{"id":"https://openalex.org/W2080663431","doi":"https://doi.org/10.1109/gensips.2012.6507726","title":"Combination therapy design for targeted therapeutics from a drug-protein interaction perspective","display_name":"Combination therapy design for targeted therapeutics from a drug-protein interaction perspective","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2080663431","doi":"https://doi.org/10.1109/gensips.2012.6507726","mag":"2080663431"},"language":"en","primary_location":{"id":"doi:10.1109/gensips.2012.6507726","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2012.6507726","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings 2012 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016562514","display_name":"Saad Haider","orcid":null},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Saad Haider","raw_affiliation_strings":["Texas Tech University Lubbock, TX, 79409, USA","Texas Tech University, Lubbock, TX, 79409, USA"],"affiliations":[{"raw_affiliation_string":"Texas Tech University Lubbock, TX, 79409, USA","institution_ids":["https://openalex.org/I12315562"]},{"raw_affiliation_string":"Texas Tech University, Lubbock, TX, 79409, USA","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089263262","display_name":"Noah Berlow","orcid":"https://orcid.org/0000-0001-8666-3152"},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah Berlow","raw_affiliation_strings":["Texas Tech University Lubbock, TX, 79409, USA","Texas Tech University, Lubbock, TX, 79409, USA"],"affiliations":[{"raw_affiliation_string":"Texas Tech University Lubbock, TX, 79409, USA","institution_ids":["https://openalex.org/I12315562"]},{"raw_affiliation_string":"Texas Tech University, Lubbock, TX, 79409, USA","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025450455","display_name":"Ranadip Pal","orcid":"https://orcid.org/0000-0002-9311-5901"},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranadip Pal","raw_affiliation_strings":["Texas Tech University Lubbock, TX, 79409, USA","Texas Tech University, Lubbock, TX, 79409, USA"],"affiliations":[{"raw_affiliation_string":"Texas Tech University Lubbock, TX, 79409, USA","institution_ids":["https://openalex.org/I12315562"]},{"raw_affiliation_string":"Texas Tech University, Lubbock, TX, 79409, USA","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082683623","display_name":"Lara E. Davis","orcid":"https://orcid.org/0000-0002-6480-1611"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lara Davis","raw_affiliation_strings":["Oregon Health & Science University Portland, Oregon, 97239, USA","Oregon Health and Science University, Portland, Oregon 97239, USA"],"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University Portland, Oregon, 97239, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health and Science University, Portland, Oregon 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009653245","display_name":"Charles Keller","orcid":"https://orcid.org/0000-0003-2505-7487"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Keller","raw_affiliation_strings":["Oregon Health & Science University Portland, Oregon, 97239, USA","Oregon Health and Science University, Portland, Oregon 97239, USA"],"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University Portland, Oregon, 97239, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health and Science University, Portland, Oregon 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5016562514"],"corresponding_institution_ids":["https://openalex.org/I12315562"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.13966763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"439","issue":null,"first_page":"58","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5950853824615479},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"Combination therapy","score":0.5787292718887329},{"id":"https://openalex.org/keywords/hill-climbing","display_name":"Hill climbing","score":0.4802180230617523},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"Cancer therapy","score":0.4626534581184387},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.454714298248291},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.450916588306427},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.4359620213508606},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"Targeted therapy","score":0.43470993638038635},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4141552150249481},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39648115634918213},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3215788006782532},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.31524911522865295},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.28438013792037964},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1713324785232544},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11600357294082642},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.08312481641769409}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5950853824615479},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.5787292718887329},{"id":"https://openalex.org/C135450995","wikidata":"https://www.wikidata.org/wiki/Q820272","display_name":"Hill climbing","level":2,"score":0.4802180230617523},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.4626534581184387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.454714298248291},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.450916588306427},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.4359620213508606},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.43470993638038635},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4141552150249481},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39648115634918213},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3215788006782532},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31524911522865295},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28438013792037964},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1713324785232544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11600357294082642},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08312481641769409},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/gensips.2012.6507726","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2012.6507726","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings 2012 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1972841394","https://openalex.org/W2011187792","https://openalex.org/W2039298370","https://openalex.org/W2100772783","https://openalex.org/W2105572154","https://openalex.org/W2156761481","https://openalex.org/W4237492341","https://openalex.org/W4255537561"],"related_works":["https://openalex.org/W3082935376","https://openalex.org/W4399651953","https://openalex.org/W4386960999","https://openalex.org/W2899657781","https://openalex.org/W4322484660","https://openalex.org/W3193951088","https://openalex.org/W4388011470","https://openalex.org/W4230423494","https://openalex.org/W4298001029","https://openalex.org/W4393252403"],"abstract_inverted_index":{"In":[0,54],"the":[1,28,39,59,77],"last":[2],"decade,":[3],"a":[4,22,70,110,115],"number":[5],"of":[6,41,51,61,72,123],"drugs":[7,48],"targeting":[8,97],"specific":[9],"proteins":[10],"have":[11],"been":[12],"developed":[13],"that":[14,34],"are":[15],"becoming":[16],"common":[17],"in":[18,31],"cancer":[19,37],"research":[20],"as":[21,44],"basis":[23],"for":[24,49,101],"personalized":[25],"therapy.":[26],"How-ever,":[27],"numerous":[29],"aberrations":[30],"molecular":[32],"pathways":[33,100],"can":[35],"produce":[36],"necessitate":[38],"use":[40],"drug":[42,84,95],"combinations":[43,85,96],"compared":[45],"to":[46],"single":[47],"treatment":[50],"individual":[52],"cancers.":[53],"this":[55],"article,":[56],"we":[57],"consider":[58,76],"design":[60],"combination":[62],"therapy":[63],"based":[64],"on":[65,129],"tumor":[66],"sensitivity":[67,88],"measurements":[68],"over":[69],"panel":[71],"targeted":[73],"drugs.":[74],"We":[75],"following":[78],"two":[79],"optimization":[80,105,125],"criteria":[81],"(a)":[82],"generating":[83,94],"with":[86],"high":[87],"and":[89,92,114,132],"minimal":[90],"toxicity":[91],"(b)":[93],"multiple":[98],"parallel":[99],"avoiding":[102],"resistance.":[103],"The":[104,121],"problem":[106],"is":[107,127],"solved":[108],"using":[109],"set":[111],"cover":[112],"approach":[113],"sequential":[116],"search":[117],"hill":[118],"climbing":[119],"technique.":[120],"effectiveness":[122],"our":[124],"procedure":[126],"illustrated":[128],"both":[130],"synthetic":[131],"experimental":[133],"models.":[134]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
