{"id":"https://openalex.org/W2016849512","doi":"https://doi.org/10.1109/gensips.2009.5174329","title":"Characterization of systems-level organization through mining large-scale genetic interaction networks","display_name":"Characterization of systems-level organization through mining large-scale genetic interaction networks","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W2016849512","doi":"https://doi.org/10.1109/gensips.2009.5174329","mag":"2016849512"},"language":"en","primary_location":{"id":"doi:10.1109/gensips.2009.5174329","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2009.5174329","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Workshop on Genomic Signal Processing and Statistics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023317082","display_name":"Jeremy Bellay","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137981","display_name":"Land Stewardship Project","ror":"https://ror.org/04khvrj77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137981"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeremy Bellay","raw_affiliation_strings":["Department of Computer Science and Engineering, 200 Union St. SE Minneapolis, MN 55455, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, 200 Union St. SE Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I4210137981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088198398","display_name":"Benjamin VanderSluis","orcid":"https://orcid.org/0000-0002-0299-5617"},"institutions":[{"id":"https://openalex.org/I4210137981","display_name":"Land Stewardship Project","ror":"https://ror.org/04khvrj77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137981"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin VanderSluis","raw_affiliation_strings":["Department of Computer Science and Engineering, 200 Union St. SE Minneapolis, MN 55455, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, 200 Union St. SE Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I4210137981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011307269","display_name":"Yungil Kim","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yungil Kim","raw_affiliation_strings":["Department of Electrical and Computer Engineering, 200 Union St. SE Minneapolis, MN 55455, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, 200 Union St. SE Minneapolis, MN 55455, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029174985","display_name":"Sunayan Bandyopadhyay","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137981","display_name":"Land Stewardship Project","ror":"https://ror.org/04khvrj77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137981"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunayan Bandyopadhyay","raw_affiliation_strings":["Department of Computer Science and Engineering, 200 Union St. SE Minneapolis, MN 55455, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, 200 Union St. SE Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I4210137981"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022226374","display_name":"Chad L. Myers","orcid":"https://orcid.org/0000-0002-1026-5972"},"institutions":[{"id":"https://openalex.org/I4210137981","display_name":"Land Stewardship Project","ror":"https://ror.org/04khvrj77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137981"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad L. Myers","raw_affiliation_strings":["Department of Computer Science and Engineering, 200 Union St. SE Minneapolis, MN 55455, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, 200 Union St. SE Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I4210137981"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023317082"],"corresponding_institution_ids":["https://openalex.org/I4210137981"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09830469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modularity","display_name":"Modularity (biology)","score":0.6986718773841858},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6468635201454163},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6438602209091187},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.4634425938129425},{"id":"https://openalex.org/keywords/gene-interaction","display_name":"Gene interaction","score":0.45305413007736206},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4529626667499542},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4221319258213043},{"id":"https://openalex.org/keywords/complex-network","display_name":"Complex network","score":0.4211907386779785},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3570544123649597},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.33842936158180237},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3357533812522888},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2700995206832886},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17016083002090454},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15178725123405457}],"concepts":[{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.6986718773841858},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6468635201454163},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6438602209091187},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.4634425938129425},{"id":"https://openalex.org/C2991772755","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Gene interaction","level":3,"score":0.45305413007736206},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4529626667499542},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4221319258213043},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.4211907386779785},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3570544123649597},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.33842936158180237},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3357533812522888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2700995206832886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17016083002090454},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15178725123405457},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/gensips.2009.5174329","is_oa":false,"landing_page_url":"https://doi.org/10.1109/gensips.2009.5174329","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Workshop on Genomic Signal Processing and Statistics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5600000023841858,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1986017739","https://openalex.org/W1999382407","https://openalex.org/W2011242261","https://openalex.org/W2032664706","https://openalex.org/W2070829661","https://openalex.org/W2084377907","https://openalex.org/W2084619201","https://openalex.org/W2098135462","https://openalex.org/W2108480332","https://openalex.org/W2120865735","https://openalex.org/W2130139983","https://openalex.org/W2130907642","https://openalex.org/W2140948740","https://openalex.org/W2150749732","https://openalex.org/W2159460045","https://openalex.org/W2167869241"],"related_works":["https://openalex.org/W1917559760","https://openalex.org/W2011882979","https://openalex.org/W2057306547","https://openalex.org/W2386800983","https://openalex.org/W2767490506","https://openalex.org/W2084801408","https://openalex.org/W2127864418","https://openalex.org/W1511239490","https://openalex.org/W2149060064","https://openalex.org/W3010242829"],"abstract_inverted_index":{"Understanding":[0],"cellular":[1],"organization":[2],"and":[3,25,89,123,154,176,179,192,206,213],"function":[4],"on":[5],"a":[6,10,86,103,110,131],"global":[7,187],"scale":[8],"is":[9],"central":[11],"challenge":[12],"in":[13,81,85,95,200,210],"systems":[14],"biology.":[15],"Recent":[16],"high-throughput":[17],"experimental":[18],"technology":[19],"has":[20,47,58],"produced":[21],"datasets":[22],"capturing":[23],"physical":[24,44,97],"genetic":[26,69,120,137,151,177],"interactions":[27,72,117],"among":[28],"various":[29],"components":[30],"of":[31,43,63,68,116,130,134,150,164,183,189,203],"the":[32,41,52,64,96,135,147,162,172,181,201],"cell,":[33],"which":[34],"contain":[35],"clues":[36],"about":[37],"systems-level":[38],"organization.":[39],"While":[40],"analysis":[42,62],"interaction":[45,98,138,152],"networks":[46,153,205],"received":[48],"significant":[49],"attention":[50,57],"from":[51,118],"bioinformatics":[53],"community,":[54],"relatively":[55],"little":[56],"been":[59],"devoted":[60],"to":[61,93],"more":[65],"general":[66],"phenomenon":[67],"interaction.":[70],"Genetic":[71],"are":[73,90,124,216],"generally":[74],"defined":[75],"as":[76],"cases":[77],"where":[78,208],"simultaneous":[79],"mutations":[80],"multiple":[82],"genes":[83],"result":[84],"surprising":[87],"phenotype,":[88],"highly":[91,113],"complementary":[92],"information":[94],"network.":[99,139],"In":[100],"collaboration":[101],"with":[102],"yeast":[104,136],"genetics":[105],"lab,":[106],"we":[107,169],"have":[108],"developed":[109],"strategy":[111],"for":[112,186],"quantitative":[114],"characterization":[115,188],"synthetic":[119],"arrays":[121],"(SGA),":[122],"now":[125],"getting":[126],"our":[127],"first":[128],"view":[129],"large":[132],"fraction":[133],"We":[140,194],"will":[141,170,195],"introduce":[142],"several":[143,156,197],"fundamental":[144],"concepts":[145],"supporting":[146],"emerging":[148],"direction":[149],"describe":[155,180],"striking":[157],"properties":[158],"revealed":[159],"by":[160],"mining":[161,215],"structure":[163,191],"such":[165,204],"networks.":[166],"For":[167],"example,":[168],"discuss":[171,207],"connection":[173],"between":[174],"modularity":[175],"interactions,":[178],"potential":[182],"these":[184],"data":[185,214],"network":[190],"robustness.":[193],"highlight":[196],"open":[198],"problems":[199],"interpretation":[202],"innovations":[209],"machine":[211],"learning":[212],"particularly":[217],"relevant.":[218]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}