{"id":"https://openalex.org/W4405488627","doi":"https://doi.org/10.1109/embc53108.2024.10782975","title":"Electric Field Modeling for Planning Individualized HD-tACS to Target DLPFC in the Aging Brain","display_name":"Electric Field Modeling for Planning Individualized HD-tACS to Target DLPFC in the Aging Brain","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405488627","doi":"https://doi.org/10.1109/embc53108.2024.10782975","pmid":"https://pubmed.ncbi.nlm.nih.gov/40038944"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10782975","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782975","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102732296","display_name":"Diego E. Arias","orcid":"https://orcid.org/0000-0002-2180-1494"},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diego E. Arias","raw_affiliation_strings":["Medical University of South Carolina,Department of Health Sciences and Research,Charleston,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina,Department of Health Sciences and Research,Charleston,USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070882571","display_name":"Kirstin-Friederike Heise","orcid":"https://orcid.org/0000-0003-3666-8531"},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirstin-Friederike Heise","raw_affiliation_strings":["Medical University of South Carolina,Department of Health Sciences and Research,Charleston,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina,Department of Health Sciences and Research,Charleston,USA","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":null,"apc_paid":null,"fwci":0.3505,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60557531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10660","display_name":"Conducting polymers and applications","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.5543481707572937},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5351285338401794},{"id":"https://openalex.org/keywords/brain-cell","display_name":"Brain Cell","score":0.4247966706752777},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.40481531620025635},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1989096999168396}],"concepts":[{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.5543481707572937},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5351285338401794},{"id":"https://openalex.org/C2778144876","wikidata":"https://www.wikidata.org/wiki/Q4955745","display_name":"Brain Cell","level":2,"score":0.4247966706752777},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40481531620025635},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1989096999168396},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000087643","descriptor_name":"Dorsolateral Prefrontal Cortex","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000087643","descriptor_name":"Dorsolateral Prefrontal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000087643","descriptor_name":"Dorsolateral Prefrontal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000087643","descriptor_name":"Dorsolateral Prefrontal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000087643","descriptor_name":"Dorsolateral Prefrontal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000087643","descriptor_name":"Dorsolateral Prefrontal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010719","descriptor_name":"Phosphenes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010719","descriptor_name":"Phosphenes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010719","descriptor_name":"Phosphenes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065908","descriptor_name":"Transcranial Direct Current Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065908","descriptor_name":"Transcranial Direct Current Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065908","descriptor_name":"Transcranial Direct Current Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065908","descriptor_name":"Transcranial Direct Current Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D065908","descriptor_name":"Transcranial Direct Current Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10782975","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782975","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40038944","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40038944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8047581669","display_name":null,"funder_award_id":"UL1 TR001450","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"}],"funders":[{"id":"https://openalex.org/F4320309383","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2043955468","https://openalex.org/W2075175894","https://openalex.org/W2079748473","https://openalex.org/W2151721316","https://openalex.org/W2339423396","https://openalex.org/W2499800833","https://openalex.org/W2563299902","https://openalex.org/W2904945319","https://openalex.org/W2912676447","https://openalex.org/W2927777239","https://openalex.org/W2991555451","https://openalex.org/W3004493719","https://openalex.org/W3034190502","https://openalex.org/W3110852561","https://openalex.org/W4206207660"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Tuning":[0],"brain":[1,5,14],"activity":[2],"with":[3,21,90],"non-invasive":[4],"stimulation":[6],"critically":[7],"depends":[8],"on":[9],"optimized":[10],"targeting":[11,40],"of":[12,16,67,104,147,153,179,207,218],"the":[13,35,41,64,111,120,129,134,145,151,154,158,177,180,186,205,208,212,216],"structures":[15],"interest,":[17],"especially":[18],"in":[19,30,54,88,140,150,166],"populations":[20],"accelerated":[22],"interindividual":[23],"morphological":[24],"variations":[25],"as":[26],"they":[27],"are":[28],"typical":[29],"aging.":[31],"Here,":[32],"we":[33],"explored":[34],"electric":[36,65,113,117,155,199,209],"field":[37,66,114,118,141,156,200,210],"distribution":[38],"when":[39,127],"right":[42],"dorsolateral":[43],"prefrontal":[44],"cortex":[45],"(DLPFC)":[46],"using":[47,86,128],"High-Definition":[48],"Transcranial":[49],"Alternating":[50],"Current":[51],"Stimulation":[52],"(HD-tACS)":[53],"both":[55],"young":[56],"(YA)":[57],"and":[58,97,115],"older":[59],"adults":[60],"(OA).":[61],"We":[62,92],"modeled":[63],"ten":[68],"datasets":[69],"(OA:":[70],"n=5,":[71,77],"63-76":[72],"y/o,":[73,79],"68.4\u00b16.5":[74],"y/o;":[75],"YA:":[76],"18-39":[78],"27.4\u00b17.5":[80],"y/o)":[81],"comprising":[82],"T1-and":[83],"T2-weighted":[84],"images":[85],"SimNIBS":[87],"combination":[89],"FreeSurfer.":[91],"simulated":[93],"two":[94],"montages":[95],"(2x1":[96],"4x1)":[98],"to":[99,133,175,184,195],"deliver":[100],"a":[101,172,197],"net":[102],"current":[103],"2":[105],"mA.":[106],"The":[107],"simulations":[108,189],"revealed":[109],"that":[110,191],"peak":[112,162],"mean":[116],"at":[119,144],"DLPFC":[121],"were":[122,164],"approximately":[123],"three":[124],"times":[125],"stronger":[126],"2x1":[130,181],"montage":[131,182],"compared":[132],"4x1":[135],"montage.":[136],"However,":[137],"this":[138],"increase":[139],"strength":[142],"came":[143],"expense":[146],"focality,":[148],"resulting":[149],"spread":[152,206],"into":[157,211],"ocular":[159],"area,":[160],"where":[161],"values":[163],"observed":[165],"some":[167],"participants.":[168],"In":[169],"these":[170],"cases,":[171],"viable":[173],"approach":[174],"enhance":[176],"efficacy":[178],"was":[183],"individualize":[185],"current.":[187],"Our":[188],"showed":[190],"it":[192],"is":[193],"possible":[194],"generate":[196],"similar":[198],"among":[201],"participants":[202],"while":[203],"mitigating":[204],"eye,":[213],"thereby":[214],"reducing":[215],"likelihood":[217],"phosphenes.":[219]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-07-03T08:13:44.112507","created_date":"2025-10-10T00:00:00"}
