{"id":"https://openalex.org/W7118003613","doi":"https://doi.org/10.1109/enc68268.2025.11311911","title":"Central Dogma of Biology: Inclusion, Educational Game, and AI Technology in the University Classroom","display_name":"Central Dogma of Biology: Inclusion, Educational Game, and AI Technology in the University Classroom","publication_year":2025,"publication_date":"2025-11-10","ids":{"openalex":"https://openalex.org/W7118003613","doi":"https://doi.org/10.1109/enc68268.2025.11311911"},"language":null,"primary_location":{"id":"doi:10.1109/enc68268.2025.11311911","is_oa":false,"landing_page_url":"https://doi.org/10.1109/enc68268.2025.11311911","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 Mexican International Conference on Computer Science (ENC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091670411","display_name":"Juli\u00e1n A. Yunes-Rojas","orcid":null},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Juli\u00e1n Alejandro Yunes-Rojas","raw_affiliation_strings":["Tecnologico de Monterrey. School of Engineering and Sciences,Puebla,M&#x00E9;xico"],"affiliations":[{"raw_affiliation_string":"Tecnologico de Monterrey. School of Engineering and Sciences,Puebla,M&#x00E9;xico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041886072","display_name":"Jos\u00e9 M. Nieto-Jalil","orcid":"https://orcid.org/0000-0001-9908-2621"},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M. Nieto-Jalil","raw_affiliation_strings":["Tecnologico de Monterrey. School of Engineering and Sciences,Puebla,M&#x00E9;xico"],"affiliations":[{"raw_affiliation_string":"Tecnologico de Monterrey. School of Engineering and Sciences,Puebla,M&#x00E9;xico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014251721","display_name":"Hera Andrade Zald\u00edvar","orcid":null},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Hera Andrade Zaldivar","raw_affiliation_strings":["Tecnologico de Monterrey. School of Engineering and Sciences,Puebla,M&#x00E9;xico"],"affiliations":[{"raw_affiliation_string":"Tecnologico de Monterrey. School of Engineering and Sciences,Puebla,M&#x00E9;xico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121833606","display_name":"Irma Cruz Sol\u00eds","orcid":null},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Irma Cruz Sol\u00eds","raw_affiliation_strings":["Tecnologico de Monterrey. School of Engineering and Sciences,Puebla,M&#x00E9;xico"],"affiliations":[{"raw_affiliation_string":"Tecnologico de Monterrey. School of Engineering and Sciences,Puebla,M&#x00E9;xico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019913634","display_name":"Jorge Lozano-Aponte","orcid":"https://orcid.org/0000-0003-1719-5011"},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jorge Lozano-Aponte","raw_affiliation_strings":["Tecnologico de Monterrey. School of Engineering and Sciences,Puebla,M&#x00E9;xico"],"affiliations":[{"raw_affiliation_string":"Tecnologico de Monterrey. School of Engineering and Sciences,Puebla,M&#x00E9;xico","institution_ids":["https://openalex.org/I98461037"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5091670411"],"corresponding_institution_ids":["https://openalex.org/I98461037"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66099977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13280","display_name":"Biomedical and Engineering Education","score":0.09740000218153,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11526","display_name":"Innovative Teaching Methods","score":0.07810000330209732,"subfield":{"id":"https://openalex.org/subfields/3304","display_name":"Education"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/component","display_name":"Component (thermodynamics)","score":0.5946000218391418},{"id":"https://openalex.org/keywords/perception","display_name":"Perception","score":0.4832000136375427},{"id":"https://openalex.org/keywords/experiential-learning","display_name":"Experiential learning","score":0.4542999863624573},{"id":"https://openalex.org/keywords/chatbot","display_name":"Chatbot","score":0.40689998865127563},{"id":"https://openalex.org/keywords/embodied-cognition","display_name":"Embodied cognition","score":0.3882000148296356},{"id":"https://openalex.org/keywords/bespoke","display_name":"Bespoke","score":0.3587000072002411},{"id":"https://openalex.org/keywords/self-regulated-learning","display_name":"Self-regulated learning","score":0.3531999886035919},{"id":"https://openalex.org/keywords/kinesthetic-learning","display_name":"Kinesthetic learning","score":0.3513999879360199},{"id":"https://openalex.org/keywords/curriculum","display_name":"Curriculum","score":0.3393999934196472},{"id":"https://openalex.org/keywords/perspective","display_name":"Perspective (graphical)","score":0.32339999079704285}],"concepts":[{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.5946000218391418},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4832000136375427},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.4832000136375427},{"id":"https://openalex.org/C37228920","wikidata":"https://www.wikidata.org/wiki/Q1307600","display_name":"Experiential learning","level":2,"score":0.4542999863624573},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43369999527931213},{"id":"https://openalex.org/C2779041454","wikidata":"https://www.wikidata.org/wiki/Q870780","display_name":"Chatbot","level":2,"score":0.40689998865127563},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.39410001039505005},{"id":"https://openalex.org/C100609095","wikidata":"https://www.wikidata.org/wiki/Q1335050","display_name":"Embodied cognition","level":2,"score":0.3882000148296356},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.37940001487731934},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.37279999256134033},{"id":"https://openalex.org/C44210515","wikidata":"https://www.wikidata.org/wiki/Q16968978","display_name":"Bespoke","level":2,"score":0.3587000072002411},{"id":"https://openalex.org/C2776503756","wikidata":"https://www.wikidata.org/wiki/Q1424497","display_name":"Self-regulated learning","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C55457006","wikidata":"https://www.wikidata.org/wiki/Q3647098","display_name":"Kinesthetic learning","level":2,"score":0.3513999879360199},{"id":"https://openalex.org/C47177190","wikidata":"https://www.wikidata.org/wiki/Q207137","display_name":"Curriculum","level":2,"score":0.3393999934196472},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.32339999079704285},{"id":"https://openalex.org/C2779405079","wikidata":"https://www.wikidata.org/wiki/Q356040","display_name":"Jigsaw","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C159456220","wikidata":"https://www.wikidata.org/wiki/Q667334","display_name":"Instructional design","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.3140000104904175},{"id":"https://openalex.org/C77967617","wikidata":"https://www.wikidata.org/wiki/Q4677561","display_name":"Active learning (machine learning)","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C156325361","wikidata":"https://www.wikidata.org/wiki/Q1152864","display_name":"Grounded theory","level":3,"score":0.3091000020503998},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.3086000084877014},{"id":"https://openalex.org/C16443162","wikidata":"https://www.wikidata.org/wiki/Q1068473","display_name":"Educational technology","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C2780910867","wikidata":"https://www.wikidata.org/wiki/Q1952416","display_name":"Multimodality","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C87156501","wikidata":"https://www.wikidata.org/wiki/Q7268708","display_name":"Qualitative property","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C533356498","wikidata":"https://www.wikidata.org/wiki/Q843894","display_name":"Critical thinking","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C96427005","wikidata":"https://www.wikidata.org/wiki/Q98442705","display_name":"Learning sciences","level":3,"score":0.2802000045776367},{"id":"https://openalex.org/C2776473838","wikidata":"https://www.wikidata.org/wiki/Q174165","display_name":"Innovator","level":3,"score":0.2800999879837036},{"id":"https://openalex.org/C190248442","wikidata":"https://www.wikidata.org/wiki/Q839486","display_name":"Qualitative research","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.27549999952316284},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.2750999927520752},{"id":"https://openalex.org/C2780909375","wikidata":"https://www.wikidata.org/wiki/Q1060990","display_name":"Problem-based learning","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C51672120","wikidata":"https://www.wikidata.org/wiki/Q303446","display_name":"Cooperative learning","level":3,"score":0.26190000772476196},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.2612000107765198},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.2590999901294708},{"id":"https://openalex.org/C2777765802","wikidata":"https://www.wikidata.org/wiki/Q465899","display_name":"Andragogy","level":3,"score":0.2572000026702881},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.25369998812675476},{"id":"https://openalex.org/C2781285556","wikidata":"https://www.wikidata.org/wiki/Q1820370","display_name":"Learning