{"id":"https://openalex.org/W2034158797","doi":"https://doi.org/10.1109/gensips.2012.6507738","title":"Comprehensive analyses of tumor suppressor genes in protein-protein interaction networks: A topological perspective","display_name":"Comprehensive analyses of tumor suppressor genes in protein-protein interaction networks: A topological perspective","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2034158797","doi":"https://doi.org/10.1109/gensips.2012.6507738","mag":"2034158797"},"language":"en","primary_location":{"id":"doi:10.1109/gensips.2012.6507738","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2012.6507738","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings 2012 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058802996","display_name":"Min Zhao","orcid":"https://orcid.org/0000-0001-5498-3434"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Min Zhao","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University School of Medicine Nashville, TN 37232, USA","Department of Biomedical Informatics, Vanderbilt University School of Medicine,Nashville, TN 37232, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine,Nashville, TN 37232, USA#TAB#","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052779340","display_name":"Jingchun Sun","orcid":"https://orcid.org/0000-0002-3284-7973"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingchun Sun","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University School of Medicine Nashville, TN 37232, USA","Department of Biomedical Informatics, Vanderbilt University School of Medicine,Nashville, TN 37232, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine,Nashville, TN 37232, USA#TAB#","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006688612","display_name":"Zhongming Zhao","orcid":"https://orcid.org/0000-0002-3477-0914"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongming Zhao","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University School of Medicine Nashville, TN 37232, USA","Department of Biomedical Informatics, Vanderbilt University School of Medicine,Nashville, TN 37232, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine,Nashville, TN 37232, USA#TAB#","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058802996"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":0.1345,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.52033019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"101","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9710000157356262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9690999984741211,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6378892660140991},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6069952249526978},{"id":"https://openalex.org/keywords/suppressor","display_name":"Suppressor","score":0.5973998308181763},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.509318470954895},{"id":"https://openalex.org/keywords/closeness","display_name":"Closeness","score":0.4814797639846802},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4512570798397064},{"id":"https://openalex.org/keywords/homology","display_name":"Homology (biology)","score":0.4432862102985382},{"id":"https://openalex.org/keywords/betweenness-centrality","display_name":"Betweenness centrality","score":0.4116429388523102},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.06574991345405579}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6378892660140991},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6069952249526978},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5973998308181763},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.509318470954895},{"id":"https://openalex.org/C2779545769","wikidata":"https://www.wikidata.org/wiki/Q5135364","display_name":"Closeness","level":2,"score":0.4814797639846802},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4512570798397064},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.4432862102985382},{"id":"https://openalex.org/C117045392","wikidata":"https://www.wikidata.org/wiki/Q4899215","display_name":"Betweenness centrality","level":3,"score":0.4116429388523102},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.06574991345405579},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/gensips.2012.6507738","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2012.6507738","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings 2012 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"},{"id":"pmh:usc:13926","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/GENSIPS.2012.6507738","pdf_url":null,"source":{"id":"https://openalex.org/S4306401632","display_name":"USC Research Bank (University of the Sunshine Coast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I174025329","host_organization_name":"University of the Sunshine Coast","host_organization_lineage":["https://openalex.org/I174025329"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Paper"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1567424149","https://openalex.org/W1968744462","https://openalex.org/W2010768245","https://openalex.org/W2037324746","https://openalex.org/W2048296798","https://openalex.org/W2096525273","https://openalex.org/W2100894466","https://openalex.org/W2102140136","https://openalex.org/W2112651905","https://openalex.org/W2115899293","https://openalex.org/W2134344399","https://openalex.org/W2155699197","https://openalex.org/W2156443053","https://openalex.org/W2172049947","https://openalex.org/W4231170962"],"related_works":["https://openalex.org/W1516497519","https://openalex.org/W2356738361","https://openalex.org/W2012724202","https://openalex.org/W3006871705","https://openalex.org/W4205555748","https://openalex.org/W2166456073","https://openalex.org/W2886295835","https://openalex.org/W2118175818","https://openalex.org/W3144459458","https://openalex.org/W4297813505"],"abstract_inverted_index":{"Tumor":[0],"suppressor":[1,50],"genes":[2,8,133],"(TSGs)":[3],"are":[4,154],"a":[5],"class":[6],"of":[7,21,100,118,172,191],"that":[9,122,152],"play":[10],"key":[11],"roles":[12,34],"in":[13,23,35,134,174,182],"cancer":[14,36,148,163],"induction":[15],"and":[16,76,84,107,138,193],"development.":[17,37,164],"A":[18],"comprehensive":[19],"investigation":[20],"TSGs":[22,62,83,89,101,123,153,173,192],"protein-protein":[24],"interaction":[25,158,195],"(PPI)":[26],"networks":[27],"may":[28],"expand":[29],"our":[30],"understanding":[31],"on":[32,147],"their":[33,85,91,104,194],"In":[38,177],"this":[39,183],"study,":[40],"we":[41,59,87,102],"first":[42,169],"collected":[43],"reliable":[44],"human":[45,61,72,82],"TSG":[46],"lists":[47],"from":[48],"tumor":[49],"gene":[51],"database.":[52],"To":[53,95],"provide":[54],"an":[55],"unbiased":[56],"network":[57,98],"view,":[58],"mapped":[60],"to":[63,71,90,125,156],"four":[64],"model":[65],"organisms":[66],"with":[67,114,159],"different":[68],"evolutionary":[69],"distances":[70],"(mouse,":[73],"fly,":[74,137],"worm,":[75,139],"yeast)":[77],"using":[78],"homology":[79],"relationship.":[80],"Using":[81],"homologs,":[86],"overlapped":[88],"corresponding":[92],"PPI":[93,175],"networks.":[94,176],"explore":[96],"the":[97,168,179,189],"properties":[99],"examined":[103],"degree,":[105],"betweenness,":[106],"closeness":[108],"centralities":[109],"by":[110],"uniquely":[111],"comparing":[112],"them":[113],"three":[115],"other":[116,130,160],"sets":[117],"genes.":[119,149],"We":[120],"found":[121],"tend":[124],"interact":[126],"more":[127],"strongly":[128],"than":[129],"non-cancer":[131],"disease":[132],"human,":[135],"mouse,":[136],"which":[140],"confirmed":[141],"previous":[142],"global":[143],"topological":[144],"property":[145],"studies":[146],"This":[150,165],"demonstrates":[151],"important":[155],"initiate":[157],"molecular":[161],"during":[162],"study":[166,184,190],"represents":[167],"statistical":[170],"evaluation":[171],"addition,":[178],"data":[180],"presented":[181],"will":[185],"be":[186],"valuable":[187],"for":[188],"partners.":[196]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}