{"id":"https://openalex.org/W2048520934","doi":"https://doi.org/10.1109/fskd.2014.6980886","title":"Qualitative modeling and analysis of the indoleamine 2,3-dioxygenase regulatory network in homeostasis and disease","display_name":"Qualitative modeling and analysis of the indoleamine 2,3-dioxygenase regulatory network in homeostasis and disease","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2048520934","doi":"https://doi.org/10.1109/fskd.2014.6980886","mag":"2048520934"},"language":"en","primary_location":{"id":"doi:10.1109/fskd.2014.6980886","is_oa":false,"landing_page_url":"https://doi.org/10.1109/fskd.2014.6980886","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 11th International Conference on Fuzzy Systems and Knowledge Discovery (FSKD)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075356158","display_name":"Kashif Asghar","orcid":"https://orcid.org/0000-0002-6855-5008"},"institutions":[{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Kashif Asghar","raw_affiliation_strings":["Atta-ur-Rehman School of Applied Biosciences, National University of Science & Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atta-ur-Rehman School of Applied Biosciences, National University of Science & Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048174901","display_name":"Jamil Ahmed","orcid":"https://orcid.org/0000-0002-4573-5196"},"institutions":[{"id":"https://openalex.org/I312958679","display_name":"National University of Science and Technology","ror":"https://ror.org/02kesvt12","country_code":"ZW","type":"education","lineage":["https://openalex.org/I312958679"]},{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK","ZW"],"is_corresponding":false,"raw_author_name":"Jamil Ahmed","raw_affiliation_strings":["Research Center for Modeling & Simulation, National University of Science & Technology(NUST), Islamabad, Pakistan","Research Center for Modeling & Simulation, National University of Science & Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Modeling & Simulation, National University of Science & Technology(NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]},{"raw_affiliation_string":"Research Center for Modeling & Simulation, National University of Science & Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I312958679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053020946","display_name":"Javaria Ashraf","orcid":null},"institutions":[{"id":"https://openalex.org/I312958679","display_name":"National University of Science and Technology","ror":"https://ror.org/02kesvt12","country_code":"ZW","type":"education","lineage":["https://openalex.org/I312958679"]},{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK","ZW"],"is_corresponding":false,"raw_author_name":"Javaria Ashraf","raw_affiliation_strings":["Research Center for Modeling & Simulation, National University of Science & Technology(NUST), Islamabad, Pakistan","Research Center for Modeling & Simulation, National University of Science & Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Modeling & Simulation, National University of Science & Technology(NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]},{"raw_affiliation_string":"Research Center for Modeling & Simulation, National University of Science & Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I312958679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001004081","display_name":"Amjad Ali","orcid":"https://orcid.org/0000-0002-0486-4661"},"institutions":[{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Amjad Ali","raw_affiliation_strings":["Atta-ur-Rehman School of Applied Biosciences, National University of Science & Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atta-ur-Rehman School of Applied Biosciences, National University of Science & Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071485187","display_name":"Hussnain Ahmed Janjua","orcid":"https://orcid.org/0000-0002-8247-8248"},"institutions":[{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Hussnain Ahmed Janjua","raw_affiliation_strings":["Atta-ur-Rehman School of Applied Biosciences, National University of Science & Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atta-ur-Rehman School of Applied Biosciences, National University of Science & Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078623000","display_name":"Sheeba Murad","orcid":null},"institutions":[{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sheeba Murad","raw_affiliation_strings":["Atta-ur-Rehman School of Applied Biosciences, National University of Science & Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atta-ur-Rehman School of Applied Biosciences, National University of Science & Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"508","last_page":"512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.9725000262260437,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indoleamine-2-3-dioxygenase","display_name":"Indoleamine 2,3-dioxygenase","score":0.7989319562911987},{"id":"https://openalex.org/keywords/kynurenine","display_name":"Kynurenine","score":0.6747229099273682},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"Autoimmunity","score":0.6729843616485596},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5851104259490967},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5797607898712158},{"id":"https://openalex.org/keywords/homeostasis","display_name":"Homeostasis","score":0.5703465342521667},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.5658702254295349},{"id":"https://openalex.org/keywords/regulatory-t-cell","display_name":"Regulatory T