{"id":"https://openalex.org/W2769595542","doi":"https://doi.org/10.1109/esscirc.2017.8094602","title":"A 64\u00d764 high-density redox amplified coulostatic discharge-based biosensor array in 180nm CMOS","display_name":"A 64\u00d764 high-density redox amplified coulostatic discharge-based biosensor array in 180nm CMOS","publication_year":2017,"publication_date":"2017-09-01","ids":{"openalex":"https://openalex.org/W2769595542","doi":"https://doi.org/10.1109/esscirc.2017.8094602","mag":"2769595542"},"language":"en","primary_location":{"id":"doi:10.1109/esscirc.2017.8094602","is_oa":false,"landing_page_url":"https://doi.org/10.1109/esscirc.2017.8094602","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESSCIRC 2017 - 43rd IEEE European Solid State Circuits Conference","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103197083","display_name":"Alexander Sun","orcid":"https://orcid.org/0000-0003-2374-2069"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Sun","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018941756","display_name":"Enrique Alvarez-Fontecilla","orcid":"https://orcid.org/0000-0002-2446-0445"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Enrique Alvarez-Fontecilla","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104027059","display_name":"A. G. Venkatesh","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. G. Venkatesh","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073197979","display_name":"Eliah Aronoff\u2010Spencer","orcid":"https://orcid.org/0000-0002-6279-5027"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eliah Aronoff-Spencer","raw_affiliation_strings":["School of Medicine, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040823901","display_name":"Drew A. Hall","orcid":"https://orcid.org/0000-0003-0674-074X"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drew A. Hall","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":2.7002,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.89713914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":null,"first_page":"368","last_page":"371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cmos","display_name":"CMOS","score":0.68565434217453},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.6325741410255432},{"id":"https://openalex.org/keywords/analyte","display_name":"Analyte","score":0.6045035719871521},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.6040022969245911},{"id":"https://openalex.org/keywords/sensor-array","display_name":"Sensor array","score":0.550796627998352},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.5240969061851501},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.4991185665130615},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3471142649650574},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.27240055799484253},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.15093573927879333}],"concepts":[{"id":"https://openalex.org/C46362747","wikidata":"https://www.wikidata.org/wiki/Q173431","display_name":"CMOS","level":2,"score":0.68565434217453},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.6325741410255432},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.6045035719871521},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6040022969245911},{"id":"https://openalex.org/C66251956","wikidata":"https://www.wikidata.org/wiki/Q7451086","display_name":"Sensor array","level":2,"score":0.550796627998352},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.5240969061851501},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.4991185665130615},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3471142649650574},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27240055799484253},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15093573927879333},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/esscirc.2017.8094602","is_oa":false,"landing_page_url":"https://doi.org/10.1109/esscirc.2017.8094602","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESSCIRC 2017 - 43rd IEEE European Solid State Circuits Conference","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.44999998807907104}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1599358189","https://openalex.org/W1972889821","https://openalex.org/W1990874746","https://openalex.org/W1993723732","https://openalex.org/W1999967778","https://openalex.org/W2000763754","https://openalex.org/W2075721554","https://openalex.org/W2182654896","https://openalex.org/W2288373993","https://openalex.org/W2325229160","https://openalex.org/W2594517589"],"related_works":["https://openalex.org/W2082761856","https://openalex.org/W2046430340","https://openalex.org/W2322026400","https://openalex.org/W2383021773","https://openalex.org/W4206515393","https://openalex.org/W1990396141","https://openalex.org/W2056670287","https://openalex.org/W1929958295","https://openalex.org/W2226641048","https://openalex.org/W2141022875"],"abstract_inverted_index":{"This":[0],"paper":[1],"describes":[2],"the":[3,30,58,77,90,96,121,130,148,156],"design":[4],"of":[5,29,95,112,125,159],"a":[6,39,45,51,69,166],"high-density":[7],"4,096-pixel":[8],"electrochemical":[9],"biosensor":[10],"array":[11,31],"in":[12],"180nm":[13],"CMOS":[14,47],"for":[15,60],"biomedical":[16],"applications":[17],"that":[18],"require":[19],"multiple":[20],"analyte":[21],"detection":[22,158],"from":[23,128],"small":[24],"(5\u03bcL)":[25],"samples.":[26],"Each":[27],"pixel":[28],"contains":[32],"an":[33,107],"exposed":[34],"45\u00d745\u03bcm2interdigitated":[35],"micro-electrode":[36],"surrounded":[37],"by":[38],"~9pL":[40],"nanowell":[41],"fabricated":[42],"using":[43,116],"only":[44],"standard":[46],"process":[48],"along":[49],"with":[50,102,120,150],"simple":[52],"electroless":[53],"gold":[54],"plating":[55],"procedure":[56],"without":[57,146],"need":[59],"further":[61],"post":[62],"processing.":[63],"Directly":[64],"underneath":[65],"each":[66],"transducer":[67],"is":[68,136,161],"complete":[70,167],"ultra-low-leakage":[71],"(sub-fA)":[72],"readout":[73],"circuitry,":[74],"which":[75],"leverages":[76],"Coulostatic":[78],"Discharge":[79],"sensing":[80],"technique":[81],"and":[82,92],"interdigitated":[83],"electrode":[84],"(IDE)":[85],"geometry":[86],"to":[87,138],"minimize":[88],"both":[89],"complexity":[91],"overall":[93],"size":[94],"array.":[97],"By":[98],"evaluating":[99],"IDE":[100],"designs":[101],"different":[103],"feature":[104],"sizes":[105],"(2-5\u03bcm),":[106],"average":[108],"maximum":[109],"amplification":[110],"factor":[111],"10.5x":[113],"was":[114],"achieved":[115],"redox":[117],"cycling":[118],"coupled":[119],"higher":[122],"collection":[123],"efficiency":[124],"trenches":[126],"formed":[127],"opening":[129],"passivation.":[131],"The":[132],"array's":[133],"sensor":[134,143],"density":[135],"comparable":[137],"or":[139,153],"better":[140],"than":[141],"state-of-the-art":[142],"arrays,":[144],"all":[145],"augmenting":[147],"sensors":[149],"additional":[151],"materials":[152],"structures.":[154],"Using":[155],"array,":[157],"anti-Rubella":[160],"demonstrated":[162],"as":[163],"progress":[164],"towards":[165],"vaccination":[168],"panel.":[169]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}