{"id":"https://openalex.org/W4405489002","doi":"https://doi.org/10.1109/embc53108.2024.10782828","title":"Microcavity based Biosensor for Detection of SARS-CoV-2","display_name":"Microcavity based Biosensor for Detection of SARS-CoV-2","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405489002","doi":"https://doi.org/10.1109/embc53108.2024.10782828","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039275"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10782828","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782828","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004835193","display_name":"Yi Su","orcid":"https://orcid.org/0000-0002-1946-8063"},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Su","raw_affiliation_strings":["Westlake University,CenBRAIN Neurotech, School of Engineering,Hangzhou,China,310030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University,CenBRAIN Neurotech, School of Engineering,Hangzhou,China,310030","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101571224","display_name":"Zhen Cui","orcid":"https://orcid.org/0000-0002-8292-6389"},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Cui","raw_affiliation_strings":["Westlake University,Key Laboratory for Quantum Materials of Zhejiang Province, School of Science,Hangzhou,China,310030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University,Key Laboratory for Quantum Materials of Zhejiang Province, School of Science,Hangzhou,China,310030","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029815486","display_name":"P. G. Savvidis","orcid":"https://orcid.org/0000-0002-8186-6679"},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pavlos Savvidis","raw_affiliation_strings":["Westlake University,Key Laboratory for Quantum Materials of Zhejiang Province, School of Science,Hangzhou,China,310030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University,Key Laboratory for Quantum Materials of Zhejiang Province, School of Science,Hangzhou,China,310030","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052176076","display_name":"Guoguang Rong","orcid":null},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoguang Rong","raw_affiliation_strings":["Westlake University,CenBRAIN Neurotech, School of Engineering,Hangzhou,China,310030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University,CenBRAIN Neurotech, School of Engineering,Hangzhou,China,310030","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082509767","display_name":"Mohamad Sawan","orcid":"https://orcid.org/0000-0002-4137-7272"},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mohamad Sawan","raw_affiliation_strings":["Westlake University,CenBRAIN Neurotech, School of Engineering,Hangzhou,China,310030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westlake University,CenBRAIN Neurotech, School of Engineering,Hangzhou,China,310030","institution_ids":["https://openalex.org/I3133055985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3133055985"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20148693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11272","display_name":"Nanowire Synthesis and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11272","display_name":"Nanowire Synthesis and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11449","display_name":"Mechanical and Optical Resonators","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.6850875616073608},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45621955394744873},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.4390799403190613},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.3380325436592102},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.32747653126716614},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.1719752550125122},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.16836872696876526},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1633215844631195},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08482834696769714}],"concepts":[{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.6850875616073608},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45621955394744873},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.4390799403190613},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.3380325436592102},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.32747653126716614},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1719752550125122},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.16836872696876526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1633215844631195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08482834696769714},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019095","descriptor_name":"Point-of-Care Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc53108.2024.10782828","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782828","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039275","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:publications.polymtl.ca:74212","is_oa":false,"landing_page_url":"https://publications.polymtl.ca/74212/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401013","display_name":"PolyPublie (\u00c9cole Polytechnique de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45683168","host_organization_name":"Polytechnique Montr\u00e9al","host_organization_lineage":["https://openalex.org/I45683168"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318567","display_name":"Westlake University","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2134434620","https://openalex.org/W2965832921","https://openalex.org/W3008856502","https://openalex.org/W3029978176","https://openalex.org/W3185738448","https://openalex.org/W3195044398","https://openalex.org/W3207530931","https://openalex.org/W3209929942","https://openalex.org/W4377291244","https://openalex.org/W4386286162","https://openalex.org/W6778646867"],"related_works":["https://openalex.org/W4206669628","https://openalex.org/W4205317059","https://openalex.org/W4224279380","https://openalex.org/W3176864053","https://openalex.org/W4206651655","https://openalex.org/W4292098121","https://openalex.org/W4210433452","https://openalex.org/W3036314732","https://openalex.org/W3084808338","https://openalex.org/W3196306939"],"abstract_inverted_index":{"During":[0],"a":[1,53,56,81,90],"pandemic,":[2],"infectious":[3],"diseases":[4],"can":[5,59],"lead":[6],"to":[7,45,66,103,109,122],"significant":[8],"health":[9],"and":[10,37,73],"societal":[11],"challenges.":[12],"While":[13],"advanced":[14],"technologies":[15],"have":[16,27],"been":[17],"developed":[18],"for":[19,55,93,150,160],"the":[20,70,95,116,123,128,139,152,155],"accurate":[21],"detection":[22,31,124,131],"of":[23,106,125,130],"SARS-CoV-2,":[24],"they":[25],"still":[26],"limitations.":[28],"The":[29],"entire":[30],"process,":[32],"including":[33],"sampling,":[34],"pre-treatment,":[35],"analysis,":[36],"data":[38],"reporting,":[39],"often":[40],"takes":[41],"several":[42],"hours,":[43],"leading":[44,108],"delays":[46],"in":[47],"treatment":[48],"decisions.":[49],"Therefore,":[50,154],"there":[51],"is":[52],"need":[54],"technique":[57,92],"that":[58,83],"provide":[60],"rapid":[61],"results,":[62],"preferably":[63],"accessible":[64],"directly":[65],"individuals,":[67],"benefiting":[68],"both":[69],"general":[71],"public":[72],"healthcare":[74],"systems.":[75],"In":[76,137],"this":[77],"study,":[78],"we":[79],"introduce":[80],"biosensor":[82,111,118,156],"utilizes":[84],"microcavity-based":[85,117],"dark-field":[86],"reflectivity,":[87],"thus":[88],"providing":[89],"powerful":[91],"sensing":[94],"covering":[96],"virus":[97],"layer.":[98],"Moreover,":[99],"aptamers":[100],"are":[101],"used":[102],"specific":[104],"bonding":[105],"viruses,":[107],"improved":[110],"accuracy.":[112],"Data":[113],"obtained":[114],"from":[115],"show":[119],"high":[120],"sensitivity":[121],"pseudo-viruses,":[126],"with":[127],"limit":[129],"at":[132],"10<sup":[133,146],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[134,147],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sup>":[135],"copies.":[136],"comparison,":[138],"polymerase":[140],"chain":[141],"reaction":[142],"requires":[143],"more":[144],"than":[145],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">3</sup>":[148],"copies":[149],"monitoring":[151],"viruses.":[153],"shows":[157],"considerable":[158],"potential":[159],"point-of-care":[161],"testing.":[162]},"counts_by_year":[],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}