{"id":"https://openalex.org/W2033465469","doi":"https://doi.org/10.1109/gensips.2013.6735920","title":"Characterization of conditions for competing endogenous RNA regulation in GBM","display_name":"Characterization of conditions for competing endogenous RNA regulation in GBM","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2033465469","doi":"https://doi.org/10.1109/gensips.2013.6735920","mag":"2033465469"},"language":"en","primary_location":{"id":"doi:10.1109/gensips.2013.6735920","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2013.6735920","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Workshop on Genomic Signal Processing and Statistics","raw_type":"proceedings-article"},"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028190064","display_name":"Yu\u2010Chiao Chiu","orcid":"https://orcid.org/0000-0003-1647-8634"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chiao Chiu","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics and Bioinformatics","Grad. Inst. of Biomed., Electron. & Bioinf., Nat. Taiwan Univ., Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinformatics","institution_ids":[]},{"raw_affiliation_string":"Grad. Inst. of Biomed., Electron. & Bioinf., Nat. Taiwan Univ., Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062893898","display_name":"Eric Y. Chuang","orcid":"https://orcid.org/0000-0003-2530-0096"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Eric Y. Chuang","raw_affiliation_strings":["Bioinformatics and Biostatistics Core, National Taiwan University, Taipei, Taiwan","Grad. Inst. of Biomed., Electron. & Bioinf., Nat. Taiwan Univ., Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Biostatistics Core, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Grad. Inst. of Biomed., Electron. & Bioinf., Nat. Taiwan Univ., Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102940992","display_name":"Tzu\u2010Hung Hsiao","orcid":"https://orcid.org/0000-0003-0365-9970"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4210121077","display_name":"Cancer Research Institute of the Slovak Academy of Sciences","ror":"https://ror.org/02v8wkr26","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210121077"]}],"countries":["SK","US"],"is_corresponding":false,"raw_author_name":"Tzu-Hung Hsiao","raw_affiliation_strings":["Greehey Children's Cancer Research Institute","Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio , San Antonio, TX , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greehey Children's Cancer Research Institute","institution_ids":["https://openalex.org/I4210121077"]},{"raw_affiliation_string":"Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio , San Antonio, TX , USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100689062","display_name":"Yidong Chen","orcid":"https://orcid.org/0000-0002-2627-5016"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4210121077","display_name":"Cancer Research Institute of the Slovak Academy of Sciences","ror":"https://ror.org/02v8wkr26","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210121077"]}],"countries":["SK","US"],"is_corresponding":false,"raw_author_name":"Yidong Chen","raw_affiliation_strings":["Greehey Children's Cancer Research Institute","Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio , San Antonio, TX , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greehey Children's Cancer Research Institute","institution_ids":["https://openalex.org/I4210121077"]},{"raw_affiliation_string":"Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio , San Antonio, TX , USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9786999821662903,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/competing-endogenous-rna","display_name":"Competing endogenous RNA","score":0.9825703501701355},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7892509698867798},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6808785796165466},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6179227232933044},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6051479578018188},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4717482030391693},{"id":"https://openalex.org/keywords/untranslated-region","display_name":"Untranslated region","score":0.4230876564979553},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4200581908226013},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.36738109588623047},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30396541953086853},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"Long non-coding RNA","score":0.1546558141708374}],"concepts":[{"id":"https://openalex.org/C60365752","wikidata":"https://www.wikidata.org/wiki/Q5156306","display_name":"Competing endogenous RNA","level":5,"score":0.9825703501701355},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7892509698867798},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6808785796165466},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6179227232933044},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6051479578018188},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4717482030391693},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.4230876564979553},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4200581908226013},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.36738109588623047},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30396541953086853},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.1546558141708374}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/gensips.2013.6735920","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2013.6735920","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Workshop