{"id":"https://openalex.org/W2545957730","doi":"https://doi.org/10.1109/globalsip.2013.6736819","title":"Identifying deregulated TF/miRNA negative and double-negative feedback loops in prostate cancer","display_name":"Identifying deregulated TF/miRNA negative and double-negative feedback loops in prostate cancer","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2545957730","doi":"https://doi.org/10.1109/globalsip.2013.6736819","mag":"2545957730"},"language":"en","primary_location":{"id":"doi:10.1109/globalsip.2013.6736819","is_oa":false,"landing_page_url":"https://doi.org/10.1109/globalsip.2013.6736819","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE Global Conference on Signal and Information Processing","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002020800","display_name":"Ali Afshar","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Sobhi Afshar","raw_affiliation_strings":["Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049808759","display_name":"Joseph Xu","orcid":"https://orcid.org/0000-0001-8831-4298"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Xu","raw_affiliation_strings":["Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040506666","display_name":"John Goutsias","orcid":"https://orcid.org/0000-0002-0192-3857"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Goutsias","raw_affiliation_strings":["Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.29353234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"102","issue":null,"first_page":"85","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.854479193687439},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6365199089050293},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.6187703013420105},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5694828033447266},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5595610737800598},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5521187782287598},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5168209671974182},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.5070221424102783},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.38288748264312744},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3765624761581421},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20913982391357422}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.854479193687439},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6365199089050293},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6187703013420105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5694828033447266},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5595610737800598},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5521187782287598},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5168209671974182},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5070221424102783},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38288748264312744},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3765624761581421},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20913982391357422},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/globalsip.2013.6736819","is_oa":false,"landing_page_url":"https://doi.org/10.1109/globalsip.2013.6736819","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE Global Conference on Signal and Information Processing","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7599999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1976324983","https://openalex.org/W1976739900","https://openalex.org/W1998566859","https://openalex.org/W2016360721","https://openalex.org/W2017270642","https://openalex.org/W2018819150","https://openalex.org/W2027297938","https://openalex.org/W2067419055","https://openalex.org/W2096192437","https://openalex.org/W2115094397","https://openalex.org/W2130410032","https://openalex.org/W2167591147","https://openalex.org/W2170989872"],"related_works":["https://openalex.org/W2737319532","https://openalex.org/W3151405604","https://openalex.org/W2128583238","https://openalex.org/W2134405083","https://openalex.org/W2049907435","https://openalex.org/W2034500416","https://openalex.org/W2057742104","https://openalex.org/W2034377088","https://openalex.org/W4283692078","https://openalex.org/W2025542119"],"abstract_inverted_index":{"Transcription":[0],"factors":[1],"(TFs)":[2],"and":[3,28,53,61,67,85,96,132],"MicroRNAs":[4],"(miRNAs)":[5],"are":[6],"two":[7,109],"important":[8,71],"regulators":[9],"of":[10,18,46,83,92,111,137],"gene":[11],"expression":[12],"in":[13,64,116,140],"cells.":[14],"Although":[15],"a":[16,43,87,134],"wealth":[17],"information":[19],"is":[20,35,69],"available":[21],"on":[22],"how":[23],"TFs":[24,52],"bind":[25],"their":[26,31,62],"targets":[27],"carry":[29],"out":[30],"regulatory":[32],"roles,":[33],"this":[34,100],"not":[36],"true":[37],"for":[38,89,107],"miRNAs.":[39,57],"Recent":[40],"observations":[41],"suggest":[42],"high":[44],"level":[45],"coordination":[47],"between":[48],"transcriptional":[49],"regulation":[50,55],"by":[51,56],"post-transcriptional":[54],"Understanding":[58],"TF/miRNA":[59,112,130],"interactions":[60,131],"roles":[63],"tumor":[65],"initiation":[66],"progression":[68],"an":[70,104],"problem":[72],"that":[73],"may":[74],"lead":[75],"to":[76,124,129],"systemic":[77],"insights":[78],"into":[79],"the":[80,90],"molecular":[81],"biology":[82],"cancer":[84],"form":[86],"basis":[88],"development":[91],"new":[93],"diagnostic":[94],"tools":[95],"therapeutic":[97],"approaches.":[98],"In":[99],"paper,":[101],"we":[102],"propose":[103],"integrated":[105],"approach":[106,120],"identifying":[108],"types":[110],"feedback":[113],"loops":[114],"deregulated":[115],"prostate":[117],"cancer.":[118,141],"Our":[119],"can":[121],"be":[122],"used":[123],"assign":[125],"context-dependent":[126],"biological":[127],"functions":[128],"provide":[133],"better":[135],"understanding":[136],"miRNA":[138],"deregulation":[139]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
