,":[161],"are":[163,210,248],"first":[165],"provide":[167],"point":[168],"predictions":[169],"for":[170],"phenotypic":[178],"measures.":[179],"Importantly,":[180],"find":[182],"contribute":[188],"prediction.":[191],"Age":[192],"last":[195],"visit":[196],"(before":[197],"LoA),":[198],"velocity":[199,205],"walking":[201],"10":[202],"meters,":[203],"climbing":[207],"4":[208],"steps":[209],"selected":[211],"important":[213],"predictors":[214],"Lasso.":[216],"usefulness":[218],"model":[222],"illustrated":[224],"with":[225],"evidence":[226],"association":[229],"between":[230],"well-known":[232],"modifier":[233],"severity":[236],"power":[243],"predicted":[246],"values":[247],"utilized.":[249]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
