{"id":"https://openalex.org/W4405490241","doi":"https://doi.org/10.1109/embc53108.2024.10782731","title":"3D-Printed Scaffold Mimicking IBD Gut Microenvironments: An In Vitro Model for Bacterial Bioink Growth","display_name":"3D-Printed Scaffold Mimicking IBD Gut Microenvironments: An In Vitro Model for Bacterial Bioink Growth","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405490241","doi":"https://doi.org/10.1109/embc53108.2024.10782731","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039600"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10782731","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782731","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100668758","display_name":"Alejandro Garc\u00eda","orcid":"https://orcid.org/0000-0002-7250-4641"},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Alejandro Garc\u00eda-Gonz\u00e1lez","raw_affiliation_strings":["School of Medicine and Health Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Health Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115513607","display_name":"Mariana J\u00e1quez-S\u00e1nchez","orcid":null},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mariana J\u00e1quez-S\u00e1nchez","raw_affiliation_strings":["School of Medicine and Health Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Health Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115513608","display_name":"Axel Maya-Morales","orcid":null},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Axel Maya-Morales","raw_affiliation_strings":["School of Medicine and Health Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Health Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060492914","display_name":"Mariana S. Flores-Jim\u00e9nez","orcid":"https://orcid.org/0000-0002-1392-7660"},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mariana S. Flores-Jim\u00e9nez","raw_affiliation_strings":["School of Engineering and Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering and Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091843872","display_name":"Yocanx\u00f3chitl Perfecto\u2010Avalos","orcid":"https://orcid.org/0000-0002-8503-1310"},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Yocanx\u00f3chitl Perfecto-Avalos","raw_affiliation_strings":["School of Engineering and Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering and Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079939647","display_name":"Isaac Cha\u00edrez","orcid":"https://orcid.org/0000-0002-7157-2052"},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Isaac Chairez-Oria","raw_affiliation_strings":["Tecnologico de Monterrey,Institute of Advanced Materials for Sustainable Manufacturing,Zapopan,Jalisco,Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tecnologico de Monterrey,Institute of Advanced Materials for Sustainable Manufacturing,Zapopan,Jalisco,Mexico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093468268","display_name":"Abel Guti\u00e9rrez-Vilchis","orcid":null},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Abel Gutierrez-Vilchis","raw_affiliation_strings":["School of Medicine and Health Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Health Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021789399","display_name":"Ricardo Garc\u00eda\u2010Gamboa","orcid":"https://orcid.org/0000-0002-7226-3315"},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ricardo Garc\u00eda-Gamboa","raw_affiliation_strings":["School of Medicine and Health Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Health Sciences,Tecnologico de Monterrey,Zapopan,Jalisco,Mexico","institution_ids":["https://openalex.org/I98461037"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100668758"],"corresponding_institution_ids":["https://openalex.org/I98461037"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21153885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9354000091552734,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scaffold","display_name":"Scaffold","score":0.7459011673927307},{"id":"https://openalex.org/keywords/3d-printed","display_name":"3d printed","score":0.7320444583892822},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.5360499024391174},{"id":"https://openalex.org/keywords/bacterial-growth","display_name":"Bacterial growth","score":0.5296796560287476},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3927463889122009},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.2661629915237427},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.24882158637046814},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23285964131355286},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.2026764154434204},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.16245362162590027},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06410422921180725},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.05557963252067566}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.7459011673927307},{"id":"https://openalex.org/C3019308078","wikidata":"https://www.wikidata.org/wiki/Q229367","display_name":"3d