{"id":"https://openalex.org/W2069329491","doi":"https://doi.org/10.1109/gensips.2011.6169471","title":"Modelling oxidative stress response pathways","display_name":"Modelling oxidative stress response pathways","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2069329491","doi":"https://doi.org/10.1109/gensips.2011.6169471","mag":"2069329491"},"language":"en","primary_location":{"id":"doi:10.1109/gensips.2011.6169471","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2011.6169471","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073514302","display_name":"Sriram Sridharan","orcid":"https://orcid.org/0000-0002-4811-8193"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sriram Sridharan","raw_affiliation_strings":["Electrical and Computer Engineering, Texas A and M University, College Station, TX, USA","Texas A & M University, Electrical and Computer Engineering, College Station, 77843-3128, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering, Texas A and M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A & M University, Electrical and Computer Engineering, College Station, 77843-3128, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010000375","display_name":"Ritwik Kumar Layek","orcid":"https://orcid.org/0000-0003-0044-2258"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritwik Layek","raw_affiliation_strings":["Electrical and Computer Engineering, Texas A and M University, College Station, TX, USA","Texas A & M University, Electrical and Computer Engineering, College Station, 77843-3128, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering, Texas A and M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A & M University, Electrical and Computer Engineering, College Station, 77843-3128, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045462352","display_name":"Aniruddha Datta","orcid":"https://orcid.org/0000-0003-1213-3807"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aniruddha Datta","raw_affiliation_strings":["Electrical and Computer Engineering, Texas A and M University, College Station, TX, USA","Texas A & M University, Electrical and Computer Engineering, College Station, 77843-3128, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering, Texas A and M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A & M University, Electrical and Computer Engineering, College Station, 77843-3128, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032872866","display_name":"Jijayanagaram Venkatraj","orcid":null},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jijayanagaram Venkatraj","raw_affiliation_strings":["Vet Integrative Biosciences, Texas A and M University, College Station, TX, USA","Texas A & M University, Vet Integrative Biosciences, College Station, 77843-4458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vet Integrative Biosciences, Texas A and M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A & M University, Vet Integrative Biosciences, College Station, 77843-4458, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":0.9941,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.78791549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"282","issue":null,"first_page":"166","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9876999855041504,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"Oxidative stress","score":0.8715270161628723},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.6627361178398132},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"Oxidative phosphorylation","score":0.536592960357666},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"Oxidative damage","score":0.4965084195137024},{"id":"https://openalex.org/keywords/signalling","display_name":"Signalling","score":0.4794294238090515},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4531673192977905},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.41765832901000977},{"id":"https://openalex.org/keywords/signalling-pathways","display_name":"Signalling pathways","score":0.41277679800987244},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.38305360078811646},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3778464198112488},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3736432194709778},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.360767662525177},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.24907782673835754},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18268126249313354},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14731088280677795}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8715270161628723},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6627361178398132},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.536592960357666},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.4965084195137024},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.4794294238090515},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4531673192977905},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41765832901000977},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.41277679800987244},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38305360078811646},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3778464198112488},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3736432194709778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.360767662525177},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24907782673835754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18268126249313354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14731088280677795}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/gensips.2011.6169471","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2011.6169471","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7699999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W629739200","https://openalex.org/W1980686102","https://openalex.org/W1993204994","https://openalex.org/W1995445783","https://openalex.org/W2009911964","https://openalex.org/W2049480816","https://openalex.org/W2053063855","https://openalex.org/W2062149493","https://openalex.org/W2090085803","https://openalex.org/W2093507774","https://openalex.org/W2108020239","https://openalex.org/W2117551116","https://openalex.org/W2134031315","https://openalex.org/W2146558971","https://openalex.org/W2149209973","https://openalex.org/W2155916115","https://openalex.org/W2164610579","https://openalex.org/W2530014580","https://openalex.org/W4388252848"],"related_works":["https://openalex.org/W2092427118","https://openalex.org/W2058539798","https://openalex.org/W2947741874","https://openalex.org/W1492131881","https://openalex.org/W2087709298","https://openalex.org/W2165025106","https://openalex.org/W4386778658","https://openalex.org/W2969844295","https://openalex.org/W2379481447","https://openalex.org/W2987447052"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1,18,51,75],"is":[2,85,90],"a":[3,81],"consequence":[4],"of":[5,12,73],"normal":[6,46],"cellular":[7,21,32],"metabolism.":[8],"The":[9],"effective":[10],"functioning":[11],"the":[13,20,45,79,97],"pathway":[14],"responding":[15],"to":[16,35,60],"oxidative":[17,24,50,74],"protects":[19],"DNA":[22],"against":[23],"damage":[25],"and":[26,41,54],"its":[27],"failure":[28],"can":[29],"induce":[30],"aberrant":[31],"behaviour":[33,89],"leading":[34,59],"diseases":[36],"such":[37],"as":[38],"neurodegenerative":[39],"disorders":[40],"cancer.":[42],"Thus,":[43],"understanding":[44],"signalling":[47,57],"present":[48],"in":[49],"response":[52,76],"pathways":[53,77],"determining":[55],"possible":[56],"alterations":[58],"disease":[61],"could":[62],"provide":[63],"us":[64],"with":[65,92],"useful":[66],"pointers":[67],"for":[68],"therapeutic":[69],"purposes.":[70],"Using":[71],"knowledge":[72],"from":[78,96],"literature,":[80],"Boolean":[82],"network":[83],"model":[84],"developed":[86],"whose":[87],"simulated":[88],"consistent":[91],"earlier":[93],"experimental":[94],"observations":[95],"literature.":[98]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}