styles","level":2,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/enc68268.2025.11311911","is_oa":false,"landing_page_url":"https://doi.org/10.1109/enc68268.2025.11311911","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 Mexican International Conference on Computer Science (ENC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8226356506347656,"display_name":"Quality Education","id":"https://metadata.un.org/sdg/4"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2088073679","https://openalex.org/W2913208730","https://openalex.org/W2978672213","https://openalex.org/W2984028075","https://openalex.org/W4281551591","https://openalex.org/W4309700922","https://openalex.org/W4377229715","https://openalex.org/W4388013038","https://openalex.org/W4400410540","https://openalex.org/W4400411250","https://openalex.org/W4400842024","https://openalex.org/W4406210623","https://openalex.org/W4410087207","https://openalex.org/W4410947263","https://openalex.org/W4413360567","https://openalex.org/W4413360771"],"related_works":[],"abstract_inverted_index":{"We":[0,180],"present":[1],"a":[2,22,55,79,173,189],"low-cost,":[3],"UDL-grounded":[4],"instructional":[5],"approach":[6,163],"to":[7,71,101,168,183,198],"teaching":[8],"the":[9,162,200,204],"central":[10],"dogma":[11],"of":[12,203],"molecular":[13,29],"biology":[14],"in":[15,148,160],"an":[16,42],"undergraduate":[17],"course.":[18],"The":[19],"design":[20],"integrates":[21],"kinesthetic":[23],"MDF":[24],"jigsaw":[25],"with":[26,192],"PLA":[27],"3D-printed":[28],"models,":[30],"multimodal":[31,207],"accessibility":[32],"assets":[33],"(Braille":[34],"process":[35],"cards,":[36],"captioned/narrated":[37],"micro-lectures,":[38],"QR-linked":[39],"resources),":[40],"and":[41,135,153,158,166,188,195,209],"educational":[43],"chatbot":[44],"that":[45],"delivers":[46],"formative,":[47],"rationale-seeking":[48],"feedback":[49],"on":[50,78,155],"student-generated":[51],"case":[52],"studies.":[53],"In":[54],"pilot":[56],"cohort":[57],"(<tex":[58],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[59,63,73,83,88,94,113,117,126,133,138,145],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$N=18$</tex>;":[60],"matched":[61],"<tex":[62,72,82,87,93,112,116,125,132,137,144],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$n=10$</tex>),":[64],"learning":[65],"scores":[66],"increased":[67],"from":[68,99],"8.2":[69],"(pre)":[70],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$9.6":[74],"/":[75,128,140],"10$</tex>":[76],"(post)":[77],"paired":[80],"test,":[81],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathrm{t}(9)=2.91$</tex>,":[84],"two-tailed":[85],"p":[86],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$=0.017,95":[89],"\\%":[90],"\\text{CI}$</tex>":[91],"for":[92,151,176],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\Delta":[95],"\\mathrm{M}=1.4:[0.31,2.49]$</tex>;":[96],"variance":[97],"decreased":[98],"3.07":[100],"0.27,":[102],"indicating":[103],"greater":[104],"response":[105],"consistency.":[106],"Standardized":[107],"effects":[108],"were":[109],"large":[110],"(paired":[111],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathbf{d}_{(\\mathbf{z})}=0.92$</tex>;":[114],"Hedges'":[115],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathbf{g}":[118],"\\approx$</tex>":[119],"0.98).":[120],"Perception":[121],"data":[122],"showed":[123],"impact/usefulness":[124],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$=69.7":[127],"100$</tex>":[129,141],"(collaborative":[130],"work":[131],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$=94$</tex>)":[134],"engagement":[136],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$=75.5":[139],"(self-regulation/strategic":[142],"thinking":[143],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$=89$</tex>).":[146],"Grounded":[147],"Universal":[149],"Design":[150],"Learning":[152],"research":[154],"serious":[156],"games":[157],"chatbots":[159],"education,":[161],"is":[164],"scalable":[165],"transferable":[167,174],"related":[169],"life-science":[170],"topics,":[171],"providing":[172],"framework":[175],"inclusive":[177],"STEM":[178],"education.":[179],"outline":[181],"threats":[182],"validity":[184],"(sample":[185],"size,":[186],"instrumentation)":[187],"replication":[190],"plan":[191],"pre-registered":[193],"analyses":[194],"component":[196],"ablation":[197],"benchmark":[199],"relative":[201],"contribution":[202],"tactile":[205],"kit,":[206],"media,":[208],"chatbot.":[210]},"counts_by_year":[],"updated_date":"2026-01-03T23:08:47.215875","created_date":"2026-01-02T00:00:00"}