{"id":"https://openalex.org/W2066214649","doi":"https://doi.org/10.1109/gensips.2011.6169439","title":"Assessing the efficacy of molecularly targeted agents by using Kalman filter","display_name":"Assessing the efficacy of molecularly targeted agents by using Kalman filter","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2066214649","doi":"https://doi.org/10.1109/gensips.2011.6169439","mag":"2066214649"},"language":"en","primary_location":{"id":"doi:10.1109/gensips.2011.6169439","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2011.6169439","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063982441","display_name":"Xiangfang Li","orcid":"https://orcid.org/0000-0003-0334-4733"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangfang Li","raw_affiliation_strings":["Department of ECE, Texas A and M University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of ECE, Texas A and M University, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085031765","display_name":"Lijun Qian","orcid":"https://orcid.org/0000-0003-1577-3359"},"institutions":[{"id":"https://openalex.org/I250520410","display_name":"Prairie View A&M University","ror":"https://ror.org/0449kf092","country_code":"US","type":"education","lineage":["https://openalex.org/I250520410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lijun Qian","raw_affiliation_strings":["Department of ECE, Prairie View A and M University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of ECE, Prairie View A and M University, USA","institution_ids":["https://openalex.org/I250520410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007353982","display_name":"Michael Bittner","orcid":"https://orcid.org/0000-0003-4293-930X"},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Bittner","raw_affiliation_strings":["Translational Genomics Research Institute Phoenix, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Genomics Research Institute Phoenix, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112221423","display_name":"Edward R. Dougherty","orcid":null},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward R. Dougherty","raw_affiliation_strings":["Department of ECE, Texas A and M University, USA","Translational Genomics Research Institute and Department of Bioinformatics and Computational Biology, University of Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of ECE, Texas A and M University, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Translational Genomics Research Institute and Department of Bioinformatics and Computational Biology, University of Texas, USA","institution_ids":["https://openalex.org/I1284308235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9941,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.78656978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"50","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"Pharmacodynamics","score":0.6791523098945618},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6405477523803711},{"id":"https://openalex.org/keywords/kalman-filter","display_name":"Kalman filter","score":0.6299753189086914},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.5278463363647461},{"id":"https://openalex.org/keywords/dosing","display_name":"Dosing","score":0.4695361852645874},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.4655158519744873},{"id":"https://openalex.org/keywords/drug-action","display_name":"Drug action","score":0.4231330156326294},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40784990787506104},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2633741497993469},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.19698849320411682},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12717515230178833},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.09103897213935852}],"concepts":[{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6791523098945618},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6405477523803711},{"id":"https://openalex.org/C157286648","wikidata":"https://www.wikidata.org/wiki/Q846780","display_name":"Kalman filter","level":2,"score":0.6299753189086914},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5278463363647461},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.4695361852645874},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4655158519744873},{"id":"https://openalex.org/C86380466","wikidata":"https://www.wikidata.org/wiki/Q5308872","display_name":"Drug action","level":3,"score":0.4231330156326294},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40784990787506104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2633741497993469},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.19698849320411682},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12717515230178833},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09103897213935852},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/gensips.2011.6169439","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2011.6169439","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/8","display_name":"Decent work and economic growth","score":0.550000011920929}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1537786506","https://openalex.org/W1554441203","https://openalex.org/W1650538669","https://openalex.org/W1998048991","https://openalex.org/W2025576391","https://openalex.org/W2074410116","https://openalex.org/W2078865702","https://openalex.org/W2128789136","https://openalex.org/W2171497508"],"related_works":["https://openalex.org/W1782647748","https://openalex.org/W4245706755","https://openalex.org/W4254948725","https://openalex.org/W2596011850","https://openalex.org/W4285170202","https://openalex.org/W2497992324","https://openalex.org/W4289443666","https://openalex.org/W2770752843","https://openalex.org/W2412806641","https://openalex.org/W4213271907"],"abstract_inverted_index":{"A":[0],"novel":[1],"preclinical":[2,80],"model":[3],"combining":[4],"experimental":[5,92],"methods":[6],"and":[7,18],"theoretical":[8],"analysis":[9,30],"is":[10,76],"proposed":[11],"to":[12,35,61,94],"investigate":[13],"the":[14,32,38,64],"mechanism":[15],"of":[16,22,26,31,41,66],"action":[17],"identify":[19],"pharmacodynamic":[20],"characteristic":[21],"a":[23,73],"drug.":[24],"Instead":[25],"fixed":[27],"time":[28,39],"point":[29],"drug":[33,36,42],"exposure":[34],"effect,":[37],"course":[40],"effect":[43],"for":[44,89],"different":[45],"doses":[46],"are":[47,69],"quantitatively":[48],"studied":[49],"on":[50],"cell":[51],"line-based":[52],"platforms":[53],"using":[54],"Kalman":[55],"filter,":[56],"where":[57],"tumor":[58],"cells'":[59],"responses":[60],"drugs":[62],"through":[63],"use":[65],"fluorescent":[67],"reporters":[68],"sampled":[70],"frequently":[71],"over":[72],"time-course.":[74],"It":[75],"expected":[77],"that":[78],"such":[79],"study":[81],"will":[82],"provide":[83],"valuable":[84],"suggestions":[85],"about":[86],"dosing":[87],"regimens":[88],"in":[90],"vivo":[91],"stage":[93],"increase":[95],"productivity.":[96]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}