cell","score":0.5205329656600952},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5041161775588989},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.48367103934288025},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4366368055343628},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4005904197692871},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3091357350349426},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.26934814453125},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1814153790473938},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.14252954721450806},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12590563297271729},{"id":"https://openalex.org/keywords/tryptophan","display_name":"Tryptophan","score":0.10308274626731873},{"id":"https://openalex.org/keywords/il-2-receptor","display_name":"IL-2 receptor","score":0.08586588501930237},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07226291298866272}],"concepts":[{"id":"https://openalex.org/C83478079","wikidata":"https://www.wikidata.org/wiki/Q908221","display_name":"Indoleamine 2,3-dioxygenase","level":4,"score":0.7989319562911987},{"id":"https://openalex.org/C2777503454","wikidata":"https://www.wikidata.org/wiki/Q415768","display_name":"Kynurenine","level":4,"score":0.6747229099273682},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6729843616485596},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5851104259490967},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5797607898712158},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5703465342521667},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5658702254295349},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.5205329656600952},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5041161775588989},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48367103934288025},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4366368055343628},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4005904197692871},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3091357350349426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26934814453125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1814153790473938},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.14252954721450806},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12590563297271729},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.10308274626731873},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.08586588501930237},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07226291298866272},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/fskd.2014.6980886","is_oa":false,"landing_page_url":"https://doi.org/10.1109/fskd.2014.6980886","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 11th International Conference on Fuzzy Systems and Knowledge Discovery (FSKD)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W249159571","https://openalex.org/W1553444759","https://openalex.org/W1674446916","https://openalex.org/W1834981029","https://openalex.org/W1949097444","https://openalex.org/W1964282557","https://openalex.org/W1969078685","https://openalex.org/W1973251492","https://openalex.org/W1991392411","https://openalex.org/W2018234318","https://openalex.org/W2028223005","https://openalex.org/W2032980904","https://openalex.org/W2035729479","https://openalex.org/W2053485564","https://openalex.org/W2061610085","https://openalex.org/W2069360248","https://openalex.org/W2094579915","https://openalex.org/W2103565638","https://openalex.org/W2127053639","https://openalex.org/W2127903252","https://openalex.org/W2136280424","https://openalex.org/W2136906788","https://openalex.org/W3021657088"],"related_works":["https://openalex.org/W1988960013","https://openalex.org/W4210976760","https://openalex.org/W4321485359","https://openalex.org/W2096287500","https://openalex.org/W2560042487","https://openalex.org/W2186316345","https://openalex.org/W3027247668","https://openalex.org/W4283574129","https://openalex.org/W2313033156","https://openalex.org/W2048520934"],"abstract_inverted_index":{"Indoleamine":[0],"2,3-dioxygenase":[1],"(IDO)":[2],"has":[3],"key":[4],"role":[5,100],"in":[6,101,126,139,180],"immune":[7],"regulation":[8],"and":[9,25,39,65,75,117,149,166,190],"it":[10],"acts":[11],"as":[12,29],"a":[13,47,181],"constituent":[14],"of":[15,50,60,80,96,104,108,114,120,135,147,164,183],"the":[16,35,57,63,78,87,91,94,102,109,145,160],"inflammatory":[17],"reaction":[18],"allied":[19],"with":[20],"infection,":[21],"allergic":[22],"diseases,":[23],"autoimmunity":[24],"cancer.":[26],"IDO":[27,97,148,167],"function":[28],"an":[30],"immunosuppressive":[31],"enzyme,":[32],"which":[33],"degrades":[34],"tryptophan":[36],"into":[37],"kynurenine":[38],"other":[40,82],"downstream":[41],"metabolites.":[42],"Interferon":[43],"gamma":[44],"(IFN-\u03b3)":[45],"is":[46,56,153,170],"potent":[48],"inducer":[49],"IDO.":[51,61],"Transforming":[52],"growth":[53],"factor-beta":[54],"(TGF-\u03b2)":[55],"negative":[58],"regulator":[59],"Both":[62],"TGF-\u03b2":[64,76,118,150,169],"IFN-\u03b3":[66,74,116,152,165],"have":[67],"opposite":[68],"effects":[69],"on":[70],"various":[71],"cellular":[72],"functions.":[73],"inhibit":[77],"activity":[79],"each":[81],"through":[83],"different":[84],"pathways.":[85],"In":[86],"pathological":[88],"state":[89,158],"when":[90],"homeostasis":[92,146],"disturb,":[93],"impairment":[95],"provides":[98],"significant":[99],"pathogenesis":[103],"disease.":[105],"The":[106,142,156],"modeling":[107],"Gene":[110],"regulatory":[111],"network":[112],"(GRN)":[113],"IDO,":[115],"using":[119],"Ren\u00e9":[121],"Thomas":[122],"Formalism,":[123],"help":[124],"us":[125],"understanding":[127],"their":[128],"dynamical":[129],"behaviors.":[130],"We":[131],"observe":[132],"two":[133],"types":[134],"steady":[136],"states":[137],"behaviors":[138],"this":[140],"study.":[141],"cycle":[143],"shows":[144,159],"while":[151,168],"inactive":[154],"(silent).":[155],"stable":[157],"high":[161],"expression":[162],"levels":[163],"silent.":[171],"These":[172],"findings":[173],"recognized":[174],"prospective":[175],"novel":[176],"targets":[177],"for":[178],"therapy":[179],"range":[182],"clinical":[184],"conditions,":[185],"including,":[186],"inflammation,":[187],"tumor":[188],"resistance":[189],"autoimmunity.":[191]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
