{"id":"https://openalex.org/W1967777069","doi":"https://doi.org/10.1109/gensips.2013.6735926","title":"Exploiting the cancer and diabetes metabolic connection for therapeutic purposes","display_name":"Exploiting the cancer and diabetes metabolic connection for therapeutic purposes","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W1967777069","doi":"https://doi.org/10.1109/gensips.2013.6735926","mag":"1967777069"},"language":"en","primary_location":{"id":"doi:10.1109/gensips.2013.6735926","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2013.6735926","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Workshop on Genomic Signal Processing and Statistics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062394853","display_name":"Osama A. Arshad","orcid":null},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Osama A. Arshad","raw_affiliation_strings":["Venkatasubramami, Texas A&M University College Station, TX, USA","Dept. of Electr. & Comput. Eng, Texas A&M Univ., College Station, TX, USA"],"affiliations":[{"raw_affiliation_string":"Venkatasubramami, Texas A&M University College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng, Texas A&M Univ., College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064770044","display_name":"Priyadharshini S. Venkatasubramami","orcid":null},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyadharshini S. Venkatasubramami","raw_affiliation_strings":["Texas A&M University College Station, College Station, TX, US","Dept. of Electr. & Comput. Eng, Texas A&M Univ., College Station, TX, USA"],"affiliations":[{"raw_affiliation_string":"Texas A&M University College Station, College Station, TX, US","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng, Texas A&M Univ., College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045462352","display_name":"Aniruddha Datta","orcid":"https://orcid.org/0000-0003-1213-3807"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aniruddha Datta","raw_affiliation_strings":["Texas A&M University College Station, College Station, TX, US","Dept. of Electr. & Comput. Eng, Texas A&M Univ., College Station, TX, USA"],"affiliations":[{"raw_affiliation_string":"Texas A&M University College Station, College Station, TX, US","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng, Texas A&M Univ., College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032872866","display_name":"Jijayanagaram Venkatraj","orcid":null},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jijayanagaram Venkatraj","raw_affiliation_strings":["Texas A&M University College Station, College Station, TX, US","Coll. of Veterinary Med. & Biomed. Sci., Texas A&M Univ., College Station, TX, USA"],"affiliations":[{"raw_affiliation_string":"Texas A&M University College Station, College Station, TX, US","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Coll. of Veterinary Med. & Biomed. Sci., Texas A&M Univ., College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062394853"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":0.2924,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.59809195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"44","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"Metformin","score":0.8865984082221985},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.7494698762893677},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.7138025164604187},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5933158993721008},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5751723051071167},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.5642781257629395},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.4551848769187927},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.4122995138168335},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.38955584168434143},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.38938871026039124},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.36794382333755493},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3633119463920593},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3514291048049927},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24750685691833496},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.22534871101379395}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.8865984082221985},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7494698762893677},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7138025164604187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5933158993721008},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5751723051071167},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5642781257629395},{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.4551848769187927},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4122995138168335},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38955584168434143},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38938871026039124},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36794382333755493},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3633119463920593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3514291048049927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24750685691833496},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22534871101379395}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/gensips.2013.6735926","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2013.6735926","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Workshop on Genomic Signal Processing and Statistics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2098846525","https://openalex.org/W4245662196"],"related_works":["https://openalex.org/W1982087887","https://openalex.org/W2055409115","https://openalex.org/W2313378189","https://openalex.org/W3015481613","https://openalex.org/W2537551256","https://openalex.org/W3198945369","https://openalex.org/W3080964358","https://openalex.org/W1982281722","https://openalex.org/W2980982934","https://openalex.org/W2004222701"],"abstract_inverted_index":{"The":[0],"uncontrolled":[1],"cell":[2,19],"proliferation":[3],"that":[4,73],"is":[5,10,47,62],"characteristically":[6],"associated":[7],"with":[8,77,93,129],"cancer":[9,25,87,109,119],"usually":[11],"accompanied":[12],"by":[13,64],"alterations":[14],"in":[15,36,108,127],"the":[16,22,37,44,54,78,104,114],"genome":[17],"and":[18,136],"metabolism.":[20],"Indeed,":[21],"phenomenon":[23],"of":[24,39,53,56,86,103,116],"cells":[26],"metabolizing":[27],"glucose":[28],"using":[29,144],"a":[30,99],"less":[31,137],"efficient":[32],"anaerobic":[33],"process":[34],"even":[35],"presence":[38],"normal":[40],"oxygen":[41],"levels,":[42],"termed":[43],"Warburg":[45],"effect,":[46],"currently":[48],"considered":[49],"to":[50,90,110,143],"be":[51],"one":[52],"hallmarks":[55],"cancer.":[57],"Diabetes,":[58],"much":[59],"like":[60],"cancer,":[61],"defined":[63],"significant":[65],"metabolic":[66],"changes.":[67],"Recent":[68],"epidemiological":[69],"studies":[70],"have":[71,82],"shown":[72],"diabetes":[74],"patients":[75,91],"treated":[76,92],"anti-diabetic":[79,95],"drug":[80],"Metformin,":[81],"significantly":[83],"lowered":[84],"risk":[85],"as":[88,141],"compared":[89,142],"other":[94],"drugs.":[96],"We":[97],"utilize":[98],"Boolean":[100],"logic":[101],"model":[102],"pathways":[105],"commonly":[106],"mutated":[107],"not":[111],"only":[112],"investigate":[113],"efficacy":[115],"Metformin":[117,126],"for":[118],"therapeutic":[120,131],"purposes":[121],"but":[122],"also":[123],"demonstrate":[124],"how":[125],"concert":[128],"standard":[130],"drugs":[132],"could":[133],"provide":[134],"better":[135],"toxic":[138],"clinical":[139],"outcomes":[140],"chemotherapy":[145],"alone.":[146]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}