on Genomic Signal Processing and Statistics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1998618295","https://openalex.org/W3135639358","https://openalex.org/W2605415066","https://openalex.org/W2586183753","https://openalex.org/W3134273865","https://openalex.org/W2128583238","https://openalex.org/W2134405083","https://openalex.org/W2049907435","https://openalex.org/W2034500416","https://openalex.org/W2034377088"],"abstract_inverted_index":{"Summary":[0],"form":[1],"only":[2],"given.":[3],"MicroRNAs":[4],"(miRNAs)":[5],"are":[6,18],"short":[7],"non-coding":[8],"RNAs":[9,61],"with":[10,210,215],"the":[11,58,106,113,127,141,177,184,223,268,274,287,293,315,331,355,365],"average":[12],"length":[13],"of":[14,26,37,69,77,126,146,158,161,167,172,196,205,231,258,267,278,310,317,327,334,350,364],"22":[15],"nucleotides.":[16],"They":[17],"known":[19],"to":[20,31,90,189,344,392],"induce":[21],"mRNA":[22,39],"degradation":[23],"or":[24,82],"suppression":[25],"translation":[27],"by":[28,201,241],"complementarily":[29],"binding":[30,86,163,319],"3'":[32],"untranslated":[33],"regions":[34],"(3'":[35],"UTRs)":[36],"target":[38],"transcripts.":[40],"Recently,":[41],"an":[42],"alternative":[43],"mechanism":[44,396],"through":[45],"which":[46],"miRNAs":[47,72,85,108,234],"participate":[48],"in":[49,100,117,132,135,153,183,199,348,376,387],"gene":[50,219,259],"regulation":[51,155,198,360],"was":[52,289],"postulated":[53],"and":[54,116,134,143,169,218,240,272,285,296,324,337,342,368,373,390],"experimentally":[55],"validated,":[56],"namely":[57],"competing":[59,64],"endogenous":[60],"(ceRNAs).":[62],"By":[63],"for":[65,180,265,280,291,299],"a":[66,236],"limited":[67],"pool":[68],"common":[70,232],"targeting":[71,107,233],"(miRNA":[73],"programs;":[74],"miRP),":[75],"pairs":[76],"genes":[78,227],"(ceRNAs)":[79],"sharing,":[80],"fully":[81],"partially,":[83],"identical":[84],"sites":[87,320],"can":[88],"\u201ctalk\u201d":[89],"each":[91,266],"other:":[92],"when":[93],"one":[94],"ceRNA":[95,147,154,181,197,238,249,270,301,322,328,340,359,385,398],"is":[96],"up-regulated":[97],"(or":[98,104,111,121],"down-regulated)":[99],"cells,":[101],"it":[102],"attracts":[103],"releases)":[105],"away":[109],"from":[110],"toward)":[112],"other":[114,128],"ceRNA,":[115],"turn":[118],"have":[119],"protective":[120],"harmful)":[122],"effects":[123],"on":[124,131,222,362],"expression":[125,165,170,260,332],"ceRNA.":[129],"Based":[130,221],"silico":[133],"vitro":[136],"analysis,":[137],"recent":[138],"reports":[139],"suggested":[140],"dynamic":[142,374],"condition-specific":[144],"properties":[145],"regulation.":[148,399],"The":[149],"essential":[150,192,294,366],"factors":[151,193,295,367],"involved":[152],"include":[156],"size":[157,277,309],"miRP,":[159,168,279],"number":[160,230],"miRP":[162,318],"sites,":[164],"level":[166,171],"ceRNAs.":[173],"For":[174],"better":[175],"characterizing":[176],"optimal":[178,297],"conditions":[179,298],"regulation,":[182],"present":[185],"study":[186],"we":[187,245],"aim":[188],"confer":[190],"how":[191],"determine":[194],"strength":[195],"vivo,":[200],"analyzing":[202],"TCGA":[203],"datasets":[204],"glioblastoma":[206,388],"multiforme":[207,389],"(GBM)":[208],"patients":[209],"491":[211],"tumor":[212],"samples":[213],"profiled":[214],"paired":[216],"miRNA":[217],"expression.":[220],"definition":[224],"that":[225,307,358],"two":[226],"sharing":[228],"any":[229],"as":[235,312,314],"putative":[237,248,269],"pair,":[239],"utilizing":[242],"TargetScan":[243],"algorithm,":[244],"identified":[246],"47,451,423":[247],"pairs,":[250,271],"involving":[251],"10,872":[252],"ceRNAs":[253,338],"(genes).":[254],"Pairwise":[255],"correlation":[256,351],"coefficients":[257],"profiles":[261],"were":[262],"then":[263,273,286],"computed":[264],"CDF.":[275],"Varying":[276],"example,":[281],"generated":[282],"multiple":[283],"CDFs,":[284],"goodness-of-fit":[288],"performed":[290],"pinpointing":[292],"intensified":[300],"activity.":[302],"Our":[303,378],"analysis":[304],"results":[305,356],"demonstrated":[306],"increased":[308],"miRPs":[311,336],"well":[313],"abundance":[316],"stabilize":[321],"activity":[323,341],"strengthen":[325],"coexpression":[326],"pairs.":[329],"Furthermore,":[330],"levels":[333],"both":[335],"affect":[339],"lead":[343],"statistically":[345],"significant":[346],"differences":[347],"distributions":[349],"coefficients.":[352],"Taken":[353],"together,":[354],"indicated":[357],"depends":[361],"states":[363],"thus":[369],"may":[370],"involve":[371],"complex":[372,384,395],"processes":[375],"vivo.":[377],"findings":[379],"bring":[380],"biological":[381],"insights":[382],"into":[383],"crosstalk":[386],"contribute":[391],"further":[393],"unveiling":[394],"governing":[397]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}