{"id":"https://openalex.org/W1964448159","doi":"https://doi.org/10.1109/gensips.2011.6169444","title":"Pathway analysis in the context of Bayesian networks - mathematical modeling of master and canalizing genes","display_name":"Pathway analysis in the context of Bayesian networks - mathematical modeling of master and canalizing genes","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W1964448159","doi":"https://doi.org/10.1109/gensips.2011.6169444","mag":"1964448159"},"language":"en","primary_location":{"id":"doi:10.1109/gensips.2011.6169444","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2011.6169444","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072782768","display_name":"Chen Zhao","orcid":"https://orcid.org/0000-0001-7270-7580"},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I4210104856","display_name":"Phoenix (United States)","ror":"https://ror.org/01ggenr10","country_code":"US","type":"company","lineage":["https://openalex.org/I4210104856"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Zhao","raw_affiliation_strings":["Computational Biology Division, Translational Genomics Research Institute Phoenix, Phoenix, AZ, USA","Department of Electrical and Computer Engineering, Texas A and M University, College Station, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Division, Translational Genomics Research Institute Phoenix, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I1284308235","https://openalex.org/I4210104856"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A and M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079620688","display_name":"Ivan Ivanov","orcid":"https://orcid.org/0000-0002-5323-8325"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Ivanov","raw_affiliation_strings":["Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007353982","display_name":"Michael Bittner","orcid":"https://orcid.org/0000-0003-4293-930X"},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I4210104856","display_name":"Phoenix (United States)","ror":"https://ror.org/01ggenr10","country_code":"US","type":"company","lineage":["https://openalex.org/I4210104856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Bittner","raw_affiliation_strings":["Computational Biology Division, Translational Genomics Research Institute Phoenix, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Division, Translational Genomics Research Institute Phoenix, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I1284308235","https://openalex.org/I4210104856"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112221423","display_name":"Edward R. Dougherty","orcid":null},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4210104856","display_name":"Phoenix (United States)","ror":"https://ror.org/01ggenr10","country_code":"US","type":"company","lineage":["https://openalex.org/I4210104856"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward R. Dougherty","raw_affiliation_strings":["Computational Biology Division, Translational Genomics Research Institute Phoenix, Phoenix, AZ, USA","Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","Department of Electrical and Computer Engineering, Texas A and M University, College Station, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Division, Translational Genomics Research Institute Phoenix, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I1284308235","https://openalex.org/I4210104856"]},{"raw_affiliation_string":"Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A and M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09554569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"64","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.665436863899231},{"id":"https://openalex.org/keywords/bayesian-network","display_name":"Bayesian network","score":0.6388715505599976},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5940026044845581},{"id":"https://openalex.org/keywords/dynamic-bayesian-network","display_name":"Dynamic Bayesian network","score":0.5019347667694092},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48877188563346863},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4867391586303711},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4509087800979614},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4279177188873291},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3833698332309723},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3524342179298401},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1862800419330597}],"concepts":[{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.665436863899231},{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.6388715505599976},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5940026044845581},{"id":"https://openalex.org/C82142266","wikidata":"https://www.wikidata.org/wiki/Q3456604","display_name":"Dynamic Bayesian network","level":3,"score":0.5019347667694092},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48877188563346863},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4867391586303711},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4509087800979614},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4279177188873291},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3833698332309723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3524342179298401},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1862800419330597},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/gensips.2011.6169444","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2011.6169444","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2094902224","https://openalex.org/W2104862630","https://openalex.org/W2115350121"],"related_works":["https://openalex.org/W1964038743","https://openalex.org/W2578973671","https://openalex.org/W2215058820","https://openalex.org/W2945000716","https://openalex.org/W2097663773","https://openalex.org/W1602184117","https://openalex.org/W2564827943","https://openalex.org/W2511198839","https://openalex.org/W1966557338","https://openalex.org/W2366931106"],"abstract_inverted_index":{"We":[0,61],"utilize":[1],"a":[2],"tree-structured":[3],"Bayesian":[4,75],"network":[5],"to":[6],"characterize":[7],"and":[8,11,52],"detect":[9],"master":[10],"canalizing":[12,30],"genes":[13,21,31],"via":[14],"the":[15,34,45,50,53,71,74],"coefficient":[16],"of":[17,27,36,73],"determination":[18],"(CoD).":[19],"Master":[20],"possess":[22],"strong":[23],"regulation":[24,35],"over":[25,33],"groups":[26],"genes,":[28],"whereas":[29],"take":[32],"large":[37],"cohorts":[38],"under":[39],"certain":[40],"cell":[41],"conditions.":[42],"While":[43],"related,":[44],"two":[46],"concepts":[47],"are":[48],"not":[49],"same":[51],"analytic":[54],"measures":[55],"we":[56],"employ":[57],"reveal":[58],"that":[59],"difference.":[60],"also":[62],"consider":[63],"hypothesis":[64],"testing":[65],"for":[66],"successful":[67],"drug":[68],"intervention":[69],"in":[70],"framework":[72],"model.":[76]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}