printed","level":2,"score":0.7320444583892822},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5360499024391174},{"id":"https://openalex.org/C17741926","wikidata":"https://www.wikidata.org/wiki/Q762045","display_name":"Bacterial growth","level":3,"score":0.5296796560287476},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3927463889122009},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2661629915237427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24882158637046814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23285964131355286},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2026764154434204},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16245362162590027},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06410422921180725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05557963252067566}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007281","descriptor_name":"Ink","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007281","descriptor_name":"Ink","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013294","descriptor_name":"Lactococcus lactis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013294","descriptor_name":"Lactococcus lactis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013294","descriptor_name":"Lactococcus lactis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D062028","descriptor_name":"Bioprinting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D062028","descriptor_name":"Bioprinting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D062028","descriptor_name":"Bioprinting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10782731","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782731","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039600","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.800000011920929,"display_name":"Zero hunger"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W2137334161","https://openalex.org/W2591030845","https://openalex.org/W2773156981","https://openalex.org/W2964863261","https://openalex.org/W2965690386","https://openalex.org/W3151176174","https://openalex.org/W4283013573","https://openalex.org/W4288905753","https://openalex.org/W4309694165","https://openalex.org/W4310371251","https://openalex.org/W4311521684","https://openalex.org/W4381052331","https://openalex.org/W4381619070","https://openalex.org/W6680149484"],"related_works":["https://openalex.org/W2081717811","https://openalex.org/W2695162732","https://openalex.org/W2884765235","https://openalex.org/W2351880312","https://openalex.org/W3136373005","https://openalex.org/W2349140385","https://openalex.org/W2092217920","https://openalex.org/W1991154725","https://openalex.org/W2774256619","https://openalex.org/W4390094986"],"abstract_inverted_index":{"Inflammatory":[0],"bowel":[1],"disease":[2],"(IBD),":[3],"a":[4,28,94,105,119,138],"chronic":[5],"inflammatory":[6],"condition":[7],"of":[8,27,51,80,87,114,133],"the":[9,25,90,108,112,131,143,146],"gastrointestinal":[10],"tract,":[11],"affects":[12],"millions":[13],"worldwide":[14],"and":[15,45,100],"is":[16],"linked":[17],"to":[18,104,141],"altered":[19],"gut":[20],"microbiota.":[21],"This":[22,92],"study":[23,129],"explored":[24],"feasibility":[26],"3D-bioprinting":[29],"scaffold":[30,110],"containing":[31],"Lactococcus":[32],"lactis":[33,68,125],"using":[34],"an":[35],"alginate-agar-soy":[36],"trypticase":[37],"bioink.":[38],"The":[39,56],"bioink":[40],"exhibited":[41],"high":[42],"water":[43],"absorption":[44],"adequate":[46],"rheology,":[47],"enabling":[48],"successful":[49],"bioprinting":[50],"scaffolds":[52,57,136],"with":[53],"robust":[54],"structures.":[55],"remained":[58],"stable":[59],"for":[60,97,123],"24":[61],"hours,":[62],"allowing":[63],"prolonged":[64],"bacterial":[65,98,135],"growth.":[66,126],"L.":[67,124],"viability":[69],"was":[70],"confirmed":[71],"by":[72],"confocal":[73],"microscopy,":[74],"which":[75],"revealed":[76],"green":[77],"fluorescence":[78],"indicative":[79],"live":[81],"bacteria":[82],"even":[83],"after":[84],"8":[85],"hours":[86],"culture":[88,140],"within":[89],"scaffold.":[91],"suggests":[93],"supportive":[95,121],"microenvironment":[96],"survival":[99],"potential":[101,132],"proliferation.":[102],"Compared":[103],"2D":[106],"model,":[107],"3D":[109],"increased":[111],"number":[113],"colony-forming":[115],"units":[116],"(CFUs),":[117],"indicating":[118],"more":[120],"environment":[122],"Overall,":[127],"this":[128],"emphasizes":[130],"3D-printed":[134],"as":[137],"platform":[139],"assess":[142],"factors":[144],"influencing":[145],"microbiota":[147],"in":[148],"various":[149],"diseases.":[150]},"counts_by_year":[],"updated_date":"2026-04-25T08:17:42.794288","created_date":"2025-10-10T00:00:00"}