{"id":"https://openalex.org/W2020748862","doi":"https://doi.org/10.1109/gensips.2013.6735923","title":"Compromised intervention policies for phenotype alteration","display_name":"Compromised intervention policies for phenotype alteration","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2020748862","doi":"https://doi.org/10.1109/gensips.2013.6735923","mag":"2020748862"},"language":"en","primary_location":{"id":"doi:10.1109/gensips.2013.6735923","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2013.6735923","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Workshop on Genomic Signal Processing and Statistics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111733816","display_name":"Mohammadmahdi R. Yousefi","orcid":null},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mohammadmahdi R. Yousefi","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, USA","Dept. of Electr. & Comput. Eng., Ohio state Univ., Columbus, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng., Ohio state Univ., Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111733816"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06642868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"32","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9703999757766724,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.6570959091186523},{"id":"https://openalex.org/keywords/intervention","display_name":"Intervention (counseling)","score":0.5709033608436584},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44424453377723694},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19206178188323975},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.18582811951637268},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13368719816207886},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12069350481033325}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6570959091186523},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5709033608436584},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44424453377723694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19206178188323975},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.18582811951637268},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13368719816207886},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12069350481033325},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/gensips.2013.6735923","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2013.6735923","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Workshop on Genomic Signal Processing and Statistics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1518931405","https://openalex.org/W1545070306","https://openalex.org/W1967233669","https://openalex.org/W2001139238","https://openalex.org/W2050533213","https://openalex.org/W2086150890","https://openalex.org/W2106034845","https://openalex.org/W2113799780","https://openalex.org/W2132935366","https://openalex.org/W2160533336","https://openalex.org/W2160904474","https://openalex.org/W2163294044","https://openalex.org/W4388252848"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2382290278"],"abstract_inverted_index":{"We":[0,24,74],"take":[1],"a":[2,76,87],"Markovian":[3],"approach":[4],"to":[5,37,61,119],"modeling":[6],"gene":[7],"regulatory":[8],"networks":[9],"and":[10,91],"assume":[11],"that":[12,28],"phenotypes":[13],"are":[14,57],"characterized":[15],"by":[16],"the":[17,31,49,62,101,116,124],"steady-state":[18,50],"probability":[19,32],"distribution":[20],"of":[21,52,64,79,103,115],"such":[22],"networks.":[23],"desire":[25],"intervention":[26,94],"policies":[27,108],"maximally":[29],"shift":[30],"mass":[33,51,118],"from":[34],"undesirable":[35,125],"states":[36],"desirable":[38],"ones.":[39],"In":[40],"doing":[41],"so,":[42],"we":[43,99,111],"might":[44],"also":[45],"be":[46,68],"concerned":[47],"about":[48],"some":[53,71,113],"\u201cambiguous\u201d":[54],"states,":[55],"which":[56,110],"not":[58],"directly":[59],"related":[60],"pathology":[63],"interest":[65],"but":[66],"could":[67],"associated":[69],"with":[70],"anticipated":[72],"risks.":[73],"propose":[75],"direct":[77],"formulation":[78],"this":[80,97],"constrained":[81],"optimization":[82],"problem,":[83],"rather":[84],"than":[85],"assuming":[86],"subjective":[88],"cost":[89],"function,":[90],"provide":[92],"optimal":[93],"policies.":[95],"Within":[96],"framework,":[98],"investigate":[100],"performance":[102],"\u201ccompromised\u201d":[104],"policies,":[105],"these":[106],"being":[107],"for":[109],"accept":[112],"increase":[114],"ambiguous":[117],"achieve":[120],"more":[121],"decrease":[122],"in":[123],"mass.":[126]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}