{"id":"https://openalex.org/W2022733991","doi":"https://doi.org/10.1109/gensips.2011.6169462","title":"Network-assisted causal gene detection in genome-wide association studies: an improved module search algorithm","display_name":"Network-assisted causal gene detection in genome-wide association studies: an improved module search algorithm","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2022733991","doi":"https://doi.org/10.1109/gensips.2011.6169462","mag":"2022733991","pmid":"https://pubmed.ncbi.nlm.nih.gov/22898890"},"language":"en","primary_location":{"id":"doi:10.1109/gensips.2011.6169462","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2011.6169462","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3418601","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056121087","display_name":"Peilin Jia","orcid":"https://orcid.org/0000-0003-4523-4153"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peilin Jia","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","Department of Biomedical Informatics, Vanderbilt University School of Medicine,Nashville, TN 37232, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine,Nashville, TN 37232, USA#TAB#","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006688612","display_name":"Zhongming Zhao","orcid":"https://orcid.org/0000-0002-3477-0914"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongming Zhao","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA","Department of Biomedical Informatics, Vanderbilt University School of Medicine,Nashville, TN 37232, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine,Nashville, TN 37232, USA#TAB#","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":1.9336,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.85380767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"98","issue":null,"first_page":"131","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.6942880749702454},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6395621299743652},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5967462062835693},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.47706496715545654},{"id":"https://openalex.org/keywords/candidate-gene","display_name":"Candidate gene","score":0.4618339538574219},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.40861159563064575},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4079565405845642},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3933729827404022},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3385435938835144},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1997067630290985},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18967673182487488}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6942880749702454},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6395621299743652},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5967462062835693},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.47706496715545654},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4618339538574219},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40861159563064575},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4079565405845642},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3933729827404022},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3385435938835144},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1997067630290985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18967673182487488},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/gensips.2011.6169462","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2011.6169462","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"},{"id":"pmid:22898890","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22898890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE International Workshop on Genomic Signal Processing and Statistics : [proceedings]. IEEE International Workshop on Genomic Signal Processing and Statistics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3418601","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3418601","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Int Workshop Genomic Signal Process Stat","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3418601","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3418601","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Int Workshop Genomic Signal Process Stat","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.4099999964237213}],"awards":[{"id":"https://openalex.org/G390534284","display_name":null,"funder_award_id":"R03 DE022093","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1968744462","https://openalex.org/W1969129409","https://openalex.org/W1985900119","https://openalex.org/W1988404229","https://openalex.org/W2010576394","https://openalex.org/W2010768245","https://openalex.org/W2019024078","https://openalex.org/W2037324746","https://openalex.org/W2046434400","https://openalex.org/W2051816266","https://openalex.org/W2061921368","https://openalex.org/W2063684676","https://openalex.org/W2073544062","https://openalex.org/W2084974619","https://openalex.org/W2089843122","https://openalex.org/W2103606272","https://openalex.org/W2112947018","https://openalex.org/W2117446594","https://openalex.org/W2123774216","https://openalex.org/W2124307069","https://openalex.org/W2140164106","https://openalex.org/W2146653758","https://openalex.org/W2162960415","https://openalex.org/W2166963829"],"related_works":["https://openalex.org/W3132065130","https://openalex.org/W2594299395","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W1486217206","https://openalex.org/W1992310781"],"abstract_inverted_index":{"The":[0],"recent":[1],"success":[2],"of":[3,13,27,59,71,94,104,113,121,176,217],"genome-wide":[4],"association":[5,199],"(GWA)":[6],"studies":[7],"has":[8,205],"greatly":[9],"expanded":[10],"our":[11,180,214],"understanding":[12],"many":[14],"complex":[15,114],"diseases":[16],"by":[17,128,142,188],"delivering":[18],"previously":[19],"unknown":[20],"loci":[21],"and":[22,44],"genes.":[23,73],"A":[24],"large":[25],"number":[26],"GWAS":[28,64,157],"datasets":[29],"have":[30,193],"already":[31],"been":[32,194],"made":[33],"available,":[34],"with":[35],"more":[36,184],"being":[37],"generated.":[38],"To":[39],"explore":[40],"the":[41,68,81,92,106,111,118,125,132,138,146,151,163,174,189,197,209,218],"underlying":[42],"moderate":[43],"weak":[45],"signals,":[46],"we":[47,99,123,182],"recently":[48],"developed":[49],"a":[50,85,156],"network-based":[51],"dense":[52],"module":[53,220],"search":[54,79],"(DMS)":[55],"method":[56],"for":[57,80,159],"identification":[58],"disease":[60],"candidate":[61,170,185],"genes":[62,171,186,221],"from":[63],"datasets,":[65],"leveraging":[66],"on":[67,117],"joint":[69],"effect":[70],"multiple":[72],"DMS":[74,153,165,191,211],"is":[75],"designed":[76],"to":[77,109,136],"dynamically":[78],"best":[82],"nodes":[83,144],"in":[84,145,155,196,227],"step-wise":[86],"fashion":[87],"and,":[88],"thus,":[89],"could":[90,167],"overcome":[91],"limitation":[93],"pre-defined":[95],"gene":[96],"sets.":[97],"Here,":[98],"propose":[100],"an":[101],"improved":[102,124,164],"version":[103,120],"DMS,":[105,108,122],"topologically-adjusted":[107,152,190],"facilitate":[110],"analysis":[112,216],"diseases.":[115],"Building":[116],"previous":[119,198],"randomization":[126],"process":[127],"taking":[129],"into":[130],"account":[131],"topological":[133],"character,":[134],"aiming":[135],"adjust":[137],"bias":[139],"potentially":[140],"caused":[141],"high-degree":[143,177],"whole":[147],"network.":[148],"We":[149,161],"demonstrated":[150],"algorithm":[154,192,204],"dataset":[158],"schizophrenia.":[160],"found":[162,183],"strategy":[166],"effectively":[168],"identify":[169],"while":[172],"reducing":[173],"burden":[175],"nodes.":[178],"In":[179],"evaluation,":[181],"identified":[187],"reported":[195],"studies,":[200],"suggesting":[201],"this":[202],"new":[203],"better":[206],"performance":[207],"than":[208],"unweighted":[210],"algorithm.":[212],"Finally,":[213],"functional":[215],"top":[219],"revealed":[222],"that":[223],"they":[224],"are":[225],"enriched":[226],"immune-related":[228],"pathways.":[229]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
